公开(公告)号：US10551362B2

公开(公告)日：2020-02-04

申请号：US14779274

申请日：2014-03-19

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews

IPC: G01N30/62 ,  G01N30/74 ,  G01N30/86 ,  G01N21/27 ,  G01N21/31 ,  G01N21/59

Abstract: The invention generally provides methods for improving the dynamic range of an absorbance detector and absorbance detectors having improved dynamic range. In an exemplary embodiment, the method includes receiving calibration data for a plurality of samples, the calibration data comprising an absorbance for a concentration of each of the samples, calculating a contribution of stray light to the calibration data, and correcting subsequent data by removing the contribution of stray light.

公开(公告)号：US20130228513A1

公开(公告)日：2013-09-05

申请号：US13748865

申请日：2013-01-24

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Richard W. Andrews

IPC: B01D15/10

CPC classification number: B01D15/10 ,  G01N30/34 ,  G01N30/8668

Abstract: Described is a method of transferring a gradient separation method to a liquid chromatography system. A value of a delivered gradient slope for a gradient separation method performed on a first liquid chromatography system is determined based on a value of a programmed gradient slope for the gradient separation method and a predetermined relationship between delivered gradient slope and programmed gradient slope for the first liquid chromatography system. The gradient separation method is performed on a second liquid chromatography system using a delivered gradient slope having a value equal to the value of the delivered gradient slope determined for the first liquid chromatography system

Abstract translation: 描述了将梯度分离方法转移到液相色谱系统的方法。 基于梯度分离方法的编程梯度斜率的值和第一液相色谱系统的递归梯度斜率和编程梯度斜率之间的预定关系确定在第一液相色谱系统上执行的梯度分离方法的递送梯度斜率的值 液相色谱系统。 梯度分离方法在第二液相色谱系统上进行，使用递送梯度斜率，其值等于为第一液相色谱系统确定的递送梯度斜率的值

公开(公告)号：US11899000B2

公开(公告)日：2024-02-13

申请号：US16011761

申请日：2018-06-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC: G01N30/64 ,  G01N30/86 ,  G01N30/34 ,  G01N30/88 ,  G01N21/53

CPC classification number: G01N30/64 ,  G01N30/34 ,  G01N30/8624 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8675 ,  G01N30/88 ,  G01N21/53 ,  G01N2030/8804

Abstract: A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US11656208B2

公开(公告)日：2023-05-23

申请号：US17206994

申请日：2021-03-19

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/88 ,  G01N30/02

CPC classification number: G01N30/32 ,  G01N30/20 ,  G01N30/22 ,  G01N30/24 ,  G01N30/34 ,  G01N30/8665 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328 ,  G01N2030/347 ,  G01N2030/8804 ,  G01N2030/889 ,  G01N2030/8881

Abstract: A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.

公开(公告)号：US20180364205A1

公开(公告)日：2018-12-20

申请号：US16011761

申请日：2018-06-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC: G01N30/64 ,  G01N30/34 ,  G01N30/86

Abstract: A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US20150276687A1

公开(公告)日：2015-10-01

申请号：US14737812

申请日：2015-06-12

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/04

CPC classification number: G01N30/04 ,  B01D15/424 ,  G01N30/8672 ,  G01N2030/047 ,  G01N2030/3007

Abstract: Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems and a sample for performing the method. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.

Abstract translation: 描述了在液相色谱（LC）系统和用于执行该方法的样品之间转移色谱方法的方法。 该方法基于两个溶质共洗脱的等离子体停留温度的测定。 该方法可以使用具有可重现性和等效结果的不同液相色谱系统进行分离。 例如，该方法允许为HPLC开发的色谱方法容易转移到UPLC系统中，并且为UPLC系统开发的色谱方法更容易转移到HPLC系统。 该方法解决了具有不同设计的列炉的LC系统，其中内部柱温度不相等，尽管柱式炉的操作温度可以被精确地控制为相等的值。 导致不同LC系统的保持行为和分辨率基本相同，从而获得等效的分离结果。

公开(公告)号：US20150125963A1

公开(公告)日：2015-05-07

申请号：US14406291

申请日：2013-06-26

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews

IPC: B01L3/00

CPC classification number: B01L3/545 ,  B01L3/5055 ,  B01L2200/028 ,  B01L2300/022 ,  B01L2300/0816 ,  B01L2300/126 ,  Y10T436/25

Abstract: Techniques for use with dried sample portions include a device having sample areas, identification areas and detachable portions. Each sample area includes one of the dried sample portions of the sample. Each identification area includes information stored therein which identifies the sample from which the dried sample portions stored on the sample areas of the device are obtained. Each detachable portion includes one of the sample areas and includes one of the identification areas. Also described is a method for processing dried sample portions of a sample. A card is received that includes a plurality of detachable portions. Each detachable portion includes a sample area with a dried sample portion and an identification area including information that identifies the sample. A first detachable portion is detached to process a dried sample portion included in the first detachable portion.

Abstract translation: 用于干燥样品部分的技术包括具有样品区域，识别区域和可拆卸部分的装置。 每个样品区域包括样品的干燥样品部分之一。 每个识别区域包括存储在其中的信息，其识别从其获得装置的样品区域上存储的干燥样品部分的样品。 每个可拆卸部分包括一个样本区域，并且包括识别区域之一。 还描述了用于处理样品的干燥样品部分的方法。 接收包括多个可拆卸部分的卡。 每个可拆卸部分包括具有干燥样品部分的样品区域和包括识别样品的信息的识别区域。 拆卸第一可拆卸部分以处理包括在第一可拆卸部分中的干燥样品部分。

公开(公告)号：US10955391B2

公开(公告)日：2021-03-23

申请号：US15559276

申请日：2016-02-17

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/88 ,  G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/02

Abstract: A chromatography system has an associated system volume and a sample dispersion volume. The chromatography system comprises a pump pumping a flow of gradient, a sample manager for introducing a sample into the flow of gradient, and a valve manager fluidically coupled to the pump and to the sample manager. The valve manager includes at least one valve. A first valve of the at least one valve has a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the first valve. The first valve has at least two different, automatically selectable positions. A first position of the at least two different automatically selectable positions operating to change one of the system and sample dispersion volumes of the chromatography system when the first valve is automatically switched into the first position.

公开(公告)号：US20150076068A1

公开(公告)日：2015-03-19

申请号：US14464979

申请日：2014-08-21

Applicant: Waters Technologies Corporation

Inventor： Richard W. Andrews ,  Peyton Beals ,  Sylvain Cormier

IPC: B01D15/16 ,  B01D15/18 ,  B01D15/42

CPC classification number: B01D15/161 ,  B01D15/1871 ,  B01D15/424

Abstract: Described are methods in which the retention times of a chromatographic column are adjusted through the control of the temperature of a mobile phase at the inlet to the chromatographic column. The temperature of the mobile phase at the inlet is different from the temperature of the chromatographic column. Adjustment of the temperature of the mobile phase at the inlet can be used as part of a method to transfer a chromatographic method from one liquid chromatography system to another liquid chromatography system. The method can alternatively be adapted for trapping a sample at the head of a chromatographic column to reduce the amount of band broadening of the sample from the sample injector of a liquid chromatography system. A gradient elution can then be performed to cause the concentrated volume of the analyte in the sample to elute in a tight band, resulting in improved measurement sensitivity.

Abstract translation: 描述了通过控制色谱柱入口处的流动相的温度来调节色谱柱的保留时间的方法。 入口处流动相的温度不同于色谱柱的温度。 入口处流动相温度的调节可用作将色谱法从一个液相色谱系统转移到另一个液相色谱系统的方法的一部分。 该方法可替代地适用于在色谱柱的头部捕获样品以减少来自液相色谱系统的样品注射器的样品的带宽增加量。 然后可以进行梯度洗脱，使得样品中分析物的浓缩体系在紧密带中洗脱，从而提高了测量灵敏度。

公开(公告)号：US20210208114A1

公开(公告)日：2021-07-08

申请号：US17206994

申请日：2021-03-19

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/88

Abstract: A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.