摘要:
The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods.
摘要:
Polyetherpolycarbonatediols are composed essentially ofA) from 3 to 63.7 mol % of units derived from a polyoxytetramethylenediol,B) from 63.7 to 3 mol % of units derived from a polyoxy-C.sub.2 -C.sub.8 -alkylenediol other than A), an aliphatic alkanediol of from 2 to 14 carbon atoms, an alicyclic alkanediol of from 3 to 14 carbon atoms or an alkylene oxide of 2 to 3 carbon atoms, or a mixture thereof, andC) from 33.3 to 50 mol % of units derived from phosgene, a dialkyl carbonate having C.sub.1 -C.sub.4 -alkyl groups or a cyclic carbonate having C.sub.2 -C.sub.4 -alkylene bridges, or a mixture thereof.
摘要:
Substituted indole derivatives of formula (I) wherein the radicals have e.g. the following meaning: R1 is hydrogen, C1-6-alkyl, R2 is hydrogen, —C1-6-alkyl or cycloC3-12-alkyl; R3 is OR R4 is hydrogen or halogen, R5 is hydrogen, —C1-6-alkyl R6 is hydrogen, —C1-6-alkyl R is hydrogen or —C1-6-alkyl; X is a group —C(O)CH2— or —CH═CH—; R7 is hydrogen are potent inhibitors of Abeta peptide polymerization and can be used for the treatment of e.g. Alzheimers disease or ocular disorders.
摘要:
The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases.
摘要:
The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases.
摘要:
The invention relates to novel fredericamycin derivatives of general formula (Ia) or (Ib), to medicaments containing the fredericamycin derivatives or salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially tumor diseases.
摘要:
The invention relates to novel fredericamycin derivatives of general formula (Ia) or (Ib), to medicaments containing said derivatives or the salts of the same, and to the use of said fredericamycin derivatives for treating diseases, especially tumour diseases.
摘要:
In thermoplastic elastomers selected from the group consisting of the thermoplastic polyurethanes, of the polyetheresters and of the polyetheramides which are derived from polyetherpolycarbonatediols as diol components, the polyetherpolycarbonatediols used are reaction products of phosgene, dialkyl carbonates having C.sub.1 -C.sub.4 -alkyl groups or cyclic carbonates having C.sub.2 -C.sub.4 -alkylene bridges or mixtures thereof with mixtures ofa.sub.1) from 10 to 100 mol % of polyoxytetramethylenediol having a number average molecular weight M.sub.n of from 150 to 500 anda.sub.2) from 0 to 90 mol % of polyoxyalkylenediols which differ from a.sub.1) and have C.sub.2 -C.sub.8 -alkylene groups, aliphatic alkanediols of 2 to 14 carbon atoms, alicyclic alkanediols of 3 to 14 carbon atoms or alkylene oxides of 2 or 3 carbon atoms, or mixtures thereof.
摘要:
This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme
摘要:
A method and apparatus are disclosed for adjusting the bandwidth of a connection between at least two communication endpoints in a data network via a monitoring unit and a control unit. The connection in the data network is assigned at least one transmission channel for data transmission. The user data is, in this case, allocated to at least one communication connection; in particular a voice connection. The monitoring unit monitors the signaling connection for requests for at least one further communication connection; in particular, a voice connection. When a request occurs, it signals to the control unit to assign to the connection one or more additional free transmission channels for the at least one requested communication connection.