公开(公告)号：US09535057B2

公开(公告)日：2017-01-03

申请号：US12224577

申请日：2007-01-08

Applicant: Shuk Han Cheng ,  Po Kwok Chan

Inventor： Shuk Han Cheng ,  Po Kwok Chan

IPC: G01N33/50

CPC classification number: G01N33/5088 ,  G01N33/5014 ,  G01N2333/4603 ,  G01N2800/326

Abstract: This invention relates to a method of screening agents for cardiotoxicity based on the observations of the alteration of heart rate and heart rhythm, using teleost embryos and larvae. This invention also relates to a method for identification of gene(s) related to cardiac functions in teleost.

Abstract translation: 本发明涉及一种基于心率和心律的改变观察使用硬骨鱼胚胎和幼虫的心脏毒性筛选剂的方法。 本发明还涉及用于鉴定与硬骨肉瘤中的心脏功能有关的基因的方法。

公开(公告)号：US20120005638A1

公开(公告)日：2012-01-05

申请号：US13167237

申请日：2011-06-23

Applicant: Terence Wai-kwok Chan

Inventor： Terence Wai-kwok Chan

IPC: G06F17/50

CPC classification number: G06F17/5031 ,  G06F17/505 ,  G06F2217/84

Abstract: Techniques for performing race logic synthesis on an integrated circuit (IC) are described herein. According to one aspect of the invention, HDL (hardware description language) and/or ESL (electronic system level) design source files of an IC design are compiled into a common design database. Race logic analysis is performed on the IC design, either by a third-party tool or by the same EDA (electronic design automation) tool that also performing race logic synthesis, if the latter has built-in race logic audit functions. Based on the race logic audit results, race logic synthesis is performed on the common design database, and getting rid of all identified race logic in the IC design. This renders the EDA tool can perform concurrent analysis of the IC design, via the race-free common design database, using multi-CPU/core computers and the results will be the same as if the EDA tool had performed serial analysis of the IC design using a single-CPU/core computer. Another aspect of the invention is outputting the re-synthesized logic in the common design database to new HDL/ESL source files. User may use these revised source files to analyze the IC design using other third-party EDA design/verification tools.

Abstract translation: 本文描述了用于在集成电路（IC）上执行比赛逻辑合成的技术。 根据本发明的一个方面，将IC设计的HDL（硬件描述语言）和/或ESL（电子系统级）设计源文件编译成公共设计数据库。 竞赛逻辑分析是通过第三方工具或通过同样的EDA（电子设计自动化）工具进行的，该工具也执行竞赛逻辑综合，如果后者具有内置的比赛逻辑审计功能。 根据比赛逻辑审核结果，在通用设计数据库上进行比赛逻辑综合，并摆脱IC设计中的所有竞赛逻辑。 这使得EDA工具可以通过使用多CPU /核心计算机的无竞争通用设计数据库进行IC设计的并发分析，结果将与EDA工具对IC设计进行串行分析相同 使用单CPU /核心计算机。 本发明的另一方面是将公共设计数据库中的再合成逻辑输出到新的HDL / ESL源文件。 用户可以使用这些修改后的源文件来分析使用其他第三方EDA设计/验证工具的IC设计。

公开(公告)号：US20070299188A1

公开(公告)日：2007-12-27

申请号：US11766423

申请日：2007-06-21

Applicant: Kwok Chan ,  Erik Hagberg ,  Tara Mullen ,  Roy Odle ,  James White ,  Norimitsu Yamaguchi

Inventor： Kwok Chan ,  Erik Hagberg ,  Tara Mullen ,  Roy Odle ,  James White ,  Norimitsu Yamaguchi

IPC: C08K9/04 ,  C08K5/50

CPC classification number: C08J3/201 ,  B82Y30/00 ,  C01B33/44 ,  C08J5/005 ,  C08K3/346 ,  C08K5/50 ,  C08K9/04

Abstract: This invention relates to organic salt compositions useful in the preparation of organoclay compositions, polymer-organoclay composite compositions, and methods for the preparation of polymer nanocomposites. In one embodiment, the present invention provides a method of making a polymer-organoclay composite composition, said method comprising melt mixing a quaternary organoclay composition comprising alternating inorganic silicate layers and organic layers, said organic layers comprising a quaternary organic cation with a polymeric resin comprising at least one polymer selected from the group consisting of polyamides, polyesters, polyarylene sulfides, polyarylene ethers, polyether sulfones, polyether ketones, polyether ether ketones, polyphenylenes, and polycarbonates, said polymeric resin being substantially free of polyetherimides; said melt mixing being carried out at a temperature in a range between about 300° C. and about 450° C. to provide a polymer-organoclay composite composition, said polymer-organoclay composite composition being characterized by a percent exfoliation of at least 10 percent.

Abstract translation: 本发明涉及可用于制备有机粘土组合物，聚合物 - 有机粘土复合材料组合物和制备聚合物纳米复合材料的方法的有机盐组合物。 在一个实施方案中，本发明提供了制备聚合物 - 有机粘土复合材料组合物的方法，所述方法包括熔融混合包含交替的无机硅酸盐层和有机层的季有机粘土组合物，所述有机层包含季铵有机阳离子与聚合树脂， 选自聚酰胺，聚酯，聚亚芳基硫醚，聚亚芳基醚，聚醚砜，聚醚酮，聚醚醚酮，聚苯基和聚碳酸酯的至少一种聚合物，所述聚合物树脂基本上不含聚醚酰亚胺; 所述熔体混合在约300℃至约450℃之间的温度下进行，以提供聚合物 - 有机粘土复合材料组合物，所述聚合物 - 有机粘土复合组合物的特征在于至少10％的剥离百分比 。

公开(公告)号：US20060034853A1

公开(公告)日：2006-02-16

申请号：US11129741

申请日：2005-05-16

Applicant: Kwok Yuen ,  Chiu Yat Woo ,  Kar Pui Lau ,  Kwok Chan

Inventor： Kwok Yuen ,  Chiu Yat Woo ,  Kar Pui Lau ,  Kwok Chan

IPC: A61K39/42 ,  C07H21/04 ,  C12P21/06 ,  C07K14/005

CPC classification number: C12Q1/701 ,  A61K39/12 ,  A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention provides the complete genomic sequence of a novel human coronavirus, coined as human coronavirus-HKU1 (“HCoV-HKU1”), isolated in Hong Kong. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. Futher study on nasopharyngeal aspirates from patients with community-acquired pnbeumonia has revealed that there are two genotypes, genotype A and genotype B, for this virus. In addition to the genomic sequences of these two genotypes, the invention provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by HCoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the HCoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1.

Abstract translation: 本发明提供了在香港分离的作为人冠状病毒HKU1（“HCoV-HKU1”）的新型人冠状病毒的完整基因组序列。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 对社区获得性pnbeumonia患者的鼻咽抽吸物的进一步研究表明，该病毒有两种基因型，A型和B型基因型。 除了这两种基因型的基因组序列外，本发明提供了CoV-HKU1完整基因组的推导的氨基酸序列。 HCoV-HKU1的核苷酸序列和推定的氨基酸序列可用于预防，诊断和/或治疗HCoV-HKU1的感染。 此外，本发明基于HCoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及HCoV-HKU1的亚基的免疫原性和疫苗制剂。

公开(公告)号：US20050047340A1

公开(公告)日：2005-03-03

申请号：US10799704

申请日：2004-03-15

Applicant: Jozef Babiarz ,  Kwok Chan

Inventor： Jozef Babiarz ,  Kwok Chan

IPC: H04L12/24 ,  H04L12/26 ,  H04L12/56 ,  H04L29/06

CPC classification number: H04L47/115 ,  H04L29/06027 ,  H04L43/00 ,  H04L43/0876 ,  H04L43/0888 ,  H04L43/10 ,  H04L43/16 ,  H04L47/12 ,  H04L47/15 ,  H04L47/18 ,  H04L47/2408 ,  H04L47/2416 ,  H04L47/2441 ,  H04L47/26 ,  H04L47/29 ,  H04L47/31 ,  H04L47/70 ,  H04L47/765 ,  H04L47/801 ,  H04L47/821 ,  H04L47/822 ,  H04L65/1066 ,  H04L65/80

Abstract: A technique for end-to-end admission control of real-time packet flows is disclosed. In one particular exemplary embodiment, the technique may be realized as a method for end-to-end admission control of real-time packet flows in a network having a plurality of network elements. The method may comprise transmitting at least one probe packet from a first network element to a second network element via a network path, determining, at at least one intermediate network element on the network path, at least one flow rate associated with a plurality of packets, marking at least one predetermined bit in the at least one probe packet if the at least one flow rate is greater than a predetermined rate, and controlling an admission of additional packets into the network based at least in part on the marking of the at least one predetermined bit in the at least one probe packet.

Abstract translation: 公开了一种用于实时数据包流的端对端许可控制的技术。 在一个特定示例性实施例中，该技术可以被实现为用于具有多个网络元件的网络中的实时分组流的端到端准入控制的方法。 该方法可以包括经由网络路径将至少一个探测分组从第一网络元件发送到第二网络元件，在网络路径上的至少一个中间网络元件处确定与多个分组相关联的至少一个流量 如果所述至少一个流速大于预定速率，则在所述至少一个探测分组中标记至少一个预定比特，并且至少部分地至少部分地基于所述至少一个所述标记的标记来控制附加分组进入所述网络 所述至少一个探测分组中的一个预定位。

公开(公告)号：US20050011023A1

公开(公告)日：2005-01-20

申请号：US10622062

申请日：2003-07-17

Applicant: Kwok Chan

Inventor： Kwok Chan

IPC: A61C17/34 ,  A61C17/22

CPC classification number: A61C17/3472 ,  A61C17/3436 ,  A61C17/3463

Abstract: A brushing attachment for an electric toothbrush includes an elongate neck, a head at an end of the neck, a tuft block located at the head and having bristles parallel to an axis extending in a direction substantially normal to the neck. The tuft block is mounted to the head so as to be movable linearly along the axis and pivotally about the axis. There is a recess in the tuft block facing toward the neck. A driveshaft extends through the neck and has and angularly offset arm received within the recess to effect movement of the tuft block.

Abstract translation: 用于电动牙刷的刷牙附件包括细长的颈部，颈部的头部的头部，位于头部的刷毛簇，并且具有平行于基本上垂直于颈部的方向延伸的轴线的刷毛。 刷毛束块被安装到头部，以便沿轴线线性移动并围绕轴线枢转。 刷毛簇上有一个朝向颈部的凹槽。 驱动轴延伸穿过颈部并且具有并且成角度地抵靠容纳在凹部内的臂以实现刷毛簇的移动。

公开(公告)号：US09026961B2

公开(公告)日：2015-05-05

申请号：US13866815

申请日：2013-04-19

Applicant: Terence Wai-Kwok Chan

Inventor： Terence Wai-Kwok Chan

IPC: G06F17/50

CPC classification number: G06F17/505

Abstract: Techniques for performing race logic synthesis on an integrated circuit (IC) are described herein. According to one aspect of the invention, ESL (electronic system level) and any HDL (hardware description language) design source files of an IC design are compiled into a design database. Race logic analysis is performed on the IC design to detect race logic, including race logic for IPC (inter-process communication) and IPS (inter-process synchronization) objects in the IC design, by a third-party tool and/or by the same host EDA (electronic design automation) tool that will be performing race logic synthesis on the IC design, if the latter has built-in race logic audit functions. Based on the race logic audit results, race logic synthesis is performed on the design database, and getting rid of all identified race logic in the IC design, including IPC- and IPS-related race logic. This renders the EDA tool can perform concurrent analysis of the IC design, via the race-free IC design database, using multi-CPU/core computers and the results will be the same as if the EDA tool had performed serial analysis of the IC design using a single-CPU/core computer. Another aspect of the invention is outputting the re-synthesized logic in the design database to new ESL/HDL source files. User may use these revised source files to analyze the IC design using any other third-party EDA tools.

Abstract translation: 本文描述了用于在集成电路（IC）上执行比赛逻辑合成的技术。 根据本发明的一个方面，将IC设计的ESL（电子系统级）和任何HDL（硬件描述语言）设计源文件编译成设计数据库。 在IC设计上进行比赛逻辑分析，以检测比赛逻辑，包括IC设计中的IPC（进程间通信）和IPS（进程间同步）对象的比赛逻辑，第三方工具和/或 相同的主机EDA（电子设计自动化）工具，将在IC设计上进行竞赛逻辑综合，如果后者具有内置的比赛逻辑审计功能。 根据比赛逻辑审计结果，在设计数据库上进行竞赛逻辑综合，并摆脱IC设计中所有识别的赛车逻辑，包括IPC和IPS相关的比赛逻辑。 这使得EDA工具可以通过使用多CPU /核心计算机的无竞争的IC设计数据库对IC设计进行并发分析，结果将与EDA工具对IC设计进行串行分析相同 使用单CPU /核心计算机。 本发明的另一方面是将设计数据库中的再合成逻辑输出到新的ESL / HDL源文件。 用户可以使用这些修改后的源文件来分析使用任何其他第三方EDA工具的IC设计。

公开(公告)号：US20090232742A1

公开(公告)日：2009-09-17

申请号：US12302732

申请日：2007-01-08

Applicant: Shuk Han Cheng ,  Po Kwok Chan

Inventor： Shuk Han Cheng ,  Po Kwok Chan

IPC: A61B5/00 ,  C12Q1/02

CPC classification number: G01N33/5014 ,  G01N33/5088 ,  G01N2333/4603 ,  G01N2333/515

Abstract: This invention relates to a method of 3-tier system for screening compounds, herb extract or extract of herb combination in formula with angiogenic-modulating activities using transparent teleost embryos as model.

Abstract translation: 本发明涉及使用透明硬骨鱼胚胎作为模型，筛选化合物，草药提取物或草药组合提取物与血管生成调节活性的3层体系的方法。

公开(公告)号：US20090232739A1

公开(公告)日：2009-09-17

申请号：US12224577

申请日：2007-01-08

Applicant: Shuk Han Cheng ,  Po Kwok Chan

Inventor： Shuk Han Cheng ,  Po Kwok Chan

IPC: A61K49/00

CPC classification number: G01N33/5088 ,  G01N33/5014 ,  G01N2333/4603 ,  G01N2800/326

Abstract: This invention relates to a method of screening agents for cardiotoxicity based on the observations of the alteration of heart rate and heart rhythm, using teleost embryos and larvae. This invention also relates to a method for identification of gene(s) related to cardiac functions in teleost.

Abstract translation: 本发明涉及一种基于心率和心律的改变观察使用硬骨鱼胚胎和幼虫的心脏毒性筛选剂的方法。 本发明还涉及用于鉴定与硬骨肉瘤中的心脏功能有关的基因的方法。

公开(公告)号：US07334203B2

公开(公告)日：2008-02-19

申请号：US11162353

申请日：2005-09-07

Applicant: Terence Wai-kwok Chan

Inventor： Terence Wai-kwok Chan

IPC: G06F17/50

CPC classification number: G01R31/318314 ,  G06F17/5031 ,  G06F17/504

Abstract: Techniques for performing static and dynamic race logic analysis on an integrated circuit (IC) are described herein. According to one aspect of the invention, HDL (hardware description language) design source files of an IC design are compiled into a common design database, including recording full timing information of the IC design. A static race logic analysis is performed on the common design database to reveal all possible race logic in the IC design. A dynamic race logic analysis could also be performed on the common design database to reveal times and circuit locations where the race logic would occur when a physical IC chip for the IC design is implemented. A race logic analysis report is generated for the static and/or dynamic race logic analysis, where the race logic analysis report is used to eliminate race logic errors in IC designs, so as to render highest quality IC products that will not exhibit intermittent random failures in field operations.

Abstract translation: 本文描述了用于在集成电路（IC）上执行静态和动态比赛逻辑分析的技术。 根据本发明的一个方面，将IC设计的HDL（硬件描述语言）设计源文件编译成公共设计数据库，包括记录IC设计的完整定时信息。 在通用设计数据库上进行静态比赛逻辑分析，以揭示IC设计中的所有可能的赛车逻辑。 还可以在通用设计数据库上进行动态竞争逻辑分析，以揭示实施IC设计的物理IC芯片时竞赛逻辑将发生的时间和电路位置。 为静态和/或动态比赛逻辑分析生成比赛逻辑分析报告，其中使用比赛逻辑分析报告消除IC设计中的竞赛逻辑错误，以便呈现不会出现间歇性随机故障的最高质量的IC产品 在野外作业。