公开(公告)号：US10345186B2

公开(公告)日：2019-07-09

申请号：US15681136

申请日：2017-08-18

Applicant: Waters Technologies Corporation

Inventor： Theodore D. Ciolkosz ,  James E. Usowicz ,  Peyton C. Beals ,  Russell Keene

IPC: G01N11/00 ,  G01N30/24 ,  G01N30/32 ,  G01M3/02 ,  B01D15/14 ,  B01D15/16

Abstract: A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible falling components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system.

公开(公告)号：US20160054274A1

公开(公告)日：2016-02-25

申请号：US14824431

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Mark W. Moeller ,  Peyton C. Beals

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.

Abstract translation: 描述了在液相色谱系统中在注射位置稀释样品的方法和系统。 该方法包括将样品装载到第一流体通道中，将流动相的流分离成第一流体通道中的第一流量，以及在第二流体通道中的第二流量，以及将从第一流体通道 以及在注入系统流程的位置处离开第二流体通道的流动相，从而在系统流中产生稀释的样品。 稀释样品的稀释比对第一和第二流量的流量有反应。 有利地，可以通过改变流体通道之一的流量限制来改变流量。 因此，提供适当的流量限制使得用户能够获得期望的稀释比。

公开(公告)号：US11899000B2

公开(公告)日：2024-02-13

申请号：US16011761

申请日：2018-06-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC: G01N30/64 ,  G01N30/86 ,  G01N30/34 ,  G01N30/88 ,  G01N21/53

CPC classification number: G01N30/64 ,  G01N30/34 ,  G01N30/8624 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8675 ,  G01N30/88 ,  G01N21/53 ,  G01N2030/8804

Abstract: A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US11656208B2

公开(公告)日：2023-05-23

申请号：US17206994

申请日：2021-03-19

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/88 ,  G01N30/02

CPC classification number: G01N30/32 ,  G01N30/20 ,  G01N30/22 ,  G01N30/24 ,  G01N30/34 ,  G01N30/8665 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328 ,  G01N2030/347 ,  G01N2030/8804 ,  G01N2030/889 ,  G01N2030/8881

Abstract: A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.

公开(公告)号：US20180364205A1

公开(公告)日：2018-12-20

申请号：US16011761

申请日：2018-06-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC: G01N30/64 ,  G01N30/34 ,  G01N30/86

Abstract: A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US20150276687A1

公开(公告)日：2015-10-01

申请号：US14737812

申请日：2015-06-12

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/04

CPC classification number: G01N30/04 ,  B01D15/424 ,  G01N30/8672 ,  G01N2030/047 ,  G01N2030/3007

Abstract: Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems and a sample for performing the method. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.

Abstract translation: 描述了在液相色谱（LC）系统和用于执行该方法的样品之间转移色谱方法的方法。 该方法基于两个溶质共洗脱的等离子体停留温度的测定。 该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。 例如，该方法允许为HPLC开发的色谱方法容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。 该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。 导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

公开(公告)号：US20130340503A1

公开(公告)日：2013-12-26

申请号：US13973295

申请日：2013-08-22

Applicant: Waters Technologies Corporation

Inventor： Theodore D. Ciolkosz ,  James E. Usowicz ,  Peyton C. Beals ,  Russell Keene

IPC: G01M3/02 ,  G01N11/00

CPC classification number: G01M3/02 ,  B01D15/14 ,  B01D15/163 ,  G01N11/00 ,  G01N30/24 ,  G01N30/32

Abstract: A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system.

Abstract translation: 包括压力监测器和控制装置的装置用于接收表示压力监测器上测量的压力并控制流体系统的可控元件的信号，以监测流体系统的误差状况，优化操作并诊断流体系统 。 通过遵循选择性地启用系统部件的测试协议，控制装置缩小可能出现故障的部件的列表。 将测量的压力与正常压力进行比较允许设备识别错误状况。 确定正在运输的流体的体积并控制流动持续时间优化了流体系统的运行。

公开(公告)号：US10955391B2

公开(公告)日：2021-03-23

申请号：US15559276

申请日：2016-02-17

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/88 ,  G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/02

Abstract: A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.

公开(公告)号：US09823225B2

公开(公告)日：2017-11-21

申请号：US14824431

申请日：2015-08-12

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Mark W. Moeller ,  Peyton C. Beals

IPC: G01N30/20 ,  G01N30/06 ,  G01N30/02 ,  G01N30/24

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: Described are a method and a system for diluting a sample at a location of injection in a liquid chromatography system. The method includes loading a sample into a first fluid channel, separating a flow of a mobile phase into a first flow in the first fluid channel and a second flow in a second fluid channel, and combining the sample that is displaced from the first fluid channel and the mobile phase exiting the second fluid channel at the location of injection into the system flow to thereby generate a diluted sample in the system flow. The dilution ratio of the diluted sample is responsive to the flow rates of the first and second flows. Advantageously, the flow rates can be changed by changing the flow restriction of one of the fluid channels. Thus providing the proper flow restriction enables a user to obtain a desired dilution ratio.

公开(公告)号：US20230083910A1

公开(公告)日：2023-03-16

申请号：US17993392

申请日：2022-11-23

Applicant: Waters Technologies Corporation

Inventor： Peyton C. Beals ,  Sylvain Gilles Cormier ,  Richard Wayne Andrews

IPC: G01N30/34 ,  B01F25/432 ,  B01F33/30

Abstract: Described is a mixer for a chromatography system. The mixer includes an inlet manifold channel, an outlet manifold channel and a plurality of transfer channels. The inlet manifold channel has an inlet at a proximal end of the inlet manifold channel for receiving an inlet flow. The transfer channels are fluidly connected between the inlet and outlet manifold channels. The respective fluid connections are distributed along each of the inlet and outlet manifolds channels. The transfer channels have different volumes. The mixer may be formed of a plurality of layer and the layers may be diffusion bonded to each other.