公开(公告)号：US20180078875A1

公开(公告)日：2018-03-22

申请号：US15790946

申请日：2017-10-23

Applicant: Waters Technologies Corporation

Inventor： Kurt D. Joudrey ,  Paul Keenan ,  Richard W. Andrews ,  Peyton C. Beals ,  Joshua A. Shreve

IPC: B01D15/10 ,  G01N30/32 ,  B01D15/40 ,  B01D15/16 ,  G01N30/30

CPC classification number: B01D15/10 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/3007 ,  G01N2030/324

Abstract: A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.

公开(公告)号：US09488624B2

公开(公告)日：2016-11-08

申请号：US14737812

申请日：2015-06-12

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/04 ,  G01N30/86 ,  B01D15/42 ,  G01N30/30

CPC classification number: G01N30/04 ,  B01D15/424 ,  G01N30/8672 ,  G01N2030/047 ,  G01N2030/3007

Abstract: Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems and a sample for performing the method. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.

Abstract translation: 描述了在液相色谱（LC）系统和用于执行该方法的样品之间转移色谱方法的方法。 该方法基于两个溶质共洗脱的等离子体停留温度的测定。 该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。 例如，该方法允许为HPLC开发的色谱方法容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。 该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。 导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

公开(公告)号：US20150129494A1

公开(公告)日：2015-05-14

申请号：US14539336

申请日：2014-11-12

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Kurt D. Joudrey ,  Paul Keenan ,  Richard W. Andrews ,  Peyton C. Beals ,  Joshua A. Shreve

IPC: B01D15/10 ,  B01D15/40

CPC classification number: B01D15/10 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/3007 ,  G01N2030/324

Abstract: A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.

Abstract translation: 用于控制流过色谱系统的流体的方法包括确定与色谱系统中第一流体位置处的密度有关的流体参数; 并且响应于所确定的流体参数，修改色谱系统中的第二流体位置的体积流量或压力以产生所选流体的质量流量。

公开(公告)号：US11105778B2

公开(公告)日：2021-08-31

申请号：US16098280

申请日：2017-05-04

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Richard W. Andrews ,  Peyton C. Beals ,  Thomas McDonald ,  Keith Fadgen ,  Jordan Kornfeld ,  Geoff Gerhardt ,  Sylvain Cormier

IPC: G01N30/24 ,  G01N30/06 ,  G01N30/20 ,  G01N30/34 ,  G01N1/38

Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.

公开(公告)号：US20190170706A1

公开(公告)日：2019-06-06

申请号：US16098280

申请日：2017-05-04

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Richard W. Andrews ,  Peyton C. Beals ,  Thomas McDonald ,  Keith Fadgen ,  Jordan Kornfeld ,  Geoff Gerhardt ,  Sylvain Cormier

IPC: G01N30/24 ,  G01N30/06

Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.