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    Fermentation and purification process for succinic acid
    14.
    发明授权
    Fermentation and purification process for succinic acid 失效
    琥珀酸的发酵和纯化过程

    公开(公告)号：US5168055A

    公开(公告)日：1992-12-01

    申请号：US372721

    申请日：1989-06-28

    申请人： Rathin Datta ,  David A. Glassner ,  Mahendra K. Jain ,  John R. Vick Roy

    发明人： Rathin Datta ,  David A. Glassner ,  Mahendra K. Jain ,  John R. Vick Roy

    IPC分类号： C07C51/02 ,  C07C51/487 ,  C07C55/10 ,  C12P7/46 ,  C12R1/01

    CPC分类号： C07C51/02 ,  C12P7/46 ,  Y10S435/822

    摘要： A process for economically producing highly purified succinic acid comprises growing a succinate-producing microorganism on a low cost carbohydrate substrate; simultaneously neutralizing the fermentation broth and precipitating the succinate as calcium succinate by adding a calcium ion source to form calcium succinate; isolating the calcium succinate; slurrying the calcium succinate in water and treating it with sulfuric acid to form calcium sulfate and succinic acid; and then treating the succinic acid with first a strongly acidic ion exchanger and then a weakly basic ion exchanger to remove impurities and obtain a highly purified succinic acid product. In a preferred embodiment, the calcium succinate is isolated from the fermentation broth by filtration; the filtrate is heated to precipitate additional calcium succinate; and, the spent filtrate which contains nutrients is recycled to the fermentor.

    摘要翻译： 经济地生产高纯度琥珀酸的方法包括在低成本碳水化合物底物上生长琥珀酸生产微生物; 同时中和发酵肉汤，并通过加入钙离子源形成琥珀酸钙沉淀琥珀酸钙作为琥珀酸钙; 分离琥珀酸钙; 将琥珀酸钙在水中制浆并用硫酸处理形成硫酸钙和琥珀酸; 然后用强酸性离子交换剂处理琥珀酸，然后用弱碱性离子交换剂处理琥珀酸，除去杂质，得到高纯度的琥珀酸产物。 在优选的实施方案中，通过过滤从发酵液中分离琥珀酸钙; 加热滤液以沉淀附加的琥珀酸钙; 将含有营养物质的废滤液再循环到发酵罐中。

    Process for the production and purification of succinic acid
    17.
    发明授权
    Process for the production and purification of succinic acid 失效
    生产和纯化琥珀酸的方法

    公开(公告)号：US5143834A

    公开(公告)日：1992-09-01

    申请号：US325404

    申请日：1989-03-17

    申请人： David A. Glassner ,  Rathin Datta

    发明人： David A. Glassner ,  Rathin Datta

    IPC分类号： C07C51/02 ,  C07C55/10 ,  C12P7/46 ,  C12R1/01

    CPC分类号： C12P7/46 ,  C07C51/02 ,  Y10S435/822

    摘要： A process for producing and purifying succinic acid comprises growing a succinate salt-producing microorganism on an inexpensive substrate containing carbohydrate, other nutrients, sodium ions and tryptophan under a CO.sub.2 partial pressure until most of the carbohydrate is converted to succinate. The fermentation broth is then electrodialyzed to recover and concentrate the succinate salt in an aqueous stream which is subjected to water-splitting electrodialysis to form base and a succinic acid product. The resulting succinc acid product is treated first with a strongly acidic ion exchanger in the acid form to remove any sodium or other cations and then treated with a weakly basic ion exchanger in the free base form to remove any sulfate ions or sulfuric acid and to obtain a highly purified succinic acid product.

    摘要翻译： 制备和纯化琥珀酸的方法包括在CO 2分压下在含有碳水化合物，其它营养物，钠离子和色氨酸的便宜的底物上生长琥珀酸盐产生微生物，直到大部分碳水化合物转化为琥珀酸。 然后将发酵液进行电渗析以回收并浓缩琥珀酸盐在水流中，其进行水分解电渗析以形成碱和琥珀酸产物。 所得的琥珀酸产物首先用酸形式的强酸性离子交换剂处理以除去任何钠或其它阳离子，然后用游离碱形式的弱碱性离子交换剂处理以除去任何硫酸根离子或硫酸，并获得 高纯度琥珀酸产品。