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公开(公告)号:US20180229038A1
公开(公告)日:2018-08-16
申请号:US15940473
申请日:2018-03-29
申请人: California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人: Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, JR. , Yangsheng Chen
IPC分类号: A61N1/36 , A61N1/05 , A61B5/00 , A61B5/11 , A61B5/0492
CPC分类号: A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
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公开(公告)号:US20160067777A1
公开(公告)日:2016-03-10
申请号:US14941055
申请日:2015-11-13
CPC分类号: B22F1/0018 , B22F9/24 , B22F2301/255 , B22F2304/05 , C01G7/00 , C01P2002/82 , C01P2004/03 , C01P2004/04 , C01P2004/32
摘要: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
摘要翻译: 本文公开的实施方案涉及用限定的等离子体共振合成自组装纳米颗粒的方法。 更具体地,本文公开的某些实施方案涉及用于通过在自组装过程期间或在表面存在下透析样品来合成自组装金纳米颗粒以减少某些亚群的改进方法。
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公开(公告)号:US11007368B2
公开(公告)日:2021-05-18
申请号:US15752280
申请日:2016-08-18
发明人: Susan J. Harkema , Yangshen Chen , Robert S. Keynton , Douglas J. Jackson , John Naber , Thomas Roussel , Manikandan Ravi
摘要: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.
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公开(公告)号:US10737095B2
公开(公告)日:2020-08-11
申请号:US15940473
申请日:2018-03-29
申请人: California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人: Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, Jr. , Yangsheng Chen
IPC分类号: A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0492 , A61B5/11
摘要: Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
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公开(公告)号:US10022791B2
公开(公告)日:2018-07-17
申请号:US14941055
申请日:2015-11-13
摘要: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
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公开(公告)号:US20160310739A1
公开(公告)日:2016-10-27
申请号:US15199580
申请日:2016-06-30
申请人: California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人: Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangsheng Chen
CPC分类号: A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要: Neurostimulator devices and methods of using these devices are described. The neurostimulator devices can include a stimulation assembly connectable to a plurality of electrodes; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern.
摘要翻译: 描述神经刺激装置和使用这些装置的方法。 神经刺激器装置可以包括可连接到多个电极的刺激组件; 一个或多个传感器; 以及配置成修改至少一个复杂刺激模式的至少一个处理器。
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公开(公告)号:US09463019B2
公开(公告)日:2016-10-11
申请号:US14279765
申请日:2014-05-16
CPC分类号: A61B17/08 , A61B17/0057 , A61B2017/00592 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637 , A61B2017/081
摘要: Embodiments of this invention relate to trocar site closures including a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Embodiments of this invention also relate to an insertion device used to insert the closure into the wound and at least partially close the wound.
摘要翻译: 本发明的实施例涉及套管针位置闭合,其包括具有多个臂接收通道的头部,由每个通道接收的臂,每个通道具有不连续性,其允许每个臂向内拉动但阻止向外移动,并且每个 臂具有抓钩部分。 头部和手臂插入患者伤口,如套管针部位。 手臂与伤口周围的组织接合。 牵引力作用在臂的近端,将臂的远端朝头部拉出并且至少部分地闭合伤口。 头部和至少一部分臂保持在患者体内,并且优选地由生物相容性材料制成。 本发明的实施例还涉及用于将闭合件插入伤口并且至少部分地闭合伤口的插入装置。
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公开(公告)号:US20150231396A1
公开(公告)日:2015-08-20
申请号:US14604625
申请日:2015-01-23
申请人: California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人: Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Johnathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca
IPC分类号: A61N1/36
CPC分类号: A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要: A neurostimulator devices and systems for use with groups of electrodes placed within a subject's body. The devices and systems can include training devices and/or pulse generation systems.
摘要翻译: 一种神经刺激器装置和系统,用于放置在受试者体内的电极组。 装置和系统可以包括训练装置和/或脉冲发生系统。
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公开(公告)号:US20140343603A1
公开(公告)日:2014-11-20
申请号:US14279765
申请日:2014-05-16
IPC分类号: A61B17/08
CPC分类号: A61B17/08 , A61B17/0057 , A61B2017/00592 , A61B2017/00619 , A61B2017/00623 , A61B2017/00637 , A61B2017/081
摘要: Disclosed herein are trocar site closures, comprising a head with a plurality of arm receiving passages therethrough, an arm received by each of the passages, each passage having a discontinuity which allows each arm to be pulled inward but deters outward movement, and each arm having a grappling portion. The head and arms are inserted into a patient wound, such as a trocar site. The arms engage with tissue surrounding the wound. A pulling force is exerted on the arm proximal ends, drawing the distal ends of the arms toward the head and at least partially closing the wound. The head and at least a portion of the arms remain in the patient, and are preferably made of a biocompatible material. Also disclosed herein is an insertion device used to insert the closure into the wound and at least partially close the wound.
摘要翻译: 本文公开了一种套管针关闭装置,其包括具有穿过其中的多个臂接收通道的头部,由每个通道容纳的臂,每个通道具有允许每个臂向内拉以阻止向外运动的不连续性,并且每个臂具有 抓钩部分。 头部和手臂插入患者伤口,如套管针部位。 手臂与伤口周围的组织接合。 牵引力作用在臂的近端,将臂的远端朝头部拉出并且至少部分地闭合伤口。 头部和至少一部分臂保持在患者体内,并且优选地由生物相容性材料制成。 本文还公开了用于将闭合件插入伤口并且至少部分地闭合伤口的插入装置。
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公开(公告)号:US11986176B2
公开(公告)日:2024-05-21
申请号:US17059354
申请日:2019-06-11
发明人: Scott D. Cambron , Daniel S. Metzinger , Robert S. Keynton , Hares A. Patel , Dakota J. Waldecker
IPC分类号: A61B17/00
CPC分类号: A61B17/0057 , A61B2017/00004 , A61B2017/00584 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668
摘要: A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patients tissue. The biodegradable clip remains in the patients tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.
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