公开(公告)号：US10718022B2

公开(公告)日：2020-07-21

申请号：US15566533

申请日：2016-04-15

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

公开(公告)号：US10130679B2

公开(公告)日：2018-11-20

申请号：US15074714

申请日：2016-03-18

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Guangping Gao ,  Manas Kumar Santra ,  Sanchita Bhatnagar

IPC: A61K38/17 ,  A61K38/16 ,  A61K48/00 ,  A61K35/12 ,  C12N9/08

Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.

公开(公告)号：US20250115593A1

公开(公告)日：2025-04-10

申请号：US18904487

申请日：2024-10-02

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  University of Massachusetts

Inventor： John A. PORCO, Jr. ,  Zihao WANG ,  Lauren E. BROWN ,  Stanley I. Goldstein ,  Sunll K. MALONIA ,  Ritesh P. THAKARE ,  Alok K. MISHRA ,  Michael R. Green

IPC: C07D413/12 ,  A61K31/343 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/4525 ,  A61K31/5377 ,  A61P35/00 ,  C07D307/93 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

公开(公告)号：US11963975B2

公开(公告)日：2024-04-23

申请号：US17489983

申请日：2021-09-30

Applicant: University of Massachusetts

Inventor： Peter L. Jones ,  Michael R. Green

IPC: C12N15/113 ,  A61K31/5513 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/90 ,  G01N33/50

CPC classification number: A61K31/7105 ,  A61K31/5513 ,  A61K31/713 ,  A61K45/06 ,  C12N15/113 ,  C12N15/90 ,  G01N33/5061 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2740/16043

Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).

公开(公告)号：US20200276266A1

公开(公告)日：2020-09-03

申请号：US16815356

申请日：2020-03-11

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Guangping Gao ,  Manas Kumar Santra ,  Sanchita Bhatnagar

IPC: A61K38/17 ,  A61K38/16 ,  A61K48/00 ,  A61K35/12 ,  C12N9/08

Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.

公开(公告)号：US20180256749A1

公开(公告)日：2018-09-13

申请号：US15760765

申请日：2016-09-16

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang ,  Walter Kowtoniuk

IPC: A61K48/00 ,  A61K31/496 ,  A61K31/713 ,  A61K31/549 ,  A61K31/706 ,  A61K31/5377 ,  A61K39/395 ,  A61K38/45 ,  A61K38/53 ,  A61K31/711 ,  A61K31/7105 ,  A61K35/30 ,  C12N15/113 ,  C12Q1/6883 ,  A61P25/14 ,  A61P15/02

CPC classification number: A61K48/005 ,  A61K31/167 ,  A61K31/404 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/546 ,  A61K31/549 ,  A61K31/706 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K35/30 ,  A61K38/45 ,  A61K38/53 ,  A61K39/3955 ,  A61K48/0016 ,  A61P15/02 ,  A61P25/14 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12Q1/6883 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01037 ,  C12Y201/01043 ,  C12Y603/02019

Abstract: The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene. In some aspects, methods described by the disclosure are useful for treating a FMR1-inactivation-associated disorder (e.g., fragile X syndrome).

公开(公告)号：US20180087110A1

公开(公告)日：2018-03-29

申请号：US15566533

申请日：2016-04-15

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

公开(公告)号：US20170183741A1

公开(公告)日：2017-06-29

申请号：US15308673

申请日：2015-05-14

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Leyuan Ma

IPC: C12Q1/68 ,  A61K31/506 ,  A61K31/519 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  A61K31/506 ,  A61K31/519 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57426 ,  G01N2333/91205 ,  G01N2800/52

Abstract: Methods for treating chronic myeloid leukemia (CML), e.g., BCR-ABL inhibitor imatinib mesylate (IM)-resistant CML, using combination treatments, e.g., combined treatment with a BCR-ABL inhibitor, e.g., IM, and a MEK inhibitor, e.g., trametinib.

公开(公告)号：US11819554B2

公开(公告)日：2023-11-21

申请号：US15760765

申请日：2016-09-16

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Minggang Fang ,  Walter Kowtoniuk

IPC: A61K31/711 ,  A61K35/30 ,  A61K38/45 ,  A61K38/53 ,  A61K39/395 ,  A61K48/00 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/706 ,  A61K31/713 ,  C12Q1/6883 ,  C12N15/113 ,  A61K31/7088 ,  A61K31/404 ,  A61K31/546 ,  A61K31/167 ,  A61K31/497 ,  A61K31/506 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/522 ,  A61K31/496 ,  A61P25/14 ,  A61P15/02 ,  A61K31/7105

CPC classification number: A61K48/005 ,  A61K31/167 ,  A61K31/404 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/546 ,  A61K31/549 ,  A61K31/706 ,  A61K31/7088 ,  A61K31/711 ,  A61K31/713 ,  A61K31/7105 ,  A61K35/30 ,  A61K38/45 ,  A61K38/53 ,  A61K39/3955 ,  A61K48/0016 ,  A61P15/02 ,  A61P25/14 ,  C12N15/113 ,  C12Q1/6883 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y201/01037 ,  C12Y201/01043 ,  C12Y603/02019

Abstract: The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene. In some aspects, methods described by the disclosure are useful for treating a FMR1-inactivation-associated disorder (e.g., fragile X syndrome).

公开(公告)号：US20220259654A1

公开(公告)日：2022-08-18

申请号：US17585765

申请日：2022-01-27

Applicant: University of Massachusetts

Inventor： Michael R. Green ,  Sanchita Bhatnagar

IPC: C12Q1/6883 ,  G01N33/50

Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.