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    Stent delivery catheter with improved stent retention and method of making same
    13.
    发明授权
    Stent delivery catheter with improved stent retention and method of making same 有权
    支架输送导管具有改善的支架保留率和制作方法

    公开(公告)号：US08512388B1

    公开(公告)日：2013-08-20

    申请号：US10877873

    申请日：2004-06-24

    Applicant: Wouter Roorda ,  Tim A. Limon ,  Stephen D. Pacetti

    Inventor： Wouter Roorda ,  Tim A. Limon ,  Stephen D. Pacetti

    IPC: A61F2/06

    CPC classification number: A61F2/958 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2230/0054 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    Abstract: A stent delivery catheter system having a catheter with stent releasably mounted on a stent retention portion of the catheter for delivery and deployment within a patient's body lumen, and a method of mounting the stent on the stent retention portion of the catheter. The method generally includes exposing the stent retention portion and/or the stent to a solvent, the solvent being in the vapor phase. The vapor phase solvent typically softens the stent retention portion of the catheter, and/or, in one embodiment in which the stent has a coating on the stent body, the vapor phase solvent softens the stent coating. In a presently preferred embodiment, the stent polymeric coating has a therapeutic agent, and the method of the invention prevents or inhibits disadvantageously affecting the therapeutic agent coating during mounting of the stent on the catheter.

    Abstract translation: 一种具有导管的支架输送导管系统，其具有可释放地安装在导管的支架保持部分上的支架，用于在患者的体腔内输送和展开，以及将支架安装在导管的支架保持部分上的方法。 该方法通常包括将支架保持部分和/或支架暴露于溶剂中，溶剂处于气相。 气相溶剂通常软化导管的支架保留部分，和/或在其中支架在支架主体上具有涂层的一个实施例中，气相溶剂软化支架涂层。 在目前优选的实施方案中，支架聚合物涂层具有治疗剂，并且本发明的方法在将支架安装在导管上时防止或抑制不利地影响治疗剂涂层。

    Methods, devices, and apparatus for managing access through tissue
    17.
    发明授权
    Methods, devices, and apparatus for managing access through tissue 有权
    用于管理通过组织进入的方法，装置和装置

    公开(公告)号：US08226681B2

    公开(公告)日：2012-07-24

    申请号：US11767818

    申请日：2007-06-25

    Applicant: Ian J. Clark ,  Wouter Roorda

    Inventor： Ian J. Clark ,  Wouter Roorda

    IPC: A61B17/08

    CPC classification number: A61B17/0057 ,  A61B17/083 ,  A61B17/10 ,  A61B2017/00637 ,  A61B2017/00668

    Abstract: Devices and methods for managing access through tissue is disclosed. The device includes a body. The body is movable from a pre-deployed configuration towards a deployed configuration. The device includes a plurality of tissue engaging portions that extend from the body. At least a portion of the tissue engaging portions are obtuse. At least two of the tissue engaging portions are separated by a first distance in the deployed configuration and a second distance in the pre-deployed configuration. The first distance is smaller than the second distance. The method includes deploying a closure element to tissue adjacent a tissue opening to substantially close the opening following a first procedure. The method also includes selectively opening the opening in the tissue by advancing a distal end of a medical device through the deployed closure element as a part of or before a second procedure.

    Abstract translation: 公开了用于管理通过组织进入的装置和方法。 该装置包括一个主体。 身体可以从预部署配置朝向部署配置移动。 该装置包括从身体延伸的多个组织接合部分。 组织接合部分的至少一部分是钝的。 组织接合部分中的至少两个在展开配置中分开第一距离，并且在预部署配置中分开第二距离。 第一距离小于第二距离。 该方法包括将封闭元件部署到邻近组织开口的组织，以在第一程序之后基本上关闭开口。 该方法还包括通过使医疗装置的远端作为第二程序的一部分或之前通过展开的闭合元件前进而选择性地打开组织中的开口。

    Zwitterionic copolymers, method of making and use on medical devices
    18.
    发明授权
    Zwitterionic copolymers, method of making and use on medical devices 有权
    两性离子共聚物，制造和使用在医疗器械上的方法

    公开(公告)号：US07781551B2

    公开(公告)日：2010-08-24

    申请号：US11942693

    申请日：2007-11-19

    Applicant: Stephen Pacetti ,  Wouter Roorda

    Inventor： Stephen Pacetti ,  Wouter Roorda

    IPC: C08F12/30 ,  C08F12/26 ,  C08F20/26

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or 2-ethoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.

    Abstract translation: 制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。 烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-乙氧基乙酯（EOEMA）。 或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。 烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。 改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

    METHODS OF USING MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE
    20.
    发明申请
    METHODS OF USING MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE 审中-公开
    用于控制药物释放的医疗器械的方法

    公开(公告)号：US20080057103A1

    公开(公告)日：2008-03-06

    申请号：US11839121

    申请日：2007-08-15

    Applicant: Wouter Roorda

    Inventor： Wouter Roorda

    IPC: A61F2/02 ,  A61F2/82 ,  A61P41/00 ,  A61P9/00

    CPC classification number: A61K31/436 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/608 ,  B22F3/008 ,  B22F3/105 ,  B22F2003/1051 ,  B22F2003/1054

    Abstract: The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.

    Abstract translation: 本发明是用于控制活性剂释放的医疗装置。 医疗器具具有设置在其中的多孔体的支撑结构。 含有有效量的至少一种活性剂的至少一种洗脱速率控制基质以保护基质免受机械损伤的方式设置在多孔体的孔内。 因此，医疗装置可用于受控药物释放应用。 另外，本发明公开了一种使用该医疗装置来治疗和预防哺乳动物疾病的方法。 本发明还涉及一种用于治疗和预防血管疾病的医疗装置的方法。

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