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公开(公告)号：US20130052217A1
公开(公告)日：2013-02-28
申请号：US13634696
申请日：2011-03-09
申请人： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
发明人： Thorsten Klamp , Ugur Sahin , Ozlem Tureci , Michael Koslowski , Thomas Hiller , Jens Schumacher
IPC分类号： C07K19/00 , C12N15/63 , C12N1/21 , C12N1/19 , A61P35/00 , C12N5/10 , A61K39/29 , A61K31/7088 , A61P37/04 , C12N15/62 , C12N1/00
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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公开(公告)号：US20100111975A1
公开(公告)日：2010-05-06
申请号：US12531267
申请日：2008-03-14
申请人： Ugur Sahin , Michael Koslowski , Ozlem Tureci
发明人： Ugur Sahin , Michael Koslowski , Ozlem Tureci
IPC分类号： A61K39/395 , C12N5/16 , C07K16/00 , A61P35/00
CPC分类号： C07K16/30 , C07K16/18 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关疾病（包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌和肝细胞癌）的治疗剂的抗体。
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公开(公告)号：US20080166350A1
公开(公告)日：2008-07-10
申请号：US11596649
申请日：2005-05-18
申请人： Ozlem Tureci , Ugur Sahin , Michael Koslowski
发明人： Ozlem Tureci , Ugur Sahin , Michael Koslowski
IPC分类号： A61K39/395 , C07H21/04 , A61K39/00 , C12Q1/68 , C12N5/00 , C07K14/435 , C07K17/00 , C07K2/00 , C12N15/00 , A61P35/04 , C07K16/00
CPC分类号： A61K6/00 , A61K47/6851 , A61K49/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C12N9/88 , C12Y406/01002 , G01N33/57496
摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US20060013817A1
公开(公告)日：2006-01-19
申请号：US10506443
申请日：2003-03-12
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US20150337052A1
公开(公告)日：2015-11-26
申请号：US14821411
申请日：2015-08-07
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： C07K16/30
CPC分类号： C07K16/3076 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
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公开(公告)号：US20140127219A1
公开(公告)日：2014-05-08
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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公开(公告)号：US20090208498A1
公开(公告)日：2009-08-20
申请号：US12423153
申请日：2009-04-14
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。
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公开(公告)号：US07429461B2
公开(公告)日：2008-09-30
申请号：US10506443
申请日：2003-03-12
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： G01N33/574
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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19.发明申请公开(公告)号：US20060035852A1
公开(公告)日：2006-02-16
申请号：US10537002
申请日：2003-11-21
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K48/00
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. Said invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for said polypeptides, peptides and proteins.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于编码所述产物的核酸。 所述发明还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码所述多肽，肽和蛋白质的核酸 。
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公开(公告)号：US09718886B2
公开(公告)日：2017-08-01
申请号：US13808423
申请日：2011-07-04
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.
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