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    Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof
    1.
    发明申请
    Chinese traditional medicine composition for treatment of avian influenza, method for preparation, and application thereof 审中-公开
    用于治疗禽流感的中药组合物，制备方法及其应用

    公开(公告)号：US20070172531A1

    公开(公告)日：2007-07-26

    申请号：US11655563

    申请日：2007-01-19

    申请人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    发明人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    IPC分类号： A61K36/537 ,  A61K36/282 ,  A61K36/48 ,  A61K36/28

    CPC分类号： A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/489 ,  A61K36/78 ,  A61K36/896 ,  A61K2300/00

    摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its activated ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.l wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.

    摘要翻译： 提供了一种预防和治疗禽流感的中药组合物。 其活性成分由以下组成：her e 21.4重量％ ％，金银花17.9重量％ ％，丹参14.3重量％ ％，雄蕨根茎10.7wt。 ％，radix et rhizoma sophorae tonkinensis 7.1 wt。 ％，当归丹参7.1重量％ ％，百日草 ％，峨眉草7.2重量％ ％，和根瘤菌7.2重量％ ％。 这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途 本发明还提供了预防或治疗禽流感的药物和保健食品的制备。 这种中药组合物可以有效预防和治疗禽流感。 这是一种更安全，更容易获得和便宜的抗禽流感药物。

    Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof
    2.
    发明授权
    Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
    用于治疗禽流感的中药组合物，其制备方法及应用

    公开(公告)号：US09265805B2

    公开(公告)日：2016-02-23

    申请号：US12030997

    申请日：2008-02-14

    申请人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    发明人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    IPC分类号： A61K36/489 ,  A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/78 ,  A61K36/896

    CPC分类号： A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/489 ,  A61K36/78 ,  A61K36/896 ,  A61K2300/00

    摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.

    摘要翻译： 提供了一种预防和治疗禽流感的中药组合物。 其活性成分包括：her e 21.4重量％ ％，金银花17.9重量％ ％，丹参14.3重量％ ％，雄蕨根茎10.7wt。 ％，radix et rhizoma sophorae tonkinensis 7.1 wt。 ％，当归丹参7.1重量％ ％，百草枯7.1重量％ ％，峨眉草7.2重量％ ％，和根瘤菌7.2重量％ ％。 这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途 本发明还提供了预防或治疗禽流感的药物和保健食品的制备。 这种中药组合物可以有效预防和治疗禽流感。 这是一种更安全，更容易获得和便宜的抗禽流感药物。

    Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof
    3.
    发明授权
    Chinese traditional medicine composition for treatment of avian influenza, method for preparation and application thereof 有权
    用于治疗禽流感的中药组合物，其制备方法及应用

    公开(公告)号：US08795742B2

    公开(公告)日：2014-08-05

    申请号：US12030977

    申请日：2008-02-14

    申请人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    发明人： Desheng Tao ,  Yongqing Zeng ,  Hui Cao ,  Yi Guan

    IPC分类号： A61K36/00 ,  A61K36/355 ,  A61K36/489 ,  A61K36/232

    CPC分类号： A61K36/11 ,  A61K36/232 ,  A61K36/282 ,  A61K36/315 ,  A61K36/355 ,  A61K36/489 ,  A61K36/78 ,  A61K36/896 ,  A61K2300/00

    摘要： A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its active ingredients are consisted of: herba houttuyniae 21.4 wt. %, Caulis lonicerae japonicae 17.9 wt. %, radix isatidis 14.3 wt. %, male fern rhizome 10.7 wt. %, radix et rhizoma sophorae tonkinensis 7.1 wt. %, radix angelicae dahuricae 7.1 wt. %, rhizoma paridis 7.1 wt. %, herba artemisiae annuae 7.2 wt. %, and rhizoma iridis tectoris 7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.

    摘要翻译： 提供了一种预防和治疗禽流感的中药组合物。 其活性成分包括：her e 21.4重量％ ％，金银花17.9重量％ ％，丹参14.3重量％ ％，雄蕨根茎10.7wt。 ％，radix et rhizoma sophorae tonkinensis 7.1 wt。 ％，当归丹参7.1重量％ ％，百草枯7.1重量％ ％，峨眉草7.2重量％ ％，和根瘤菌7.2重量％ ％。 这种中药组合物可以制成任何常规药物类型，例如口服溶液，片剂，胶囊，丸剂和注射液等。这种中药组合物的改良制剂方法以及其用途 本发明还提供了预防或治疗禽流感的药物和保健食品的制备。 这种中药组合物可以有效预防和治疗禽流感。 这是一种更安全，更容易获得和便宜的抗禽流感药物。

    Human virus causing respiratory tract infection and uses thereof
    6.
    发明授权
    Human virus causing respiratory tract infection and uses thereof 有权
    引起呼吸道感染的人类病毒及其用途

    公开(公告)号：US07553944B2

    公开(公告)日：2009-06-30

    申请号：US10895064

    申请日：2004-07-21

    申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    IPC分类号： C07H21/02 ,  C12N15/00 ,  A61K39/00 ,  A61K39/12

    CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

    摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

    摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    8.
    发明授权
    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的诊断测定

    公开(公告)号：US07267942B2

    公开(公告)日：2007-09-11

    申请号：US10808187

    申请日：2004-03-24

    申请人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls

    发明人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls

    IPC分类号： C12Q1/70 ,  C12N15/50

    CPC分类号： C12Q1/701 ,  C07H21/04 ,  C12Q1/6844

    摘要： The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.

    摘要翻译： 本发明涉及在人类中引起严重急性呼吸综合征（SARS）的病毒的诊断测定法（“hSARS病毒”）。 特别地，本发明涉及使用逆转录和聚合酶链反应检测hSARS病毒的实时定量PCR测定。 具体地，定量测定是使用基于hSARS病毒基因组构建的引物和探针的TaqMan测定法。 本发明还涉及包含用于检测hSARS病毒的核酸分子的诊断试剂盒。

    System and methods for document retrieval using natural language-based queries
    10.
    发明授权
    System and methods for document retrieval using natural language-based queries 失效
    使用自然语言查询的文档检索系统和方法

    公开(公告)号：US06687689B1

    公开(公告)日：2004-02-03

    申请号：US09613849

    申请日：2000-07-11

    申请人： Pascale Fung ,  Chi Shun Cheung ,  Yi Guan ,  Yongsheng Yang

    发明人： Pascale Fung ,  Chi Shun Cheung ,  Yi Guan ,  Yongsheng Yang

    IPC分类号： G06F1730

    CPC分类号： G06F17/30672 ,  Y10S707/99933 ,  Y10S707/99936

    摘要： A system and associated methods identify documents relevant to an inputted natural-language user query. One associate method includes: selecting a set of keywords from the user query; determining at least one word, not necessarily found in the user query, that is semantically similar to a keyword of the set of keywords; using the set of keywords and the at least one word to determining a subset of word sets from a database of pre-stored word sets, wherein the pre-stored word sets are each pre-associated with at least one document; determining a plurality of word sets, from the subset of word sets, that is most semantically similar to the user query; and identifying documents that have been pre-associated with the plurality of word sets as being relevant to the natural-language user query.

    摘要翻译： 系统和相关方法识别与输入的自然语言用户查询相关的文档。 一个关联方法包括：从用户查询中选择一组关键字; 确定语义上类似于该组关键字的关键词的在用户查询中不一定找到的至少一个单词; 使用所述一组关键字和所述至少一个单词来从预先存储的单词集的数据库中确定单词组的子集，其中所述预先存储的单词集每个都与至少一个文档预先关联; 从所述词集的子集中确定在语义上类似于所述用户查询的多个单词集合; 以及将已经与所述多个单词集预先相关联的文档识别为与所述自然语言用户查询相关。