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    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    1.
    发明申请
    High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的高通量诊断测定

    公开(公告)号：US20050181357A1

    公开(公告)日：2005-08-18

    申请号：US10807807

    申请日：2004-03-24

    申请人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls ,  Frederick Leung

    发明人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls ,  Frederick Leung

    IPC分类号： A61P11/00 ,  A61P31/14 ,  C12N15/50 ,  C12Q1/68 ,  C12Q1/70 ,  C07H21/02 ,  C07K14/165 ,  C07K16/10

    CPC分类号： C12Q1/701 ,  C12Q1/6844 ,  Y02A50/451

    摘要： The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.

    摘要翻译： 本发明涉及用于引起人类严重急性呼吸综合征（SARS）的病毒（“hSARS病毒”）的高通量诊断测定法。 特别地，本发明涉及SARS相关冠状病毒（SARS-CoV）的高通量逆转录PCR诊断试验。 本试验是一种快速，可靠的测定法，可用于诊断和监测SARS的扩散，并且基于hSARS病毒的N（核衣壳）基因的核苷酸序列。 本方法消除假阴性结果并提供增加的检测灵敏度。 本发明还公开了hSARS病毒的S（尖峰）基因。 本发明还涉及hSARS病毒的N-基因和S-基因产物的推断氨基酸序列以及在诊断方法中使用N-基因和S-基因产物。 本发明还包括诊断测定和试剂盒，其包含针对N-基因或S-基因产物产生的抗体。

    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    2.
    发明申请
    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的诊断测定

    公开(公告)号：US20050009009A1

    公开(公告)日：2005-01-13

    申请号：US10808187

    申请日：2004-03-24

    申请人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls

    发明人： Joseph Peiris ,  Kwok Yuen ,  Lit Poon ,  Yi Guan ,  Kwok Chan ,  John Nicholls

    IPC分类号： C07H21/04 ,  C07K16/08 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/701 ,  C07H21/04 ,  C12Q1/6844

    摘要： The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.

    摘要翻译： 本发明涉及在人类中引起严重急性呼吸综合征（SARS）的病毒的诊断测定法（“hSARS病毒”）。 特别地，本发明涉及使用逆转录和聚合酶链反应检测hSARS病毒的实时定量PCR测定。 具体地，定量测定是使用基于hSARS病毒基因组构建的引物和探针的TaqMan测定法。 本发明还涉及包含用于检测hSARS病毒的核酸分子的诊断试剂盒。

    Novel human virus causing respiratory tract infection and uses thereof
    3.
    发明申请
    Novel human virus causing respiratory tract infection and uses thereof 有权
    引起呼吸道感染的新型人类病毒及其用途

    公开(公告)号：US20060018923A1

    公开(公告)日：2006-01-26

    申请号：US10895064

    申请日：2004-07-21

    申请人： Kwok Yuen ,  Chiu Woo ,  Kar Lau ,  Kwok Chan ,  Lit Poon ,  Joseph Peiris ,  Yi Guan

    发明人： Kwok Yuen ,  Chiu Woo ,  Kar Lau ,  Kwok Chan ,  Lit Poon ,  Joseph Peiris ,  Yi Guan

    IPC分类号： A61K39/12 ,  C07H21/04 ,  C12N15/86 ,  C07K14/01

    CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

    摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

    摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

    Baicalin and its derivatives as a treatment for SARS coronavirus infection or other related infections
    4.
    发明申请
    Baicalin and its derivatives as a treatment for SARS coronavirus infection or other related infections 有权
    黄芩苷及其衍生物作为治疗SARS冠状病毒感染或其他相关感染

    公开(公告)号：US20050215494A1

    公开(公告)日：2005-09-29

    申请号：US10983985

    申请日：2004-11-08

    申请人： Kwok Yuen ,  Feng Chen ,  Kwok Chan ,  Yi Kao ,  Yi Guan ,  Leo Poon ,  Jsm Peiris

    发明人： Kwok Yuen ,  Feng Chen ,  Kwok Chan ,  Yi Kao ,  Yi Guan ,  Leo Poon ,  Jsm Peiris

    IPC分类号： A61K31/382 ,  A61K31/7048

    CPC分类号： A61K31/382 ,  A61K31/7048

    摘要： The present invention relates to a pharmaceutical composition useful for the treatment of diseases associated with viruses of the order Nidovirales of the family Coronaviradae, such as Severe Acute Respiratory Syndrome (SARS) viruses in humans and other animals. In particular, this invention relates to a naturally occurring compound, namely, baicalin, extracted and purified from the Chinese medicinal plant Scutellaria baicalensis Georgi (Chinese name: Huang Qin), that exhibits potent antiviral activity against members of the order Nidovirales of the family Coronaviradae that infects humans and other animals; in particular, SARS viruses in humans (“hSARS virus”). The invention also relates to a therapeutic method, using pharmaceutical compositions comprising baicalin compounds, for the treatment, amelioration, management or prevention of diseases associated with members of the order Nidovirales of the family Coronaviradae, such as hSARS.

    摘要翻译： 本发明涉及可用于治疗与冠状病毒家族的病毒相关的疾病的药物组合物，例如人和其他动物中的严重急性呼吸综合征（SARS）病毒。 特别地，本发明涉及一种天然存在的化合物，即黄芩苷，从中药材黄芩（中文名：黄秦）中提取和纯化，对抗冠状病毒家族的Nidovirales成员表现出强烈的抗病毒活性 感染人类和其他动物; 特别是人类中的SARS病毒（“hSARS病毒”）。 本发明还涉及使用包含黄芩苷化合物的药物组合物用于治疗，改善，管理或预防与冠状病毒家族（Norovirales）家族成员有关的疾病如hSARS的治疗方法。

    Human virus causing respiratory tract infection and uses thereof
    5.
    发明授权
    Human virus causing respiratory tract infection and uses thereof 有权
    引起呼吸道感染的人类病毒及其用途

    公开(公告)号：US07553944B2

    公开(公告)日：2009-06-30

    申请号：US10895064

    申请日：2004-07-21

    申请人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    发明人： Kwok Yung Yuen ,  Chiu Yat Patrick Woo ,  Kar Pui Susanna Lau ,  Kwok Hung Chan ,  Lit Man Poon ,  Joseph Sriyal Malik Peiris ,  Yi Guan

    IPC分类号： C07H21/02 ,  C12N15/00 ,  A61K39/00 ,  A61K39/12

    CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022

    摘要： The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen, China. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1.

    摘要翻译： 本发明提供了一种新型人冠状病毒的完整基因组序列，其创造为冠状病毒HKU1（“CoV-HKU1”），在香港从最近访问中国的深圳的病人中分离出来。 该病毒属于冠状病毒科家族的Nidovirales，是正极性的单链RNA病毒。 本发明还提供了CoV-HKU1的完整基因组的推导的氨基酸序列。 CoV-HKU1的核苷酸序列和推导的氨基酸序列可用于预防，诊断和/或治疗CoV-HKU1感染。 此外，本发明基于CoV-HKU1的核苷酸序列和推定的氨基酸序列，提供使用重组和嵌合形式以及CoV-HKU1的亚基的免疫原性和疫苗制剂。

    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
    7.
    发明授权
    Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS) 有权
    导致严重急性呼吸综合征（SARS）的人类病毒的诊断测定

    公开(公告)号：US07267942B2

    公开(公告)日：2007-09-11

    申请号：US10808187

    申请日：2004-03-24

    申请人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls

    发明人： Joseph S. M. Peiris ,  Kwok Yung Yuen ,  Lit Man Poon ,  Yi Guan ,  Kwok Hung Chan ,  John M. Nicholls

    IPC分类号： C12Q1/70 ,  C12N15/50

    CPC分类号： C12Q1/701 ,  C07H21/04 ,  C12Q1/6844

    摘要： The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time quantitative PCR assay for the detection of hSARS virus using reverse transcription and polymerase chain reaction. Specifically, the quantitative assay is a TaqMan® assay using the primers and probes constructed based on the genome of the hSARS virus. The invention further relates to a diagnostic kit that comprises nucleic acid molecules for the detection of the hSARS virus.

    摘要翻译： 本发明涉及在人类中引起严重急性呼吸综合征（SARS）的病毒的诊断测定法（“hSARS病毒”）。 特别地，本发明涉及使用逆转录和聚合酶链反应检测hSARS病毒的实时定量PCR测定。 具体地，定量测定是使用基于hSARS病毒基因组构建的引物和探针的TaqMan测定法。 本发明还涉及包含用于检测hSARS病毒的核酸分子的诊断试剂盒。

    System and methods for document retrieval using natural language-based queries
    9.
    发明授权
    System and methods for document retrieval using natural language-based queries 失效
    使用自然语言查询的文档检索系统和方法

    公开(公告)号：US06687689B1

    公开(公告)日：2004-02-03

    申请号：US09613849

    申请日：2000-07-11

    申请人： Pascale Fung ,  Chi Shun Cheung ,  Yi Guan ,  Yongsheng Yang

    发明人： Pascale Fung ,  Chi Shun Cheung ,  Yi Guan ,  Yongsheng Yang

    IPC分类号： G06F1730

    CPC分类号： G06F17/30672 ,  Y10S707/99933 ,  Y10S707/99936

    摘要： A system and associated methods identify documents relevant to an inputted natural-language user query. One associate method includes: selecting a set of keywords from the user query; determining at least one word, not necessarily found in the user query, that is semantically similar to a keyword of the set of keywords; using the set of keywords and the at least one word to determining a subset of word sets from a database of pre-stored word sets, wherein the pre-stored word sets are each pre-associated with at least one document; determining a plurality of word sets, from the subset of word sets, that is most semantically similar to the user query; and identifying documents that have been pre-associated with the plurality of word sets as being relevant to the natural-language user query.

    摘要翻译： 系统和相关方法识别与输入的自然语言用户查询相关的文档。 一个关联方法包括：从用户查询中选择一组关键字; 确定语义上类似于该组关键字的关键词的在用户查询中不一定找到的至少一个单词; 使用所述一组关键字和所述至少一个单词来从预先存储的单词集的数据库中确定单词组的子集，其中所述预先存储的单词集每个都与至少一个文档预先关联; 从所述词集的子集中确定在语义上类似于所述用户查询的多个单词集合; 以及将已经与所述多个单词集预先相关联的文档识别为与所述自然语言用户查询相关。