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公开(公告)号：US09743909B1
公开(公告)日：2017-08-29
申请号：US14278197
申请日：2014-05-15
Inventor： Oleg A. Sapozhnikov , Michael R. Bailey , Joo Ha Hwang , Tatiana D. Khokhlova , Vera Khokhlova , Matthew O'Donnell , Tong Li
CPC classification number: A61B8/481 , A61B5/0051 , A61B5/0062 , A61B5/0507 , A61N7/00
Abstract: A method for imaging a cavitation bubble includes producing a vibratory wave that induces a cavitation bubble in a medium, producing one or more detection waves directed toward the induced cavitation bubble, receiving one or more reflection waves, identifying a change in one or more characteristics of the induced cavitation bubble, and generating an image of the induced cavitation bubble using a computing device on the basis of the identified change in the one or more characteristics. The one or more received reflection waves correspond to at least one of the one or more produced detection waves reflection from the induced cavitation bubble. The identified change in one or more characteristics corresponds to the one or more received reflection waves.
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公开(公告)号：US20170079622A1
公开(公告)日：2017-03-23
申请号：US15308828
申请日：2015-05-11
Applicant: University of Washington
Inventor： Matthew O'Donnell , Thu-Mai Nguyen , Chen-Wei Wei , Jinjun Xia
CPC classification number: A61B8/5261 , A61B5/0035 , A61B5/0095 , A61B8/0841 , A61B8/14 , A61B8/4416 , A61B8/4483 , A61B8/463
Abstract: Methods and system for producing combined photoacoustic/ultrasonic image frames use a low-power narrow beam laser to direct sequential pulses along a path overlying an internal region of interest. Photoacoustic responses are received and used to generate sub-frames. Between each of the laser pulses a plurality of ultrasound pulse-echo beams are sequentially emitted towards the region of interest, and the reflections are received and used to generate ultrasound sub-frames. The photoacoustic sub-frames are combined to produce a photoacoustic frame, and the ultrasound sub-frames are combined to produce an ultrasound frame. The photoacoustic and ultrasound frames are combined to produce an image frame. The method and system are suitable for producing real-time, high-contrast video.
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公开(公告)号：US20150231282A1
公开(公告)日：2015-08-20
申请号：US14432974
申请日：2013-10-01
Inventor： Lilo Danielle Pozzo , Matthew O'Donnell , Thomas J. Matula , Kjersta Larson-Smith , Chen-wei Wei , Ivan Pelivanov , Jinjun Xia
CPC classification number: A61K49/226 , A61K9/107 , A61K31/28 , A61K41/0028 , A61K41/0052 , A61K47/6907 , A61K49/222 , A61M37/0092 , A61M2037/0007 , A61N5/062
Abstract: Composites formed from a liquid core encapsulated by a plurality of nanoparticles are provided herein. The composites in certain embodiments are droplets comprising a hydrophobic dispersed phase within a hydrophilic continuous phase, thereby forming an emulsion. The composites can be used as contrast agents for imaging, therapeutic agents, and adapted for other uses according to the unique properties of the composites disclosed herein.
Abstract translation: 本文提供了由由多个纳米颗粒包封的液芯形成的复合材料。 在某些实施方案中的复合材料是在亲水连续相内包含疏水分散相的液滴，从而形成乳液。 根据本文公开的复合材料的独特性质，复合材料可用作成像，治疗剂的造影剂，并适用于其它用途。
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4.发明授权公开(公告)号：US11073500B2
公开(公告)日：2021-07-27
申请号：US16183229
申请日：2018-11-07
Applicant: The Boeing Company , University of Washington
Inventor： Jill P. Bingham , Gary E. Georgeson , William P. Motzer , Alan F. Stewart , Matthew O'Donnell , Ivan Pelivanov
IPC: G01N29/22 , G01N29/24 , G01N29/265 , G01N21/17 , G01N29/11
Abstract: A method for testing a structure using laser ultrasound includes steps of: (1) directing positioning light on a surface of the structure; (2) determining a spatial location and a spatial orientation of the surface from an evaluation of the positioning light reflected back from the surface; (3) directing pump light onto the surface to generate ultrasonic waves in the structure; (4) selectively locating a probe-light focal point of probe light on the surface, based on the spatial location determined for the surface; (5) selectively angularly orienting the probe light normal to the surface, based on the spatial orientation determined for the surface; and (6) directing the probe light onto the surface to detect a response to the ultrasonic waves.
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公开(公告)号：US20190307908A1
公开(公告)日：2019-10-10
申请号：US16374502
申请日：2019-04-03
Applicant: University of Washington
Inventor： Lilo D. Pozzo , David Li , Yi-Ting Lee , Matthew O'Donnell
Abstract: The present disclosure features, a kit, including a first compartment including a volatile fluorinated compound dissolved in a C1-6 alcohol; and a second compartment including water. When the contents of the first and second compartments are mixed, spontaneous nucleation of nanodroplets of the volatile fluorinated compound can form in the aqueous phase to provide a dispersion of nanodroplets in the aqueous phase. The nanodroplets can be used to generate nanobubbles or microbubbles in ultrasound imaging.
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Patent Agency Ranking
公开(公告)号：US20190302007A1
公开(公告)日：2019-10-03
申请号：US16368668
申请日：2019-03-28
Applicant: University of Washington
Inventor： Ivan Pelivanov , Matthew O'Donnell , Elena Petrova , Soon Joon Yoon
Abstract: A non-contact photoacoustic spectrophotometry system is configured to measure an absorption spectrum of a material. The system includes a modulated light source such as tunable pulsed laser that generates laser pulses to produce photoacoustic signals in the material. A non-contact detector monitors the surface of the container for the material. The detector includes a second light source, such as a continuous wave laser, focused on the surface of the container, and transmits reflected light to an interferometer, for example, a Sagnac interferometer. The interferometer produces an interference signal from the received light that is proportional to the acoustic pressure, which is transmitted to a computer to calculate an absorption coefficient. Using a plurality of wavelengths from the tunable pulsed laser, an absorption spectrum may be generated.
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公开(公告)号：US20190034568A1
公开(公告)日：2019-01-31
申请号：US16144956
申请日：2018-09-27
Inventor： Ivan Pelivanov , Matthew O'Donnell , Abraham Vereide
CPC classification number: G06F17/5009 , E21B47/0005 , E21B47/082 , G01V1/282 , G01V1/50
Abstract: Systems and methods process a measured ultrasonic response waveform to determine a well casing thickness and an acoustic impedance of a sealing medium surrounding the well casing. An array of simulated response waveforms corresponding to a set of candidate acoustic impedances for the sealing medium surrounding the well casing and a set of candidate well casing thicknesses is generated. A simulated response waveform from the array of simulated response waveforms is identified that best matches the measured response waveform so as to determine the sealing medium acoustic impedance.
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公开(公告)号：US10126273B2
公开(公告)日：2018-11-13
申请号：US15056684
申请日：2016-02-29
Applicant: The Boeing Company , University of Washington
Inventor： Ivan Pelivanov , William P. Motzer , Matthew O'Donnell , Steven Kenneth Brady , Gary Ernest Georgeson , Jeffrey Reyner Kollgaard , Clarence Lavere Gordon, III , Jill Paisley Bingham , Alan F. Stewart , James C. Kennedy
IPC: G01N29/04 , G01N29/22 , G01N29/24 , G01N29/265 , G01N29/07
Abstract: A method of detecting inconsistencies in a structure is presented. A pulsed laser beam is directed towards the structure. A plurality of types of ultrasonic signals is formed in the structure when radiation of the pulsed laser beam is absorbed by the structure. The plurality of types of ultrasonic signals is detected to form data.
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公开(公告)号：US10599790B2
公开(公告)日：2020-03-24
申请号：US16144956
申请日：2018-09-27
Inventor： Ivan Pelivanov , Matthew O'Donnell , Abraham Vereide
Abstract: Systems and methods process a measured ultrasonic response waveform to determine a well casing thickness and an acoustic impedance of a sealing medium surrounding the well casing. An array of simulated response waveforms corresponding to a set of candidate acoustic impedances for the sealing medium surrounding the well casing and a set of candidate well casing thicknesses is generated. A simulated response waveform from the array of simulated response waveforms is identified that best matches the measured response waveform so as to determine the sealing medium acoustic impedance.
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公开(公告)号：US10571390B2
公开(公告)日：2020-02-25
申请号：US15070583
申请日：2016-03-15
Applicant: The Boeing Company , University of Washington
Inventor： William P. Motzer , Gary Ernest Georgeson , Jill Paisley Bingham , Steven Kenneth Brady , Alan F. Stewart , James C. Kennedy , Ivan Pelivanov , Matthew O'Donnell , Jeffrey Reyner Kollgaard
IPC: G01N21/17
Abstract: A method of detecting local material changes in a composite structure is presented. A pulsed laser beam is directed towards the composite structure comprised of a number of composite materials. Wide-band ultrasonic signals are formed in the composite structure when radiation of the pulsed laser beam is absorbed by the composite structure. The wide-band ultrasonic signals are detected to form data. The data is processed to identify a local frequency value for the composite structure. The local frequency value is used to determine if local material changes are present in the number of composite materials.
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