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公开(公告)号：US20210228885A1
公开(公告)日：2021-07-29
申请号：US17230280
申请日：2021-04-14
发明人： Susan J. Harkema , Yangshen Chen , Robert S. Keynton , Douglas J. Jackson , John Naber , Thomas Roussel , Manikandan Ravi
摘要： Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.
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公开(公告)号：US20210082123A1
公开(公告)日：2021-03-18
申请号：US17050269
申请日：2019-04-26
发明人： Ayman S. El-Baz , Ahmed Soliman , Ahmed Eltanboly , Ahmed Sleman , Robert S. Keynton , Harpal Sandhu , Andrew Switala
IPC分类号： G06T7/143
摘要： A method for segmentation of a 3-D medical image uses an adaptive patient-specific atlas and an appearance model for 3-D Optical Coherence Tomography (OCT) data. For segmentation of a medical image of a retina, In order to reconstruct the 3-D patient-specific retinal atlas, a 2-D slice of the 3-D image containing the macula mid-area is segmented first. A 2-D shape prior is built using a series of co-aligned training OCT images. The shape prior is then adapted to the first order appearance and second order spatial interaction MGRF model of the image data to be segmented. Once the macula mid-area is segmented into separate retinal layers this initial slice, the segmented layers' labels and their appearances are used to segment the adjacent slices. This step is iterated until the complete 3-D medical image is segmented.
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公开(公告)号：US10058818B2
公开(公告)日：2018-08-28
申请号：US14722791
申请日：2015-05-27
CPC分类号： B01D53/326 , B01D53/229 , B01D2257/104
摘要： Present embodiments provide an energy-efficient separator having at least two chambers fluidically isolated by a gas permeable membrane for the removal of dissolved gases from a sample which, in some aspects, enables cost-effective monitoring of liquid samples to be performed remotely and automatically, and in other aspects is suited for various other applications where removal and/or regulation of gases in a sample are desirable.
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公开(公告)号：US20240260955A1
公开(公告)日：2024-08-08
申请号：US18638861
申请日：2024-04-18
发明人： Scott D. Cambron , Daniel S. Metzinger , Robert S. Keynton , Hares A. Patel , Dakota J. Waldecker
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00584 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668
摘要： A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patient's tissue. The biodegradable clip remains in the patient's tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.
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公开(公告)号：US11691016B2
公开(公告)日：2023-07-04
申请号：US17048955
申请日：2019-04-19
发明人： Susan J. Harkema , Yangsheng Chen , Claudia Angeli , Douglas J. Jackson , Manikandan Ravi , John Naber , Robert S. Keynton , Thomas Roussel , Saliya Kirigeeganage
IPC分类号： A61N1/36
CPC分类号： A61N1/36175 , A61N1/36062
摘要： Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.
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公开(公告)号：US20210212673A1
公开(公告)日：2021-07-15
申请号：US17059354
申请日：2019-06-11
发明人： Scott D. Cambron , Daniel S. Metzinger , Robert S. Keynton , Hares A. Patel , Dakota J. Waldecker
IPC分类号： A61B17/00
摘要： A trocar site closure clip includes a generally triangular central body, a pair of arms extending from the body, and an elongated support extending from the body between the arms. In use, the clip is advanced into a patient through a trocar, the trocar removed, then the clip partially retracted to engage and pierce the patients tissue. The biodegradable clip remains in the patients tissue, at least partially blocking the trocar site, and degrades over time as the patient heals.
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公开(公告)号：US10191009B2
公开(公告)日：2019-01-29
申请号：US15061194
申请日：2016-03-04
IPC分类号： G01N27/42
摘要： Methods and sensing instruments are provided which perform automated electrochemical sensing and determination of metals in a liquid sample, such as drinking water or waste water. With use of microelectrode arrays, concentrations of metal are determined through a double potential step variation on anodic stripping coulometry, and the ability to generate these results provides for compact sensor networks that can be remotely deployed for determination of metals in samples, for real-time, decentralized sample monitoring.
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公开(公告)号：US20180236241A1
公开(公告)日：2018-08-23
申请号：US15752280
申请日：2016-08-18
发明人： Susan J. Harkema , Yangshen Chen , Robert S. Keynton , Douglas J. Jackson , John Naber , Thomas Roussel , Manikandan Ravi
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/3605 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36171
摘要： Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.
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公开(公告)号：US20210228884A1
公开(公告)日：2021-07-29
申请号：US17048955
申请日：2019-04-19
发明人： Susan J. Harkema , Yangsheng Chen , Claudia Angeli , Douglas J. Jackson , Manikandan Ravi , John Naber , Robert S. Keynton , Thomas Roussel , Saliya Kirigeeganage
IPC分类号： A61N1/36
摘要： Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.
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公开(公告)号：US20180229038A1
公开(公告)日：2018-08-16
申请号：US15940473
申请日：2018-03-29
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, JR. , Yangsheng Chen
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/11 , A61B5/0492
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
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