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公开(公告)号：US20060199222A1
公开(公告)日：2006-09-07
申请号：US11215675
申请日：2005-08-30
CPC分类号： C12N15/902 , C12N15/102 , C12N15/90
摘要： The present invention provides methods for building DNA constructs in vitro, transforming such constructs into competent Bacillus strains with good efficiency, and generating populations of mutants. Also provided is a method to assemble DNA constructs in situ.
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公开(公告)号：US20050244395A1
公开(公告)日：2005-11-03
申请号：US11008049
申请日：2004-12-09
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C12N9/00 , C12N9/50 , C12N9/86
摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
摘要翻译： 本发明提供了靶向酶，其比相同的预靶向酶更好地结合靶，在相似条件下与目标酶结合，制备靶向酶的方法，使用靶向酶治疗疾病的方法，以及包含靶向酶的药物组合物。
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13.发明授权Method for generating a library of oligonucleotides comprising a controlled distribution of mutations 有权产生寡核苷酸文库的方法，其包含受控的突变分布公开(公告)号：US06582914B1
公开(公告)日：2003-06-24
申请号：US09699250
申请日：2000-10-26
IPC分类号： C12Q168
CPC分类号： C12N15/1031 , C12N15/102 , C12N15/1027 , C40B40/00
摘要： Methods are disclosed for producing libraries of nucleic acid molecules which libraries are derived from a nucleic acid template. The libraries comprise variant nucleic acids which are produced from a mutagenesis strategy using, e.g., a plurality of defined mutagenic and/or non-mutagenic primers and specific reaction conditions which favor the production of varied combinatorial mutants.
摘要翻译： 公开了用于产生文库来自核酸模板的核酸分子文库的方法。 文库包含使用例如多个确定的诱变和/或非诱变引物和有利于产生不同组合突变体的特异性反应条件的诱变策略产生的变体核酸。
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公开(公告)号：US06436632B1
公开(公告)日：2002-08-20
申请号：US09970578
申请日：2001-10-04
IPC分类号： C12Q100
摘要： A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes.
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公开(公告)号：US08933197B2
公开(公告)日：2015-01-13
申请号：US12228859
申请日：2008-08-15
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明涉及与一种或多种辅助多肽连接的生物活性多肽。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US08673860B2
公开(公告)日：2014-03-18
申请号：US12699761
申请日：2010-02-03
申请人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： A61K38/16
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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17.发明申请公开(公告)号：US20120263703A1
公开(公告)日：2012-10-18
申请号：US13392511
申请日：2010-08-02
申请人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
发明人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子DC凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20120220011A1
公开(公告)日：2012-08-30
申请号：US13396403
申请日：2012-02-14
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
IPC分类号： C07K14/00 , C07K14/52 , C07K14/475 , C07K14/62 , C12N9/78 , C12N9/50 , C12N9/06 , C12N9/16 , C12N9/74 , C12N9/22 , C12N15/11 , C12N15/63 , C07K14/605 , C07K14/745 , C12N1/21 , C07K14/505
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20120178691A1
公开(公告)日：2012-07-12
申请号：US13423031
申请日：2012-03-16
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC分类号： A61K38/37 , C12N15/62 , C12N15/63 , A61P7/04 , C12N1/19 , C12N1/15 , C12N1/21 , C07K19/00 , C12N5/10
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20120094357A1
公开(公告)日：2012-04-19
申请号：US13323291
申请日：2011-12-12
IPC分类号： C12N9/96
CPC分类号： B82Y5/00 , A61K47/6899 , A61K2039/505 , C07K16/30 , C07K2317/622
摘要： The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.
摘要翻译： 本发明涉及TAB分子，针对TAG-72的ADEPT构建体及其在治疗中的应用。
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