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120 条记录 (耗时 0.055 秒)

    Neurostimulation to treat effects of sleep apnea
    12.
    发明授权
    Neurostimulation to treat effects of sleep apnea 有权
    神经刺激治疗睡眠呼吸暂停的效果

    公开(公告)号：US07155278B2

    公开(公告)日：2006-12-26

    申请号：US10419405

    申请日：2003-04-21

    申请人： Gary W. King ,  Marcus J. Mianulli ,  Michael R. S. Hill ,  Thomas J. Mullen ,  Roy L. Testerman ,  John E. Burnes ,  Xiaohong Zhou

    发明人： Gary W. King ,  Marcus J. Mianulli ,  Michael R. S. Hill ,  Thomas J. Mullen ,  Roy L. Testerman ,  John E. Burnes ,  Xiaohong Zhou

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3601 ,  A61N1/36017 ,  A61N1/36114

    摘要： Neurostimulation is delivered to one or more predetermined locations on or within a patient in order to treat effects of sleep apnea by modulating autonomic nervous activity. Delivery of neurostimulation at predetermined locations can decrease sympathetic nervous activity and/or increase parasympathetic nervous activity, countering the increased intrinsic sympathetic activity associated with apnea-arousal cycles. In some embodiments, neurostimulation is delivered to the spinal cord of the patient via an implanted electrode. In other embodiments, neurostimulation is delivered transcutaneously to the spinal cord or other locations via electrodes located on the surface of the patient. In some embodiments, delivery of neurostimulation is initiated or modified in response to detection of apneas.

    摘要翻译： 神经刺激被递送到患者体内或患者内的一个或多个预定位置，以通过调节自主神经活动来治疗睡眠呼吸暂停的影响。 在预定位置递送神经刺激可降低交感神经活动和/或增加副交感神经活动，抵抗与呼吸暂停 - 觉醒周期相关的增加的内在交感神经活动。 在一些实施方案中，神经刺激经由植入的电极递送至患者的脊髓。 在其他实施方案中，神经刺激通过位于患者表面上的电极经皮递送至脊髓或其它位置。 在一些实施方案中，响应于呼吸暂停的检测开始或修饰神经刺激的递送。

    METHOD AND APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC CONDITIONS
    14.
    发明申请
    METHOD AND APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC CONDITIONS 有权
    用于电刺激神经系统以改善心脏功能障碍，心脏衰竭和其他心脏病症的方法和装置

    公开(公告)号：US20100016919A1

    公开(公告)日：2010-01-21

    申请号：US12565910

    申请日：2009-09-24

    申请人： Michael R.S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

    发明人： Michael R.S. Hill ,  Gary W. King ,  Thomas J. Mullen ,  Xiaohong Zhou

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36114 ,  A61N1/3627

    摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.

    摘要翻译： 使用方法和装置为患有心室功能障碍或心力衰竭的患者提供治疗。 至少一个电极位于与患者体内的神经组织如神经束T1-T4相关联的区域中。 电刺激被施加到至少一个电极以改善患者心脏的心脏效率。 监测患者的一个或多个预定生理参数，并且基于一个或多个预定生理参数来调整电刺激。

    Methods and apparatus for the regulation of hormone release
    15.
    发明授权
    Methods and apparatus for the regulation of hormone release 有权
    用于调节激素释放的方法和装置

    公开(公告)号：US07650190B2

    公开(公告)日：2010-01-19

    申请号：US11751813

    申请日：2007-05-22

    申请人： Xiaohong Zhou ,  Thomas J. Mullen ,  Gary W. King ,  Michael R. S. Hill

    发明人： Xiaohong Zhou ,  Thomas J. Mullen ,  Gary W. King ,  Michael R. S. Hill

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36071 ,  A61N1/205 ,  A61N1/36021

    摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.

    摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括但不限于在T7-L2皮层区域内的T7-L2级和相关神经纤维的脊髓。

    Shunt-current reduction techniques for an implantable therapy system
    17.
    发明授权
    Shunt-current reduction techniques for an implantable therapy system 有权
    用于植入式治疗系统的分流电流还原技术

    公开(公告)号：US09192769B2

    公开(公告)日：2015-11-24

    申请号：US12551331

    申请日：2009-08-31

    申请人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Gerald P. Arne ,  Xiaohong Zhou

    发明人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Gerald P. Arne ,  Xiaohong Zhou

    IPC分类号： A61N1/08 ,  A61N1/37 ,  A61N1/36 ,  A61N1/372

    CPC分类号： A61N1/3718 ,  A61N1/08 ,  A61N1/086 ,  A61N1/36114 ,  A61N1/37288

    摘要： Techniques for minimizing interference between the first and second medical devices or between the different therapy modules of a common medical device are described herein. In some examples, a medical device may include shunt-current mitigation circuitry and/or at least one clamping structure that helps minimize or even eliminate shunt-current that feeds into a first therapy module of the medical device via one or more electrodes electrically connected to the first therapy module. The shunt-current may be generated by the delivery of electrical stimulation by a second therapy module. The second therapy module may be enclosed in a common housing with the first therapy module or may be separate, e.g., a part of a separate medical device.

    摘要翻译： 本文描述了用于最小化第一和第二医疗装置之间或在普通医疗装置的不同治疗模块之间的干扰的技术。 在一些示例中，医疗装置可以包括分流电流缓解电路和/或至少一个夹持结构，其有助于最小化或甚至消除通过电连接到医疗装置的一个或多个电极馈入医疗装置的第一治疗模块的分流电流 第一疗法模块。 分流电流可以通过第二治疗模块的电刺激递送来产生。 第二治疗模块可以用第一治疗模块封闭在共同的壳体中，或者可以是分离的，例如单独的医疗装置的一部分。

    METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS
    19.
    发明申请
    METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS 审中-公开
    使用声音监测心脏和呼吸系统状况的方法和装置

    公开(公告)号：US20130060150A1

    公开(公告)日：2013-03-07

    申请号：US13456357

    申请日：2012-04-26

    申请人： Zhendong Song ,  Xiaohong Zhou

    发明人： Zhendong Song ,  Xiaohong Zhou

    IPC分类号： A61B5/0205 ,  A61B7/00 ,  A61B5/08

    CPC分类号： A61B7/003 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/0826 ,  A61B7/00 ,  A61N1/3627 ,  A61N1/36514

    摘要： A medical device system and associated method discriminating conditions that includes a plurality of sensors, a sensing module coupled to the plurality of sensors and configured to acquire signals from the plurality of sensors, and a processor coupled to the sensing module and configured to determine a change in a respiratory related sounds in response to a signal from a sensor of the plurality of sensors, select one or more sensors of the plurality of sensors associated with the determined change, determine a respiratory signature in response to signals from the selected one or more sensors, and determine the respiratory condition in response to the determined respiratory signature.

    摘要翻译： 一种医疗设备系统和相关联的方法来区分包括多个传感器的条件，耦合到多个传感器并被配置为从多个传感器获取信号的感测模块以及耦合到感测模块并被配置为确定变化的处理器 在响应于来自多个传感器的传感器的信号的呼吸相关声音中，选择与所确定的变化相关联的多个传感器中的一个或多个传感器，响应于来自所选择的一个或多个传感器的信号来确定呼吸特征 并且响应于所确定的呼吸标志来确定呼吸状况。

    METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS
    20.
    发明申请
    METHOD AND APPARATUS FOR MONITORING CARDIAC AND RESPIRATORY CONDITIONS USING ACOUSTIC SOUNDS 审中-公开
    使用声音监测心脏和呼吸道条件的方法和装置

    公开(公告)号：US20130060149A1

    公开(公告)日：2013-03-07

    申请号：US13456346

    申请日：2012-04-26

    申请人： Zhendong Song ,  Xiaohong Zhou

    发明人： Zhendong Song ,  Xiaohong Zhou

    IPC分类号： A61B7/00 ,  A61B5/0205

    摘要： A medical device system and associated method discriminate respiratory and cardiac conditions using respiratory sounds. A sensing module acquires a first signal and a second signal, at least the second signal acquired from an acoustic transducer. A processor is configured to receive the first signal and to control the sensing module to acquire the second acoustic signal in response to a change in the first signal. The processor discriminates between a cardiac condition and a respiratory condition as a cause of the change in the first signal in response to the second acoustic signal.

    摘要翻译： 医疗设备系统和相关方法使用呼吸音来辨别呼吸和心脏病状。 感测模块​​至少从声换能器获取的第二信号获取第一信号和第二信号。 处理器被配置为接收第一信号并且响应于第一信号的改变来控制感测模块获取第二声信号。 处理器根据第二声信号，将心脏状况与呼吸状况鉴别为第一信号的变化的原因。