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    SYSTEMS AND METHODS FOR IN VIVO VISUALIZATION OF LYMPHATIC VESSELS WITH OPTICAL COHERENCE TOMOGRAPHY
    12.
    发明申请
    SYSTEMS AND METHODS FOR IN VIVO VISUALIZATION OF LYMPHATIC VESSELS WITH OPTICAL COHERENCE TOMOGRAPHY 审中-公开
    用光学相干光谱法检测血管内皮生长因子的体系及方法

    公开(公告)号：US20160000368A1

    公开(公告)日：2016-01-07

    申请号：US14789291

    申请日：2015-07-01

    Applicant: University of Washington

    Inventor： Ruikang K. Wang ,  Siavash Yousefi ,  Utku Baran

    IPC: A61B5/00 ,  A61B5/0275 ,  A61B5/026

    CPC classification number: A61B5/418 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0261 ,  A61B5/725

    Abstract: The present technology relates generally to systems and methods for in vivo visualization of lymphatic vessels. A system includes an optical coherence tomography (OCT) device and a computing device coupled to the OCT device configured to cause the OCT device to perform an OCT scan, generate image data in response to the OCT scan, and apply an eigendecomposition filter to the image data to produce processed image data. Alternatively or in addition, the computing device can compensate for scattering attenuation along an optical axis of the OCT scan in the image data set to generate compensated image data, enhance contrast of the compensated image data along a cross-section substantially orthogonal to the optical axis to generate contrast-enhanced image data, and identify at least one lymphatic vessel in the image data.

    Abstract translation: 本技术一般涉及淋巴管体内可视化的系统和方法。 一种系统包括光学相干断层摄影（OCT）设备和耦合到OCT设备的计算设备，该设备被配置为使得OCT设备执行OCT扫描，响应于OCT扫描生成图像数据，并将图像分解滤波器应用于图像 数据产生经处理的图像数据。 或者或另外，计算设备可以补偿沿着图像数据集中的OCT扫描的光轴的散射衰减，以产生补偿的图像数据，增强补偿的图像数据沿着与光轴基本正交的横截面的对比度 以产生对比度增强的图像数据，并且识别图像数据中的至少一个淋巴管。

    Methods for Laser Speckle Contrast Imaging of Blood Perfusion
    13.
    发明申请
    Methods for Laser Speckle Contrast Imaging of Blood Perfusion 有权
    激光斑点对比成像血液灌注方法

    公开(公告)号：US20140357990A1

    公开(公告)日：2014-12-04

    申请号：US14289999

    申请日：2014-05-29

    Applicant: University of Washington through its Center for Commercialization

    Inventor： Ruikang K. Wang

    IPC: A61B5/026 ,  A61B5/00

    CPC classification number: A61B5/0261 ,  A61B5/445 ,  A61B5/7246 ,  A61B5/7257 ,  G02B27/48

    Abstract: A method for imaging blood flow through target tissue is disclosed. An example method may include (a) directing a light beam at a blood-perfused target tissue, (b) reflecting the directed light beam off of static target tissue and flowing cells, (c) capturing a plurality of digital images of interference patterns of the reflected light in a plurality of successive frames, (d) measuring a light intensity of at least one pixel of each digital image, where the at least one pixel corresponds to an identical pair of coordinates in each successive frame, (e) comparing the measured light intensity of the at least one pixel of each digital image to the measured light intensity of the at least one pixel of an adjacent frame at the identical pair of coordinates and (f) determining a compiled light intensity for the at least one pixel for an aggregate motion contrast.

    Abstract translation: 公开了一种用于对通过目标组织的血流进行成像的方法。 示例性方法可以包括（a）在血液灌注的目标组织处引导光束，（b）将定向光束反射离开静态目标组织和流动细胞，（c）捕获多个数字图像的干涉图案 多个连续帧中的反射光，（d）测量每个数字图像的至少一个像素的光强度，其中至少一个像素对应于每个连续帧中的相同坐标对，（e）将 将每个数字图像的至少一个像素的光强度测量为在相同坐标系对的相邻帧的至少一个像素的测量光强度，以及（f）确定所述至少一个像素的编辑光强度 总体运动对比。

    HANDHELD OPTICAL IMAGING DEVICES AND METHODS
    15.
    发明申请
    HANDHELD OPTICAL IMAGING DEVICES AND METHODS 有权

    公开(公告)号：US20220183553A1

    公开(公告)日：2022-06-16

    申请号：US17593999

    申请日：2020-03-27

    Applicant: University of Washington

    Inventor： Ruikang K. Wang ,  Shaozhen Song

    IPC: A61B3/10 ,  A61B3/12 ,  A61B3/00

    Abstract: Handheld optical imaging devices and methods are disclosed herein. In an embodiment, an optical coherence tomography (OCT) system includes an OCT probe that is configured as a hand-held probe for imaging an eye of a patient, the OCT probe includes: an OCT optical system configured to direct a source OCT signal to the eye and configured to capture OCT scan signal returning from the eye; and an on-probe display carried by a handle, wherein the on-probe display is configured to display imaging data of the eye of a patient to an operator during OCT imaging.

    METHODS AND SYSTEMS FOR DETERMINING VOLUMETRIC PROPERTIES OF A TISSUE
    18.
    发明申请
    METHODS AND SYSTEMS FOR DETERMINING VOLUMETRIC PROPERTIES OF A TISSUE 审中-公开
    用于确定组织体积特性的方法和系统

    公开(公告)号：US20150230708A1

    公开(公告)日：2015-08-20

    申请号：US14421926

    申请日：2013-08-23

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Ruikang K. Wang ,  Murray Johnstone

    IPC: A61B5/00 ,  A61B3/10 ,  A61B3/12

    CPC classification number: A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0073 ,  A61B5/14555 ,  A61B5/7278

    Abstract: Systems and methods for determining microvascular functions in a sample of a subject are provided. A system obtains one or more spectral interference signals from the sample during one or more scans, extracts data from the spectral interference signals concerning cell, tissue, or particle motion within the sample via one or more optical microangiography algorithms, and calculates volumetric properties from the data indicative of fluid motion within the sample. The system and method may be used for diagnosing, providing a prognosis, or monitoring treatment of a disorder of the sample.

    Abstract translation: 提供了用于确定受试者样品中的微血管功能的系统和方法。 系统在一次或多次扫描期间从样本获得一个或多个光谱干涉信号，通过一个或多个光学微血管造影术从样本中的关于细胞，组织或粒子运动的光谱干涉信号中提取数据，并从 指示样品内流体运动的数据。 该系统和方法可用于诊断，提供预后或监测样品病症的治疗。

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