Fermentation and purification process for succinic acid
    6.
    发明授权
    Fermentation and purification process for succinic acid 失效
    琥珀酸的发酵和纯化过程

    公开(公告)号:US5168055A

    公开(公告)日:1992-12-01

    申请号:US372721

    申请日:1989-06-28

    摘要: A process for economically producing highly purified succinic acid comprises growing a succinate-producing microorganism on a low cost carbohydrate substrate; simultaneously neutralizing the fermentation broth and precipitating the succinate as calcium succinate by adding a calcium ion source to form calcium succinate; isolating the calcium succinate; slurrying the calcium succinate in water and treating it with sulfuric acid to form calcium sulfate and succinic acid; and then treating the succinic acid with first a strongly acidic ion exchanger and then a weakly basic ion exchanger to remove impurities and obtain a highly purified succinic acid product. In a preferred embodiment, the calcium succinate is isolated from the fermentation broth by filtration; the filtrate is heated to precipitate additional calcium succinate; and, the spent filtrate which contains nutrients is recycled to the fermentor.

    摘要翻译: 经济地生产高纯度琥珀酸的方法包括在低成本碳水化合物底物上生长琥珀酸生产微生物; 同时中和发酵肉汤,并通过加入钙离子源形成琥珀酸钙沉淀琥珀酸钙作为琥珀酸钙; 分离琥珀酸钙; 将琥珀酸钙在水中制浆并用硫酸处理形成硫酸钙和琥珀酸; 然后用强酸性离子交换剂处理琥珀酸,然后用弱碱性离子交换剂处理琥珀酸,除去杂质,得到高纯度的琥珀酸产物。 在优选的实施方案中,通过过滤从发酵液中分离琥珀酸钙; 加热滤液以沉淀附加的琥珀酸钙; 将含有营养物质的废滤液再循环到发酵罐中。