公开(公告)号：US20080125429A1

公开(公告)日：2008-05-29

申请号：US11666555

申请日：2005-11-01

申请人： Noriaki Hashimoto ,  Keiji Takahashi ,  Chisato Nakama ,  Yoshio Ogino ,  Fumiko Sakai ,  Teruyuki Nishimura ,  Jun-ichi Eiki

发明人： Noriaki Hashimoto ,  Keiji Takahashi ,  Chisato Nakama ,  Yoshio Ogino ,  Fumiko Sakai ,  Teruyuki Nishimura ,  Jun-ichi Eiki

IPC分类号： A61K31/5377 ,  C07D213/02 ,  C07D221/00 ,  C07D239/06 ,  C07D241/10 ,  C07D295/00 ,  A61P3/10 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/506 ,  A61K31/497

CPC分类号： A61K38/31 ,  A61K31/155 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K38/28 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/06 ,  C07D413/14 ,  A61K2300/00

摘要： A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

摘要翻译： 提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防，或治疗和/或预防糖尿病如视网膜病，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的治疗和/或预防肥胖症。 本发明涉及式（I）的化合物：其中R 1和R 2代表氢等; R 3表示氢原子，卤素原子等; R 4各自独立地表示氢原子，低级烷基等; Q表示碳原子，氮原子或硫原子（硫原子可以被氧代基单取代或二取代）。 R 5和R 6各自表示氢原子，低级烷基等; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; Z表示氧原子，硫原子或氮原子; Ar表示任选被选自取代基组β的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数， n表示0〜3的整数， p表示0〜2的整数（条件是X 1〜X 4中的至少2个为碳原子）; q表示0或1]或其药学上可接受的盐，其具有葡糖激酶活化的作用，并且可用作糖尿病的治疗。

公开(公告)号：US07333096B2

公开(公告)日：2008-02-19

申请号：US10316193

申请日：2002-12-11

申请人： Hajime Washio ,  Yasuyoshi Kaise ,  Sachio Tsujino ,  Kazuhiro Maeda ,  Keiji Takahashi ,  Yasushi Kubota ,  Toshiya Aoki

发明人： Hajime Washio ,  Yasuyoshi Kaise ,  Sachio Tsujino ,  Kazuhiro Maeda ,  Keiji Takahashi ,  Yasushi Kubota ,  Toshiya Aoki

IPC分类号： G09G5/00 ,  G09G3/36

CPC分类号： G09G3/3688 ,  G09G3/3614 ,  G09G3/3648 ,  G09G3/3666 ,  G09G3/3677 ,  G09G2310/0213 ,  G09G2310/0232 ,  G09G2310/027 ,  G09G2310/0283 ,  G09G2310/0297 ,  G09G2310/04 ,  G09G2320/0214 ,  G09G2320/10 ,  G09G2330/021

摘要： A control signal generating circuit CTL for controlling the writing into pixels PIX instructs a data signal line drive circuit SD2, which is for driving pixels in a non-display area, to write a voltage VB or a voltage VW which are for non-displaying, not only in the first frame but also once in a predetermined number of frames. In other words, the pixels in the display area is refreshed at intervals longer than those in the case of refreshing the pixels in each frame. Thus, even if the mobility of an active element is high and the leak current on the occasion of OFF-state is large, or even if a large amount of electric charge is accumulated because of the photoelectric effect due to the use of a backlight, it is possible to prevent unnecessary displaying on the display area, which is caused because the writing into the pixels in the display area influences on the pixels in the non-display area, and hence it is possible to improve the quality of partial displaying, while restraining the power consumption.

摘要翻译： 用于控制向像素PIX写入的控制信号发生电路CTL指示用于驱动非显示区域中的像素的数据信号线驱动电路SD 2写入用于不显示的电压VB或电压VW ，不仅在第一帧中，而且在预定数量的帧中也是一次。 换句话说，显示区域中的像素以比刷新每帧中的像素的情况更长的间隔更新。 因此，即使有源元件的迁移率高，关断状态下的漏电流大，或者即使由于使用背光导致的光电效应而累积大量的电荷， 可以防止由于对显示区域中的像素的写入而影响非显示区域中的像素而导致的显示区域的不必要的显示，因此可以提高部分显示的质量，同时 限制功耗。

公开(公告)号：US20070221182A1

公开(公告)日：2007-09-27

申请号：US11728039

申请日：2007-03-23

申请人： Keiji Takahashi ,  Atsufumi Ozaki

发明人： Keiji Takahashi ,  Atsufumi Ozaki

IPC分类号： F02P3/02 ,  F01M9/10 ,  F02M35/02

CPC分类号： F02P13/00 ,  F02M35/02 ,  F02M35/112 ,  F02M35/167

摘要： An engine equipped with an air-intake device for a personal watercraft, includes a cylinder head cover attached to an upper surface of a cylinder head, a plug cap with ignition coil configured to protrude upward from an upper surface of the cylinder head cover; and an air box for the air-intake device that is disposed above the cylinder head cover and is provided on a lower surface thereof with an air inlet that opens to be opposite to the upper surface of the cylinder head cover. The air box is disposed in such a manner that the lower surface of the air box is opposite to the upper surface of the cylinder head cover and a gap is formed between the lower surface of the air box and the upper surface of the cylinder head cover so as to form an air flow in the vicinity of the plug cap with ignition coil that is directed to the air inlet of the air box.

摘要翻译： 配备有用于个人船舶的进气装置的发动机包括附接到气缸盖的上表面的气缸盖罩，具有点火线圈的插头盖，其配置成从气缸盖罩的上表面向上突出; 以及用于进气装置的空气箱，其设置在气缸盖罩的上方，并且在其下表面上设置有与气缸盖罩的上表面相对开口的空气入口。 风箱以这样的方式设置，使得气箱的下表面与气缸盖罩的上表面相对，并且在气箱的下表面和气缸盖罩的上表面之间形成间隙 以便在引导到空气箱的空气入口的点火线圈在塞帽附近形成空气流。

公开(公告)号：US07052343B2

公开(公告)日：2006-05-30

申请号：US11026170

申请日：2004-12-29

申请人： Atsufumi Ozaki ,  Keiji Takahashi

发明人： Atsufumi Ozaki ,  Keiji Takahashi

IPC分类号： B63H21/38

CPC分类号： B63H21/32 ,  B63B35/731 ,  B63H21/14 ,  B63H21/24

摘要： A personal watercraft is disclosed. The personal watercraft typically includes a body formed by a hull and a deck covering the hull from above and having an inner space defined by the hull and the deck, an engine accommodated in the inner space of the body, and an exhaust pipe accommodated in the inner space and configured to guide an exhaust gas emitted from the engine outside the body. The body is typically provided with a penetrating hole through which an inside of the body and an outside of the body communicate with each other. The exhaust pipe is typically configured to extend through the penetrating hole and mounted to the body by a mounting device in the vicinity of the penetrating hole, and the mounting device is removably mounted to the body from outside the body.

摘要翻译： 披露了一艘私人船只。 私人船舶通常包括由船体和甲板形成的船体，甲板从上方覆盖船体，并具有由船体和甲板限定的内部空间，容纳在船体内部空间中的发动机和容纳在船体内的排气管 内部空间并且构造成引导从发动机在体外排出的废气。 身体通常设置有穿透孔，身体的内部和身体的外部通过该通孔彼此连通。 排气管通常被配置为延伸穿过该穿孔并通过安装装置安装在本体附近，并且该安装装置从身体外部可拆卸地安装到主体上。

公开(公告)号：US06769763B2

公开(公告)日：2004-08-03

申请号：US09947477

申请日：2001-09-07

申请人： Tetsuji Kurata ,  Hirofumi Hirano ,  Yoshitaka Okamura ,  Keiji Takahashi

发明人： Tetsuji Kurata ,  Hirofumi Hirano ,  Yoshitaka Okamura ,  Keiji Takahashi

IPC分类号： B41J2175

CPC分类号： B41J3/445 ,  B41J2/16523 ,  B41J2/17509 ,  B41J2/17596 ,  B41J2002/1728

摘要： Down-sizing of a pump for sucking two types of different fluids is realized. The pump is provided with a cylinder pump having a cylinder main body having a reciprocally movable piston, a first cylinder chamber partitioned at one side of the piston for being introduced with a first fluid, and a second cylinder chamber partitioned at the other side of the piston for being introduced with a second fluid, and piston driving means for reciprocally moving the piston of the cylinder pump.

摘要翻译： 实现了用于吸入两种不同流体的泵的缩小。 该泵设置有具有圆筒主体的气缸泵，该气缸主体具有可往复运动的活塞，在活塞一侧分隔的第一气缸室，用于引入第一流体;以及第二气缸室， 用于引入第二流体的活塞以及用于使气缸泵的活塞往复运动的活塞驱动装置。

公开(公告)号：US5552116A

公开(公告)日：1996-09-03

申请号：US423322

申请日：1995-04-17

申请人： Hiroshi Yokota ,  Keiji Takahashi

发明人： Hiroshi Yokota ,  Keiji Takahashi

IPC分类号： G01N35/04 ,  G01N35/00

CPC分类号： G01N35/00029 ,  G01N2035/00059 ,  G01N2035/00108 ,  Y10T436/11 ,  Y10T436/112499

摘要： A test strip pick-up mechanism in an automated analyzer, which comprises: a bottle holder removably holding a test strip bottle containing a plurality of test strips and having a pierced groove formed in the peripheral direction and a test strip pick-up portion connected to the groove and formed in the longitudinal direction; a bottle turning motor connected to the bottle holder; a guide member extended from the inner part of the bottle holder in parallel to the central axis of the test strip bottle and having a L-shaped guide portion formed over the entire length of the guide member with suction holes for adsorbing the test strips being formed on the guide portion which is adjacent to the test strip pick-up portion; claws engaged with the groove of the bottle holder; an air chuck having suction holes for drawing out the test strips contained in the test strip bottle; a movable member on which the air chuck is mounted; a test strip drawing out motor connected to the movable member via a guide bar; depressing arms for pushing the air chuck downward; and an air chuck depressing motor connected to the depressing arms via a shaft.

摘要翻译： 一种自动分析装置中的测试条拾取机构，包括：可拆卸地保持包含多个测试条的测试条瓶并具有沿圆周方向形成的穿孔的瓶保持架，以及连接到 所述槽沿长度方向形成; 瓶旋转马达连接到瓶架; 引导构件从保持器的内部平行于测试条瓶的中心轴线延伸，并且具有在引导构件的整个长度上形成的L形引导部分，其具有用于吸附形成的测试条的抽吸孔 在与测试条拾取部分相邻的引导部分上; 与瓶架凹槽接合的爪; 空气卡盘，其具有用于拉出包含在测试条瓶中的测试条的抽吸孔; 安装有空气卡盘的可动部件; 通过引导杆拉出连接到可动件的马达的测试条; 按压臂向下推动空气卡盘; 以及通过轴连接到所述按压臂的空气卡盘压下马达。

公开(公告)号：US5540887A

公开(公告)日：1996-07-30

申请号：US422259

申请日：1995-04-14

申请人： Hiroshi Yokota ,  Keiji Takahashi

发明人： Hiroshi Yokota ,  Keiji Takahashi

IPC分类号： G01N35/04 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00059 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499 ,  Y10T436/114165

摘要： A test strip overturning mechanism in an automated analyzer for arranging test strips such that the right sides thereof may face in one direction, which comprises: an overturning device having an arm portion with suction holes being formed thereon; and a motor connected to the overturning device via a rotary shaft, wherein the suction holes formed on the arm portion are aligned in a straight line with suction holes formed on a transportation stage, arranged in the direction orthogonal to the direction that the test strips are moved; and a turntable is disposed at the position corresponding to the location of the arm portion when the overturning device is turned 180.degree. around the rotary shaft.

摘要翻译： 一种自动分析仪中的测试条翻转机构，用于布置测试条，使得其右侧可以在一个方向上面对，其包括：翻转装置，具有在其上形成有抽吸孔的臂部; 以及通过旋转轴连接到翻转装置的电动机，其中形成在所述臂部上的所述吸入孔沿着与所述测试条的方向正交的方向与形成在输送台上的吸入孔直线对准 移动 并且当翻转装置围绕旋转轴转动180°时，转台设置在与臂部的位置相对应的位置处。

公开(公告)号：US08507505B2

公开(公告)日：2013-08-13

申请号：US13133673

申请日：2009-12-09

申请人： Makoto Bamba ,  Hidetomo Furuyama ,  Toshihiro Sakamoto ,  Satoshi Sunami ,  Keiji Takahashi ,  Fuyuki Yamamoto ,  Takashi Yoshizumi

发明人： Makoto Bamba ,  Hidetomo Furuyama ,  Toshihiro Sakamoto ,  Satoshi Sunami ,  Keiji Takahashi ,  Fuyuki Yamamoto ,  Takashi Yoshizumi

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/519 ,  A61K31/5377 ,  C07D487/04 ,  C07D519/00

摘要： The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Ar1 is an optionally substituted aryl or heteroaryl group; R1 is a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; R2 is an optionally substituted aryl, aralkyl, or heteroaryl group; and R3 is a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy.

摘要翻译： 本发明涉及以下通式（I）的化合物等。 在式中，Ar 1是任选取代的芳基或杂芳基; R 1是氢原子，任选取代的C 1 -C 6烷基，或任选取代的芳基，芳烷基或杂芳基; R2是任选取代的芳基，芳烷基或杂芳基; 并且R 3是氢原子或C 1 -C 6烷基。 本发明的化合物具有优异的Wee1激酶抑制作用，因此可用于医药领域，特别是在各种类型的癌症治疗中。

公开(公告)号：US20130030080A1

公开(公告)日：2013-01-31

申请号：US13218779

申请日：2011-08-26

申请人： Yusei Kadobayashi ,  Masako Shigesawa ,  Keiji Takahashi

发明人： Yusei Kadobayashi ,  Masako Shigesawa ,  Keiji Takahashi

IPC分类号： A61K6/083

CPC分类号： A61K6/06 ,  A61K6/0005 ,  A61K6/0008 ,  A61K6/0058 ,  A61K6/0094 ,  A61K6/083 ,  C08L33/08 ,  C08L33/10

摘要： There is provided a dental composition comprising at least one kind of filler and resin matrix, wherein the at least one kind of filler comprises a population of particles, wherein the population of particles has an average particle size from 110 to 500 μm, the maximum particle size of the population of particles is less than 1.4 times the average particle size, and the D30 of particle size distribution of the population of particles is no less than 0.9 times the average particle size.

摘要翻译： 提供了包含至少一种填料和树脂基质的牙科用组合物，其中所述至少一种填料包含一群颗粒，其中所述颗粒群平均粒径为110-500μm，最大颗粒 颗粒群的尺寸小于平均粒径的1.4倍，颗粒群粒径分布的D30不小于平均粒径的0.9倍。

公开(公告)号：US08288396B2

公开(公告)日：2012-10-16

申请号：US13202773

申请日：2010-02-18

申请人： Yasuhiro Goto ,  Kenji Niiyama ,  Satoshi Sunami ,  Keiji Takahashi

发明人： Yasuhiro Goto ,  Kenji Niiyama ,  Satoshi Sunami ,  Keiji Takahashi

IPC分类号： A61K31/519 ,  C07D487/14

CPC分类号： C07D487/14 ,  C07D519/00

摘要： The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a): R1 means a —(C═O)aOb(C1-C6)alkyl group, a —(C═O)aOb(C2-C6)alkenyl group, a —(C═O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a —(C═O)aOb(C1-C6)alkyl group or a group of —(C═O)aN(R1e)R2e; R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.

摘要翻译： 本发明提供一种用于癌症化疗或放射治疗的新型抗癌剂或敏化剂。 通式（I）的化合物：其中A表示芳基或杂芳基，或式（a）的基团：R 1表示 - （C = O）a O b（C 1 -C 6）烷基， - （C = O）a O b（C 2 -C 6）烯基， - （C = O）a O b（C 3 -C 6）环烷基，芳基或杂芳基; R2和R3各自表示氢原子，卤素原子，羟基，羧基， - （C = O）aOb（C1-C6）烷基或 - （C = O）aN（R1e） R2e; R4表示氢原子或（C1-C6）烷基等具有优异的Wee1激酶抑制作用，因此可用于医学领域，特别是在各种癌症治疗领域。