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    Hydroformylation Process for Pharmaceutical Intermediate
    11.
    发明申请
    Hydroformylation Process for Pharmaceutical Intermediate 审中-公开
    药物中间体的加氢甲酰化方法

    公开(公告)号：US20080027218A1

    公开(公告)日：2008-01-31

    申请号：US11587553

    申请日：2005-04-26

    Applicant: Edward Daugs ,  Wei-Jun Peng ,  Cynthia Rane

    Inventor： Edward Daugs ,  Wei-Jun Peng ,  Cynthia Rane

    IPC: C07D487/04 ,  C07C229/30 ,  C07D209/48

    CPC classification number: C07D471/04

    Abstract: The invention relates to an improved process for the preparation of an advanced synthetic intermediate of ACE inhibitors. In one aspect, the present invention is based on a novel process for the preparation of an aldehyde of formula (I), wherein (N)PrG is a protected amino group, R is an alkyl or aralkyl group and X1-4 are each independently H or a non-reacting substituent, which comprises hydroformylation of an α-olefin of formula (II), by reaction with syngas (CO/H2) in the presence of, as catalyst, a group VIII transition metal complex of a phosphorus-containing ligand. Aldehyde (I), the product of linear hydroformylation, is formed in preference to aldehyde (III). In another aspect of the invention, α-olefin (II) is a novel composition. The process to convert (II) to (I) enables an efficient manufacturing route to MDL 28,726 and analogues.

    Abstract translation: 本发明涉及用于制备ACE抑制剂的高级合成中间体的改进方法。 一方面，本发明是基于制备式（I）的醛的新方法，其中（N）PrG是保护的氨基，R是烷基或芳烷基 和X 1〜4各自独立地为H或非反应性取代基，其包括式（II）的α-烯烃的羰基化，通过与合成气（CO / H 2 在作为催化剂的情况下，含磷配体的第VIII族过渡金属配合物存在下进行。 醛（I）是线性加氢甲酰化的产物，优先于醛（III）。 在本发明的另一方面，α-烯烃（II）是一种新的组合物。 将（II）转化为（I）的过程能够实现MDL 28,726和类似物的有效制造路线。

    Calixarene bisphosphite ligand for use in hydroformylation processes
    14.
    发明授权
    Calixarene bisphosphite ligand for use in hydroformylation processes 有权
    用于加氢甲酰化方法的杯芳烃二亚磷酸酯配体

    公开(公告)号：US07906688B2

    公开(公告)日：2011-03-15

    申请号：US12593296

    申请日：2008-04-03

    Applicant: Michael A. Brammer ,  Wei-Jun Peng ,  John M. Maher

    Inventor： Michael A. Brammer ,  Wei-Jun Peng ,  John M. Maher

    IPC: C07C45/50 ,  C07F9/02 ,  B01J31/00

    CPC classification number: C07C45/50 ,  C07F9/65746 ,  C07F15/0073 ,  C07C47/02

    Abstract: A calixarene bisphosphite composition for use as a ligand in a transition metal-ligand complex catalyst and in a complex catalyst precursor. The ligand is especially useful in catalysts and catalyst precursors for hydroformylation processes wherein a raffinate stream comprising a mixture of alpha, beta, and iso-olefinic isomers is hydroformylated in the presence of carbon monoxide, hydrogen, and the transition metal-ligand complex catalyst to form a mixture of linear and branched aldehyde products. The complex catalyst selectively converts the alpha and beta olefin reactants more rapidly than the iso-olefin reactant resulting in an improved molar ratio of normal (linear) to branched aldehyde products. The unconverted iso-olefinic isomer is thereafter readily separated from the aldehyde product mixture.

    Abstract translation: 用作过渡金属 - 配体配合物催化剂和复合催化剂前体中的配体的杯芳烃二亚磷酸酯组合物。 该配体特别可用于加氢甲酰化方法的催化剂和催化剂前体，其中包含α，β和异烯属异构体的混合物的残液流在一氧化碳，氢气和过渡金属 - 配体配合物催化剂存在下加氢甲酰化， 形成直链和支链醛产物的混合物。 复合催化剂选择性地将α和β烯烃反应物转化成比异烯烃反应物更快的速率，导致正常（线性）对支链醛产物的改善的摩尔比。 然后将未转化的异烯烃异构体从醛产物混合物中容易地分离。

    CALIXARENE BISPHOSPHITE LIGAND FOR USE IN HYDROFORMYLATION PROCESSES
    15.
    发明申请
    CALIXARENE BISPHOSPHITE LIGAND FOR USE IN HYDROFORMYLATION PROCESSES 有权
    CALIXARENE BISPHOSPHITE LIGAND用于氢化方法

    公开(公告)号：US20100044628A1

    公开(公告)日：2010-02-25

    申请号：US12593296

    申请日：2008-04-03

    Applicant: Michael A. Brammer ,  Wei-Jun Peng ,  John M. Maher

    Inventor： Michael A. Brammer ,  Wei-Jun Peng ,  John M. Maher

    IPC: C09K3/00 ,  C07F9/02 ,  C07F17/02 ,  B01J31/12

    CPC classification number: C07C45/50 ,  C07F9/65746 ,  C07F15/0073 ,  C07C47/02

    Abstract: A calixarene bisphosphite composition for use as a ligand in a transition metal-ligand complex catalyst and in a complex catalyst precursor. The ligand is especially useful in catalysts and catalyst precursors for hydroformylation processes wherein a raffinate stream comprising a mixture of alpha, beta, and iso-olefinic isomers is hydroformylated in the presence of carbon monoxide, hydrogen, and the transition metal-ligand complex catalyst to form a mixture of linear and branched aldehyde products. The complex catalyst selectively converts the alpha and beta olefin reactants more rapidly than the iso-olefin reactant resulting in an improved molar ratio of normal (linear) to branched aldehyde products. The unconverted iso-olefinic isomer is thereafter readily separated from the aldehyde product mixture.

    Abstract translation: 用作过渡金属 - 配体配合物催化剂和复合催化剂前体中的配体的杯芳烃二亚磷酸酯组合物。 该配体特别可用于加氢甲酰化方法的催化剂和催化剂前体，其中包含α，β和异烯属异构体的混合物的残液流在一氧化碳，氢气和过渡金属 - 配体配合物催化剂存在下加氢甲酰化， 形成直链和支链醛产物的混合物。 复合催化剂选择性地将α和β烯烃反应物转化成比异烯烃反应物更快的速率，导致正常（线性）对支链醛产物的改善的摩尔比。 然后将未转化的异烯烃异构体从醛产物混合物中容易地分离。

    Hydroformylation process and product separation with improved recovery of rhodium
    16.
    发明授权
    Hydroformylation process and product separation with improved recovery of rhodium 有权
    加氢甲酰化工艺和产物分离，提高铑的回收率

    公开(公告)号：US07663002B2

    公开(公告)日：2010-02-16

    申请号：US12299853

    申请日：2007-04-17

    Applicant: Wei-Jun Peng ,  Kurt D. Olson ,  Donald L. Morrison ,  Brian M. Roesch ,  Donald L. Bunning ,  Jeffrey G. Hippler ,  Vincent J. Stricker

    Inventor： Wei-Jun Peng ,  Kurt D. Olson ,  Donald L. Morrison ,  Brian M. Roesch ,  Donald L. Bunning ,  Jeffrey G. Hippler ,  Vincent J. Stricker

    IPC: C07C45/50

    CPC classification number: C07C45/80 ,  C07C45/50 ,  C07C67/347 ,  Y02P20/584 ,  C07C69/738 ,  C07C69/716 ,  C07C47/02

    Abstract: A non-aqueous hydroformylation process with liquid catalyst recycle involving a hydroformylation step and one or more stages of phase separation to recover a high molecular weight aldehyde product with efficient recovery of rhodium catalyst. The process includes a hydroformylation step to prepare a non-aqueous hydroformylation reaction product composition comprising one or more aldehyde products, one or more conjugated polyolefins, a rhodium-organophosphorus ligand complex, free organophosphorus ligand, and an organic solubilizing agent for said complex and said free ligand, and thereafter one or more stages of phase separation using added water under a carbon monoxide gas, hydrogen gas, or a mixture thereof. The process requires a specific range of total pressure for the hydroformylation, a specific range of total pressure for at least one of the separation stages, and a minimum sum of the total pressure of the hydroformylation step and the total pressure of the separation stage containing said gas.

    Abstract translation: 具有液体催化剂循环的非水羰基化方法，其涉及加氢甲酰化步骤和一个或多个相分离阶段以回收高分子量醛产物并有效回收铑催化剂。 该方法包括加氢甲酰化步骤，以制备包含一种或多种醛产物，一种或多种共轭聚烯烃，铑 - 有机磷配体络合物，游离有机磷配体和用于所述络合物的有机增溶剂的非水羰基化反应产物组合物和所述 游离配体，然后在一氧化碳气体，氢气或其混合物中使用加入的水进行一个或多个相分离阶段。 该方法需要加氢甲酰化的总压力的特定范围，至少一个分离阶段的总压力的特定范围，以及加氢甲酰化步骤的总压力和含有所述分离阶段的分离阶段的总压力的最小总和 加油站。

    Bis-chelating ligand and use thereof in carbonylation processes
    18.
    发明授权
    Bis-chelating ligand and use thereof in carbonylation processes 有权
    双螯合配体及其在羰基化过程中的应用

    公开(公告)号：US07294729B2

    公开(公告)日：2007-11-13

    申请号：US10527568

    申请日：2003-09-26

    Applicant: Wei-Jun Peng ,  Johnathan E Holladay

    Inventor： Wei-Jun Peng ,  Johnathan E Holladay

    IPC: C07F15/00 ,  C07F9/02 ,  B01J31/00

    CPC classification number: C07F15/008 ,  B01J31/1608 ,  B01J31/185 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/845 ,  C07C45/50 ,  C07F9/65746 ,  C07C47/42

    Abstract: A novel bis-chelating composition characterized by formula I: wherein M is a Group VB element; R1 and R2 are each independently selected from hydrogen and monovalent hydrocarbyl radicals; or R1 and R2 are bonded together to form a diradical; or one of R1 or R2 is hydrogen or a monovalent hydrocarbyl radical, while the other of R1 or R2 is a hydrocarbyl radical bonded to an atom in Ar; wherein Ar is selected from 1,2-arylenes; Q is selected from 1,2-arylenes, 2,2′-bisarylenes and alkyl diradicals; and W is selected from II, III, IV, or V: wherein M is as defined hereinbefore; each R is independently selected from hydrogen and monovalent hydrocarbyl radicals; X is selected from alkyl and aryl diradicals; Ar1 and Ar2 are each independently selected from 1,2-arylenes;Ar3 and Ar4 are each independently selected from monovalent aryl radicals; and n in formula IV is 0 or 1. The composition finds utility as a ligand in catalysts for carbonylation processes

    Abstract translation: 特征在于式I的新型双螯合组合物：其中M是VB族元素; R1和R2各自独立地选自氢和一价烃基; 或者R 1和R 2结合在一起形成双基; 或R 1或R 2中的一个为氢或一价烃基，而R 1或R 2中的另一个为与Ar中的原子键合的烃基; 其中Ar选自1,2-亚芳基; Q选自1,2-亚芳基，2,2'-双芳烯和烷基双基; W选自II，III，IV或V：其中M如上所定义; 每个R独立地选自氢和一价烃基; X选自烷基和芳基双基; Ar 1和Ar 2各自独立地选自1,2-亚芳基; Ar 3和Ar 4是 各自独立地选自一价芳基; 式IV中的n为0或1.该组合物用作用于羰基化方法的催化剂中的配体

    EXTRACTION PROCESS FOR ALDEHYDE PRODUCT SEPARATION AND CATALYST RECOVERY
    20.
    发明申请
    EXTRACTION PROCESS FOR ALDEHYDE PRODUCT SEPARATION AND CATALYST RECOVERY 失效
    阿尔德产品分离和催化剂回收的萃取方法

    公开(公告)号：US20100228057A1

    公开(公告)日：2010-09-09

    申请号：US12664220

    申请日：2008-05-30

    Applicant: Wei-Jun Peng

    Inventor： Wei-Jun Peng

    IPC: C07C45/78

    CPC classification number: C11C3/00 ,  C07C67/347 ,  C07C67/58 ,  C07C69/716

    Abstract: An extraction process for a non-aqueous hydroformylation product composition to separate an aldehyde product and to recover a hydroformylation catalyst. The process involves mixing a non-aqueous hydroformylation product composition containing a mixture of formyl-substituted fatty acid triglyceride esters derived from hydroformylating a seed oil, a transition metal-organophosphine ligand wherein the organophosphine is ionically-charged, optionally free ionically-charged organophosphine ligand, and a polar organic solubilizing agent with water and an extraction solvent having low water solubility to recover an organic phase containing the mixture of formyl-substituted fatty acid triglycerides and the low solubility extraction solvent and an aqueous phase containing the transition metal-organophosphine ligand, optional free ligand, the organic solubilizing agent, and water. Optionally, the low solubility extraction solvent can be prepared in situ in the hydroformylation step.

    Abstract translation: 用于非水羰基化产物组合物分离醛产物并回收加氢甲酰化催化剂的提取方法。 该方法包括混合含有衍生自加氢甲酰化种子油的甲酰取代的脂肪酸甘油三酸酯混合物的非水性加氢甲酰化产物组合物，其中有机膦被离子带电的过渡金属 - 有机膦配体，任选的游离离子电荷的有机膦配体 和具有低水溶性的水和萃取溶剂的极性有机增溶剂，以回收含有甲酰取代的脂肪酸甘油三酸酯和低溶解度提取溶剂的混合物的有机相和含有过渡金属 - 有机膦配体的水相， 任选的游离配体，有机增溶剂和水。 任选地，低溶解度提取溶剂可以在加氢甲酰化步骤中原位制备。

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