公开(公告)号：US20150157588A1

公开(公告)日：2015-06-11

申请号：US14412838

申请日：2013-07-04

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irun R. Cohen ,  Meir Shinitzky ,  Raanan Margalit ,  Michal Cohen-Sfady ,  Alexandra Zanin-Zhorov

IPC: A61K31/216

CPC classification number: A61K31/216

Abstract: The present invention relates to the compound amino-phenyl-acetic acid octadec-(Z)-9-enyl ester, an enantiomer thereof or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising it, for use in the treatment of tumors and metastases, and to methods for treating a tumor or metastases comprising administering said compound to a subject in need thereof. The present invention particularly relates to said compound when it is dissolved in an ethanol solution.

Abstract translation: 本发明涉及用于治疗肿瘤和转移的化合物氨基 - 苯基 - 乙酸十八 - （Z）-9-烯酯，其对映异构体或其药学上可接受的盐或包含它的药物组合物， 以及用于治疗肿瘤或转移的方法，包括向有需要的受试者施用所述化合物。 当本发明溶于乙醇溶液时，本发明特别涉及所述化合物。

公开(公告)号：US20140315740A1

公开(公告)日：2014-10-23

申请号：US14320530

申请日：2014-06-30

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Irun R. Cohen ,  Francisco Javier Quintana ,  Eytan Domany ,  Gad Elizur ,  Peter H. Hagedorn

IPC: G01N33/564

CPC classification number: G01N33/564

Abstract: A method of diagnosing an immune disease, or a predisposition thereto, in a subject is disclosed. The method comprises determining a capacity of immunoglobulins of the subject to specifically bind each antigen probe of an antigen probe set, wherein the antigen probe set comprises a plurality of antigen probes selected from the group consisting of at least a portion of a cell/tissue structure molecule, at least a portion of a heat shock protein, at least a portion of an immune system molecule, at least a portion of a homopolymeric polypeptide, at least a portion of a hormone, at least a portion of a metabolic enzyme, at least a portion of a microbial antigen, at least a portion of a molluscan antigen, at least a portion of a nucleic acid, at least a portion of a plant antigen, at least a portion of plasma molecule, and at least a portion of a tissue antigen, wherein the capacity is indicative of the immune disease or the predisposition thereto, thereby diagnosing the immune disease, or the predisposition thereto, in the subject.

Abstract translation: 公开了一种在受试者中诊断免疫疾病或其倾向的方法。 该方法包括确定受试者的免疫球蛋白的能力以特异性结合抗原探针组的每个抗原探针，其中所述抗原探针组包含多个选自下组的抗原探针：至少一部分细胞/组织结构 分子，至少一部分热休克蛋白，至少一部分免疫系统分子，至少一部分均聚多肽，至少一部分激素，代谢酶的至少一部分，至少 一部分微生物抗原，至少一部分软体动物素抗原，至少一部分核酸，至少一部分植物抗原，至少一部分血浆分子和至少一部分组织 抗原，其中所述能力指示免疫疾病或其易感性，从而诊断受试者的免疫疾病或其易感性。

公开(公告)号：US11846636B2

公开(公告)日：2023-12-19

申请号：US16751831

申请日：2020-01-24

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/53 ,  G01N33/564 ,  C12Q1/6883 ,  A61K31/711

CPC classification number: G01N33/564 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5308 ,  G01N2800/104

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US11047855B2

公开(公告)日：2021-06-29

申请号：US15555258

申请日：2016-02-29

Applicant: IMMUNARRAY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi ,  Pennina Safer ,  Anat Reiner-Benaim ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/68 ,  G16B40/00

Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

公开(公告)号：US10288622B2

公开(公告)日：2019-05-14

申请号：US14883685

申请日：2015-10-15

Applicant: Yeda Research and Development Co. Ltd. ,  Universitätsklinikum Hamburg-Eppendorf

Inventor： Eran Ovadia ,  Irun R. Cohen ,  Johannes Herkel ,  Raanan Margalit ,  Meirav Pevsner-Fischer

IPC: G01N33/53 ,  C12Q1/64 ,  G01N33/68 ,  A61K38/08 ,  A61K38/18 ,  A61K38/30 ,  A61K45/06 ,  A61K31/343 ,  C07K7/06 ,  G01N33/543

Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.

公开(公告)号：US20140200159A1

公开(公告)日：2014-07-17

申请号：US14210409

申请日：2014-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N33/6803 ,  G06F19/18 ,  G06F19/24

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

Abstract translation: 用于聚类的方法，系统和制品，从而鉴定与需要诊断疾病或监测治疗的患者受试者的血清的未确定免疫球蛋白反应的预定义抗原。

公开(公告)号：US11965885B2

公开(公告)日：2024-04-23

申请号：US17332178

申请日：2021-05-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Rachel Sorek ,  Keren Jakobi ,  Pennina Safer ,  Anat Reiner-Benaim ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/68 ,  G16B40/00 ,  G16B40/20

CPC classification number: G01N33/564 ,  G01N33/6854 ,  G16B40/20 ,  G01N2800/104 ,  G16B40/00

Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

公开(公告)号：US11480568B2

公开(公告)日：2022-10-25

申请号：US16133295

申请日：2018-09-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi-Brook ,  Pennina Safer ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/577

Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

公开(公告)号：US20140120126A1

公开(公告)日：2014-05-01

申请号：US14146549

申请日：2014-01-02

Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Bracha Rager-Zisman ,  Angel Porgador ,  Johannes Herkel

IPC: A61K47/48 ,  G01N33/569 ,  C07K14/005

CPC classification number: G01N33/56983 ,  A61K47/646 ,  A61K2039/6043 ,  A61K2039/64 ,  C07K14/005 ,  C12N2770/24122 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/53 ,  Y02A50/60

Abstract: The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.

Abstract translation: 本发明提供了包含分离的病毒抗原肽和衍生自HSP60的T细胞表位的合成肽的改进的疫苗。 本发明包括其中肽用作佐剂以及其中肽与病毒抗原共价连接的缀合物的混合物。 已知的合成肽载体p458为合成的病毒表位和类似物提供显着改善的免疫原性。 Ec27是从HSP60衍生的新型肽，其作为混合物或共价缀合物增加了病毒抗原的免疫原性。 一些分离的病毒表位是新的，并且被要求用于诊断以及治疗或预防用途。