公开(公告)号：US11580945B2

公开(公告)日：2023-02-14

申请号：US16740320

申请日：2020-01-10

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/18 ,  G10K11/26 ,  A61B17/225 ,  G10K11/00 ,  G10K11/30 ,  G10K15/00 ,  G10K11/34 ,  G10K11/20 ,  G10K11/24 ,  H03H9/64 ,  A61B17/22

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20210038924A1

公开(公告)日：2021-02-11

申请号：US16927860

申请日：2020-07-13

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

Abstract: High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

公开(公告)号：US10694974B2

公开(公告)日：2020-06-30

申请号：US15120812

申请日：2015-03-27

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V.

Inventor： Ari Partanen ,  Vera Khokhlova ,  Navid Farr ,  Donghoon Lee ,  Wayne Kreider ,  Tatiana Khokhlova ,  Adam Maxwell ,  Yak-Nam Wang ,  George Schade ,  Michael Bailey

IPC: A61B5/055 ,  A61N7/02 ,  A61B5/01 ,  A61B5/00 ,  G01R33/28 ,  G01R33/48 ,  A61B90/00 ,  G01R33/50 ,  G01R33/563 ,  G01R33/56

Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

公开(公告)号：US20170072228A1

公开(公告)日：2017-03-16

申请号：US15126131

申请日：2015-03-30

Applicant: University of Washington

Inventor： Yak-Nam Wang ,  Michael R. Bailey ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  George R. Schade ,  Vera A. Khokhlova

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61N2007/0004 ,  A61N2007/0091

Abstract: Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“HIFU”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing HIFU waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ECM”) and generating, from nonlinear propagation of the HIFU waves, shock waves in the tissue to induce boiling in the volume of the tissue. The method can further include lysing cells in the volume of tissue while leaving the ECM at least substantially intact. The emulsification of cells can be to a sufficient degree to decellularize the tissue and form a decellularized scaffold for subsequent tissue growth.

Abstract translation: 本文公开了使用高强度聚焦超声（“HIFU”）治疗选择性地破坏组织的方法和系统。 根据本技术的实施例的治疗组织的方法可以包括例如将来自超声源的HIFU波脉冲到包括细胞外基质（“ECM”）的组织体积，并从 HIFU波，组织中的冲击波诱导组织体积沸腾。 该方法可以进一步包括裂解组织体内的细胞，同时离开ECM至少基本完整。 细胞的乳化可以足够的程度使组织脱细胞并形成用于随后组织生长的脱细胞支架。

公开(公告)号：US12167864B1

公开(公告)日：2024-12-17

申请号：US18151013

申请日：2023-01-06

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

公开(公告)号：US11583299B1

公开(公告)日：2023-02-21

申请号：US16295607

申请日：2019-03-07

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

公开(公告)号：US10251657B1

公开(公告)日：2019-04-09

申请号：US14268414

申请日：2014-05-02

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

公开(公告)号：US10598773B2

公开(公告)日：2020-03-24

申请号：US15446923

申请日：2017-03-01

Applicant: University of Washington

Inventor： Oleg A. Sapozhnikov ,  Wayne Kreider ,  Adam D. Maxwell ,  Vera Khokhlova

IPC: G03H3/00 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00 ,  A61N7/00 ,  A61N7/02

Abstract: The present technology relates generally to receiving arrays to measure a characteristic of an acoustic beam and associated systems and methods. The receiving arrays can include elongated elements having at least one dimension, such as a length, that is larger than a width of an emitted acoustic beam and another dimension, such as a width, that is smaller than half of a characteristic wavelength of an ultrasound wave. The elongated elements can be configured to capture waveform measurements of the beam based on a characteristic of the emitted acoustic beam as the acoustic beam crosses a plane of the array, such as a transverse plane. The methods include measuring at least one characteristic of an ultrasound source using an array-based acoustic holography system and defining a measured hologram at the array surface based, at least in part, on the waveform measurements. The measured hologram can be processed to reconstruct a characteristic of the ultrasound source. The ultrasound source can be calibrated and/or re-calibrated based on the characteristic.

公开(公告)号：US20170249932A1

公开(公告)日：2017-08-31

申请号：US15508841

申请日：2015-08-26

Applicant: Oleg A. SAPOZHNIKOV ,  Wayne KREIDER ,  Michael R. BAILEY ,  University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/00 ,  G10K11/30 ,  H03H9/64 ,  G10K11/20 ,  G10K11/24

CPC classification number: G10K11/008 ,  A61B17/225 ,  A61B17/2255 ,  A61B2017/22028 ,  G10K11/20 ,  G10K11/24 ,  G10K11/30 ,  G10K11/346 ,  G10K15/00 ,  H03H9/6483

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US09700742B2

公开(公告)日：2017-07-11

申请号：US14516442

申请日：2014-10-16

Applicant: University of Washington through its Center for Communication

Inventor： Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

IPC: A61B18/00 ,  A61N7/02 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61N7/02 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2090/374 ,  A61B2090/378

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.