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    Isolation and characterization of the precursor virus of human SARS virus: SARS-associated corona virus-like virus
    16.
    发明授权
    Isolation and characterization of the precursor virus of human SARS virus: SARS-associated corona virus-like virus 有权
    人类SARS病毒前体病毒的分离和表征：SARS相关的电晕病毒样病毒

    公开(公告)号：US07361747B2

    公开(公告)日：2008-04-22

    申请号：US10852357

    申请日：2004-05-24

    申请人： Yi Guan ,  Bo-Jiang Zheng

    发明人： Yi Guan ,  Bo-Jiang Zheng

    IPC分类号： C07H21/02 ,  C07H19/00

    CPC分类号： A61K39/215 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

    摘要： The present invention relates to isolation and characterization of a class of isolated novel viruses which is the precursor of the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The precursor virus which is a SARS coronavirus-like virus (“SCoV-like virus”) is identified to be morphologically and phylogenetically similar to hSARS virus. The present invention relates to a nucleotide sequence comprising the genomic sequence of the SCoV-like virus. The invention further relates to nucleotide sequences comprising a portion of the genomic sequence of the SCoV-like virus. The invention also relates to the deduced amino acid sequences of the SCoV-like virus. The invention further relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and therapeutic methods. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies directed against polypeptides encoded by the nucleotide sequences. Furthermore, the invention relates to vaccine preparations comprising the SCoV-like virus, including recombinant and chimeric forms of said virus.

    摘要翻译： 本发明涉及分离和表征一类分离的新型病毒，其是引起人类严重急性呼吸综合征（SARS）的病毒的前体（“hSARS病毒”）。 鉴定为SARS冠状病毒样病毒（“SCoV样病毒”）的前体病毒在形态和系统发育上与hSARS病毒相似。 本发明涉及包含SCoV样病毒的基因组序列的核苷酸序列。 本发明还涉及包含SCoV样病毒的基因组序列的一部分的核苷酸序列。 本发明还涉及SCoV样病毒的推导的氨基酸序列。 本发明还涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法和治疗方法中的用途。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒和针对由核苷酸序列编码的多肽的抗体。 此外，本发明涉及包含SCoV样病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。

    ISOLATION AND CHARACTERIZATION OF THE PRECURSOR VIRUS OF HUMAN SARS VIRUS: SARS-ASSOCIATED CORONA VIRUS-LIKE VIRUS
    17.
    发明申请
    ISOLATION AND CHARACTERIZATION OF THE PRECURSOR VIRUS OF HUMAN SARS VIRUS: SARS-ASSOCIATED CORONA VIRUS-LIKE VIRUS 有权
    人类SARS病毒前列腺病毒的分离和特征：SARS相关的类癌病毒样病毒

    公开(公告)号：US20080069839A1

    公开(公告)日：2008-03-20

    申请号：US10852357

    申请日：2004-05-24

    申请人： Yi Guan ,  Bo-Jiang Zheng

    发明人： Yi Guan ,  Bo-Jiang Zheng

    IPC分类号： A61K39/215 ,  C07H21/04 ,  C12N7/00 ,  C07K14/165 ,  C07K16/10

    CPC分类号： A61K39/215 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

    摘要： The present invention relates to isolation and characterization of a class of isolated novel viruses which is the precursor of the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The precursor virus which is a SARS coronavirus-like virus (“SCoV-like virus”) is identified to be morphologically and phylogenetically similar to hSARS virus. The present invention relates to a nucleotide sequence comprising the genomic sequence of the SCoV-like virus. The invention further relates to nucleotide sequences comprising a portion of the genomic sequence of the SCoV-like virus. The invention also relates to the deduced amino acid sequences of the SCoV-like virus. The invention further relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and therapeutic methods. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies directed against polypeptides encoded by the nucleotide sequences. Furthermore, the invention relates to vaccine preparations comprising the SCoV-like virus, including recombinant and chimeric forms of said virus.

    摘要翻译： 本发明涉及分离和表征一类分离的新型病毒，其是引起人类严重急性呼吸综合征（SARS）的病毒的前体（“hSARS病毒”）。 鉴定为SARS冠状病毒样病毒（“SCoV样病毒”）的前体病毒在形态和系统发育上与hSARS病毒相似。 本发明涉及包含SCoV样病毒的基因组序列的核苷酸序列。 本发明还涉及包含SCoV样病毒的基因组序列的一部分的核苷酸序列。 本发明还涉及SCoV样病毒的推导的氨基酸序列。 本发明还涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法和治疗方法中的用途。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒和针对由核苷酸序列编码的多肽的抗体。 此外，本发明涉及包含SCoV样病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。

    Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof
    18.
    发明申请
    Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof 审中-公开
    用于治疗禽流感的中药组合物，制备方法及其应用

    公开(公告)号：US20070172531A1

    公开(公告)日：2007-07-26

    申请号：US11655563

    申请日：2007-01-19

    申请人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    发明人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    IPC分类号： A61K36/537 ,  A61K36/282 ,  A61K36/48 ,  A61K36/28

    CPC分类号： A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/489 ,  A61K36/78 ,  A61K36/896 ,  A61K2300/00

    摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its activated ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.l wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.

    摘要翻译： 提供了一种预防和治疗禽流感的中药组合物。 其活性成分由以下组成：her e 21.4重量％ ％，金银花17.9重量％ ％，丹参14.3重量％ ％，雄蕨根茎10.7wt。 ％，radix et rhizoma sophorae tonkinensis 7.1 wt。 ％，当归丹参7.1重量％ ％，百日草 ％，峨眉草7.2重量％ ％，和根瘤菌7.2重量％ ％。 这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途 本发明还提供了预防或治疗禽流感的药物和保健食品的制备。 这种中药组合物可以有效预防和治疗禽流感。 这是一种更安全，更容易获得和便宜的抗禽流感药物。

    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    19.
    发明申请
    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的高通量诊断测定

    公开(公告)号：US20050181357A1

    公开(公告)日：2005-08-18

    申请号：US10807807

    申请日：2004-03-24

    申请人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls ,  Frederick Leung

    发明人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls ,  Frederick Leung

    IPC分类号： A61P11/00 ,  A61P31/14 ,  C12N15/50 ,  C12Q1/68 ,  C12Q1/70 ,  C07H21/02 ,  C07K14/165 ,  C07K16/10

    CPC分类号： C12Q1/701 ,  C12Q1/6844 ,  Y02A50/451

    摘要： The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.

    摘要翻译： 本发明涉及用于引起人类严重急性呼吸综合征（SARS）的病毒（“hSARS病毒”）的高通量诊断测定法。 特别地，本发明涉及SARS相关冠状病毒（SARS-CoV）的高通量逆转录PCR诊断试验。 本试验是一种快速，可靠的测定法，可用于诊断和监测SARS的扩散，并且基于hSARS病毒的N（核衣壳）基因的核苷酸序列。 本方法消除假阴性结果并提供增加的检测灵敏度。 本发明还公开了hSARS病毒的S（尖峰）基因。 本发明还涉及hSARS病毒的N-基因和S-基因产物的推断氨基酸序列以及在诊断方法中使用N-基因和S-基因产物。 本发明还包括诊断测定和试剂盒，其包含针对N-基因或S-基因产物产生的抗体。