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11.发明授权Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade 失效新颖的烯醇酰胺，药物组合物及其用于花生四烯酸级联调节剂的活性的方法
公开(公告)号：US4868195A
公开(公告)日：1989-09-19
申请号：US165045
申请日：1988-03-07
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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12.发明授权N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade 失效N-取代-2-羟基-α-氧代苯乙酰胺和具有作为花生四烯酸级联的调节剂的活性的药物组合物
公开(公告)号：US4939133A
公开(公告)日：1990-07-03
申请号：US782763
申请日：1985-10-01
申请人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
发明人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： C12N9/99 , A61K31/165 , A61K31/215 , A61K31/24 , A61K31/27 , A61P9/00 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C67/00 , C07C225/22 , C07C227/00 , C07C229/42 , C07C229/44 , C07C231/02 , C07C233/12 , C07C235/64 , C07C235/72 , C07C301/00 , C07C303/40 , C07C311/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C317/48 , C07C323/12
CPC分类号： A61K31/165 , C07C233/12
摘要： The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-.alpha.-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.
摘要翻译： 本发明涉及新型N-取代的2-羟基苯甲酰胺和N-取代的2-羟基-α-氧代 - 乙烯乙酰胺化合物药物组合物，以及用于治疗其中具有脂氧合酶活性的产物有助于 病理状况。 选择的新型中间体也是本发明。
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13.发明授权Enolamides, pharmaceutical compositions and methods of use thereof for treating inflammation 失效烯酰胺，药物组合物及其用于治疗炎症的方法
公开(公告)号：US4921871A
公开(公告)日：1990-05-01
申请号：US121264
申请日：1987-11-16
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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公开(公告)号：US4703053A
公开(公告)日：1987-10-27
申请号：US790664
申请日：1985-10-28
IPC分类号： C07D307/85 , C07D307/86 , C07D307/92 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , A61K31/41
CPC分类号： C07D307/92 , C07C323/00 , C07D307/85 , C07D307/86 , C07D333/70 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12
摘要： Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The disclosure describes the use of derivatives for prevention of the release of mediators including histamine and leukotrienes from basophils and mast cells, and prevent respiratory burst in neutrophils providing activity useful in cardiovascular disorders as well as in antiinflammatory, psoriasis, and antimigraine treatment.
摘要翻译： 描述了具有抗变应性活性的新型苯并噻吩和苯并呋喃衍生物以及其制备方法，药物组合物及其使用方法。 本公开内容描述了用于预防从嗜碱性粒细胞和肥大细胞释放包括组胺和白三烯的介质的衍生物的用途，以及预防嗜中性粒细胞的呼吸爆发，提供可用于心血管疾病以及抗炎，银屑病和抗偏头痛治疗的活性。
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15.发明授权3-[2-(Mono-and dialkylamino)propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-C]pyridin- 5-ones useful for treating bronchospastic diseases 失效丙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-C]吡啶-5-酮可用于治疗支气管痉挛性疾病
公开(公告)号：US4382939A
公开(公告)日：1983-05-10
申请号：US351554
申请日：1982-02-23
IPC分类号： A61K31/435 , A61P11/00 , C07D491/04 , C07D491/052 , A61K31/455
CPC分类号： C07D491/04
摘要： Anticholinergic 3-[2-(mono- and dialkylamino)-propyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]-pyridin-5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.A method for preparing the intermediate which is required to prepare the unsubstituted benzopyrano-[3,4-c]pyridin-5-ones of the invention is also disclosed.
摘要翻译： 抗胆碱能的3- [2-（单 - 和二烷基氨基） - 丙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c] - 吡啶-5-酮可用于治疗支气管痉挛 公开了哺乳动物的疾病。 还公开了制备所述化合物的方法，含有它们的药物组合物和使用所述药物组合物的方法。 还公开了制备本发明的未取代的苯并吡喃并[3,4-c]吡啶-5-酮所需中间体的方法。
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16.发明授权3-[2-(Azabicyclo) ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones 失效3- [2-（氮杂双环）乙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c]吡啶-5-酮
公开(公告)号：US4404138A
公开(公告)日：1983-09-13
申请号：US391197
申请日：1982-06-22
IPC分类号： C07D453/06 , A61K31/435 , A61P11/08 , C07D491/04 , C07D491/052 , C07D491/14 , C07D519/00
CPC分类号： C07D491/04 , C07D491/14 , Y10S514/826
摘要： Anticholinergic 3-[2-(azabicyclo)ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositions containing them and methods for using said pharmaceutical compositions.
摘要翻译： 公开了用于治疗哺乳动物支气管痉挛疾病的抗胆碱能3-3- [2-（氮杂双环）乙基] -1,2,3,4-四氢-5H- [1]苯并吡喃并[3,4-c]吡啶-5- 。 还公开了制备所述化合物的方法，含有它们的药物组合物和使用所述药物组合物的方法。
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17.发明授权Novel enolamides, pharmaceutical compositions and methods of use thereof for activity as modulators of the arachidonic acid cascade 失效新颖的烯醇酰胺，药物组合物及其用于花生四烯酸级联调节剂的活性的方法
公开(公告)号：US4874758A
公开(公告)日：1989-10-17
申请号：US164355
申请日：1988-03-04
申请人： Mary E. Carethers , Wiaczeslaw A. Centenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Centenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and method of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗脂氧合酶活性产物或白三烯的作用对病理状况的作用。
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18.发明授权Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents 失效酸性四唑基取代的吲哚化合物及其作为抗过敏剂的用途
公开(公告)号：US4675332A
公开(公告)日：1987-06-23
申请号：US788111
申请日：1985-10-21
IPC分类号： A61K31/41 , A61P9/00 , A61P25/04 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/42 , C07D403/04 , C07D403/12 , C07D405/14 , C07D491/056
CPC分类号： C07D403/04 , C07D209/42 , C07D403/12
摘要： Novel acidic indole compounds having use as antiallergic agents, methods of synthesis, compositions, and uses are claimed.
摘要翻译： 用作抗变应性剂的新型酸性吲哚化合物，合成方法，组合物和用途被要求保护。
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19.发明授权Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV 失效苯并噻吩，苯并呋喃和吲哚 - 噻吩酮，氧氮杂酮和二氮杂酮作为细胞粘附的抑制剂和HIV的抑制剂
公开(公告)号：US5565446A
公开(公告)日：1996-10-15
申请号：US444975
申请日：1995-05-19
IPC分类号： C07D487/04 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P29/00 , A61P31/12 , A61P37/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/551 , A61K31/553 , A61K31/554 , C07D513/04
摘要： Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immunodeficiency virus (HIV).
摘要翻译： 苯并噻吩，苯并呋喃和吲哚噻嗪酮，氧氮杂酮和二氮杂酮及其制备方法被描述为抑制白细胞粘附于血管内皮的药剂，因此是用于治疗炎性疾病的有效治疗剂; 这些化合物也抑制人体免疫缺陷病毒（HIV）的活化。
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公开(公告)号：US5489586A
公开(公告)日：1996-02-06
申请号：US351611
申请日：1994-12-12
IPC分类号： C07D487/04 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P29/00 , A61P31/12 , A61P37/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/551 , A61K31/553 , A61K31/554 , C07D513/04
摘要： Benzothiophene, benzofuran and indole-thiazepinones, oxazepinones and diazepinones as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases.
摘要翻译： 苯并噻吩，苯并呋喃和吲哚 - 硫氮酮，氧氮杂酮和二氮杂酮及其制备方法被描述为抑制白细胞粘附于血管内皮的试剂，因此是用于治疗炎性疾病的有效治疗剂。
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