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23 条记录 (耗时 0.064 秒)

    Selected Haemophilus influenzae Rd polynucleotides and polypeptides
    13.
    发明授权
    Selected Haemophilus influenzae Rd polynucleotides and polypeptides 失效
    选定的流感嗜血杆菌Rd多核苷酸和多肽

    公开(公告)号：US06468765B1

    公开(公告)日：2002-10-22

    申请号：US08487429

    申请日：1995-06-07

    申请人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    发明人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    IPC分类号： G12P2102

    CPC分类号： C07K14/285

    摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.

    摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。 本发明还提供存储在计算机可读介质上的序列信息，以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组

    Human stanniocalcin-alpha
    14.
    发明授权
    Human stanniocalcin-alpha 失效
    人类猕猴桃

    公开(公告)号：US06613877B2

    公开(公告)日：2003-09-02

    申请号：US09361736

    申请日：1999-07-28

    申请人： Henrick S. Olsen ,  Robert D. Fleischmann

    发明人： Henrick S. Olsen ,  Robert D. Fleischmann

    IPC分类号： C07K1400

    CPC分类号： C07H21/04 ,  C07K14/575

    摘要： A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use in the regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类猕猴素α多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来调节可导致肾，骨和心脏病以及骨质疏松症和佩吉特氏病的电解质不平衡的方法。 还公开了抗这些多肽的拮抗剂及其在调节可导致低钙血症和骨质疏松症的电解质不平衡中的用途。

    Neurotransmitter transporter
    16.
    发明授权
    Neurotransmitter transporter 失效
    神经递质转运蛋白

    公开(公告)号：US5759854A

    公开(公告)日：1998-06-02

    申请号：US424424

    申请日：1995-04-21

    申请人： Yi Li ,  Robert D. Fleischmann

    发明人： Yi Li ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： Disclosed is a neurotransmitter transporter protein and DNA (RNA) encoding such protein. Also provided is a procedure for producing such polypeptide by recombinant techniques. The procedure for producing antagonists/inhibitors against such polypeptide is also provided. Such antagonists/inhibitors may be used to inhibit the action of neurotransmitter transporter protein for treatment of depression, anxiety of epilepsy.

    摘要翻译： PCT No.PCT / US94 / 05363 Sec。 371日期1995年04月21日 102（e）日期1995年4月21日PCT 1994年5月16日PCT PCT。 公开号WO95 / 31539 日期1995年11月23日公开是编码这种蛋白质的神经递质转运蛋白和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还提供了产生针对这种多肽的拮抗剂/抑制剂的方法。 这样的拮抗剂/抑制剂可用于抑制神经递质转运蛋白用于治疗抑郁症，癫痫焦虑的作用。

    Human tumor necrosis factor receptor
    17.
    发明授权
    Human tumor necrosis factor receptor 失效

    公开(公告)号：US07094564B1

    公开(公告)日：2006-08-22

    申请号：US08469637

    申请日：1995-06-06

    申请人： John Greene ,  Robert D. Fleischmann

    发明人： John Greene ,  Robert D. Fleischmann

    IPC分类号： G12N15/12 ,  G12N5/10

    CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K14/7151 ,  C12N2799/026

    摘要： A human TNF receptor and DNA (RNA) encoding such receptor and a procedure for producing such receptor by recombinant techniques is disclosed. Also disclosed are methods for utilizing such receptor for screening for antagonists and agonists to the receptor and for ligands for the receptor. Also disclosed are methods for utilizing such agonists to inhibit the growth of tumors, to stimulate cellular differentiation, to mediate the immune response and anti-viral response, to regulate growth and provide resistance to certain infections. The use of the antagonists as a therapeutic to treat autoimmune diseases, inflammation, septic shock, to inhibit graft-host reactions, and to prevent apoptosis is also disclosed. Also disclosed are diagnostic methods for detecting mutations in the nucleic acid sequence encoding the receptor and for detecting altered levels of the soluble receptor in a sample derived from a host.

    Human stanniocalcin-alpha
    18.
    发明授权
    Human stanniocalcin-alpha 失效
    人类猕猴桃

    公开(公告)号：US06955885B2

    公开(公告)日：2005-10-18

    申请号：US10418226

    申请日：2003-04-18

    申请人： Henrik S. Olsen ,  Robert D. Fleischmann

    发明人： Henrik S. Olsen ,  Robert D. Fleischmann

    IPC分类号： C07H21/04 ,  C07K14/56 ,  C07K14/575 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C07K16/22 ,  C12N5/12 ,  G01N33/53

    CPC分类号： C07H21/04 ,  C07K14/575

    摘要： A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use in the regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to detect diseases or the susceptibility to diseases related to a mutated form of stanniocalcin-alpha sequences is also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类猕猴素α多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来调节可导致肾，骨和心脏病以及骨质疏松症和佩吉特氏病的电解质不平衡的方法。 还公开了抗这些多肽的拮抗剂及其在调节可导致低钙血症和骨质疏松症的电解质不平衡中的用途。 还公开了将斯诺钙钙素α序列用作诊断疾病或与突变形式的锡氨钙素-α序列相关的疾病的易感性的用途。

    DNA encoding retinotic acid receptor epsilon
    20.
    发明授权
    DNA encoding retinotic acid receptor epsilon 失效
    编码视黄酸受体ε的DNA

    公开(公告)号：US5869284A

    公开(公告)日：1999-02-09

    申请号：US466120

    申请日：1995-06-06

    申请人： Liang Cao ,  Jian Ni ,  Robert D. Fleischmann

    发明人： Liang Cao ,  Jian Ni ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C12N5/06 ,  C12N15/12 ,  C12P21/02 ,  C12P21/00

    CPC分类号： C07K14/70567 ,  A61K38/00 ,  C12N2799/026

    摘要： Disclosed is a retinoic acid receptor epsilon (RAR.epsilon.) polynucleotide and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, tissue regeneration and stimulation of the immune and hematopoietic system. Also disclosed are methods of identifying ligands which stimulate the RAR.epsilon.. Also disclosed are diagnostic methods for detecting a mutation in the RAR.epsilon. receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了视黄酸受体ε（RARε）多核苷酸和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，并且利用这种多肽用于治疗目的，例如组织再生和免疫和造血系统的刺激。 还公开了鉴定刺激RARε的配体的方法。 还公开了用于检测RARε受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。