公开(公告)号：US20070293440A1

公开(公告)日：2007-12-20

申请号：US11750600

申请日：2007-05-18

申请人： Virginia Smith-Swintosky ,  David McComsey ,  Michael Parker ,  Allen Reitz ,  Bruce Maryanoff

发明人： Virginia Smith-Swintosky ,  David McComsey ,  Michael Parker ,  Allen Reitz ,  Bruce Maryanoff

IPC分类号： A61K31/7008 ,  A61K31/5513 ,  A61K31/55 ,  A61K31/353 ,  A61K31/343 ,  A61K31/515 ,  A61K31/335 ,  A61K31/35 ,  A61K31/36 ,  A61K31/198

CPC分类号： A61K31/337 ,  A61K31/18 ,  A61K45/06 ,  C07D311/58 ,  C07D317/46 ,  C07D317/70 ,  C07D319/20 ,  C07D319/22 ,  C07D321/10 ,  A61K2300/00

摘要： The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.

摘要翻译： 本发明涉及用于治疗癫痫和相关病症的共同治疗，其包括向有需要的受试者施用治疗有效量的苯并稠合的杂环磺酰胺衍生物和治疗有效量的一种或多种 更多的抗惊厥药和/或抗癫痫剂。

公开(公告)号：US20060276528A1

公开(公告)日：2006-12-07

申请号：US11359626

申请日：2006-02-22

申请人： Ahmed Abdel-Magid ,  Bruce Maryanoff ,  Steven Mehrman ,  Michael Parker ,  Allen Reitz

发明人： Ahmed Abdel-Magid ,  Bruce Maryanoff ,  Steven Mehrman ,  Michael Parker ,  Allen Reitz

IPC分类号： A61K31/404 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/343 ,  C07D333/02

CPC分类号： C07D307/81 ,  C07D209/14 ,  C07D333/58 ,  C07D409/12

摘要： The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. The present invention is further directed to a crystalline form of N-(benzo[b]thien-3-ylmethyl)-sulfamide and a process for its preparation.

摘要翻译： 本发明涉及新颖的苯并稠合杂芳基磺酰胺衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。 本发明还涉及N-（苯并[b]噻吩-3-基甲基） - 磺酰胺的结晶形式及其制备方法。

公开(公告)号：US20050004136A1

公开(公告)日：2005-01-06

申请号：US10898130

申请日：2004-07-23

申请人： Kevin Pan ,  Michael Parker ,  Allen Reitz ,  Steven Coats ,  Cheryl Kordik ,  Chi Luo

发明人： Kevin Pan ,  Michael Parker ,  Allen Reitz ,  Steven Coats ,  Cheryl Kordik ,  Chi Luo

IPC分类号： C07D295/18 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61P1/08 ,  A61P17/04 ,  A61P25/00 ,  A61P25/06 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  C07D211/16 ,  C07D211/34 ,  C07D213/44 ,  C07D213/56 ,  C07D213/75 ,  C07D295/192 ,  C07D307/46 ,  C07D307/68 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14 ,  A61K31/497 ,  C07

CPC分类号： C07D213/75 ,  C07D211/16 ,  C07D213/44 ,  C07D295/192 ,  C07D307/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/14

摘要： Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives of the general formula wherein all variables are as described herein, useful in the treatment of disorders, such as depression, dementia, schizophrenia, bipolar disorders, anxiety, emesis, acute or neuropathic pain, itching, migraine and movement disorders.

摘要翻译： 新颖的通式的酰氨基烷基 - 哌啶和酰氨基烷基 - 哌嗪衍生物，其中所有变量如本文所述，可用于治疗疾病如抑郁症，痴呆，精神分裂症，双相情感障碍，焦虑，呕吐，急性或神经性疼痛，瘙痒， 偏头痛和运动障碍。

公开(公告)号：US20070155827A1

公开(公告)日：2007-07-05

申请号：US11612249

申请日：2006-12-18

申请人： Virginia Smith-Swintosky ,  Allen Reitz

发明人： Virginia Smith-Swintosky ,  Allen Reitz

IPC分类号： A61K31/36 ,  A61K31/353

CPC分类号： A61K31/353 ,  A61K31/352 ,  A61K31/357

摘要： The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.

摘要翻译： 本发明是一种治疗抑郁症的方法，包括向有需要的受试者施用治疗有效量的如本文所定义的一种或多种式（I）和式（II）的新型苯并稠合的杂环磺酰胺衍生物。 本发明涉及一种治疗抑郁症的方法，其包括单一治疗，或者与至少一种抗抑郁药共同治疗。

公开(公告)号：US20050004154A1

公开(公告)日：2005-01-06

申请号：US10909858

申请日：2004-08-02

申请人： Alfonzo Jordan ,  Allen Reitz ,  Kevin Pan

发明人： Alfonzo Jordan ,  Allen Reitz ,  Kevin Pan

IPC分类号： A61K31/438 ,  A61P11/06 ,  A61P11/14 ,  A61P25/00 ,  A61P25/06 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D471/10 ,  A61K31/4747

CPC分类号： C07D471/10

摘要： The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.

摘要翻译： 本发明涉及通式的新的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物，其中所有变量如本文所定义，可用于治疗ORL-1 G介导的病症和病症 蛋白偶联受体。 更具体地，本发明的化合物可用于治疗诸如焦虑，抑郁，药物滥用，神经性疼痛，急性疼痛，偏头痛，哮喘，咳嗽和改善认知的病症和病症。

公开(公告)号：US5382580A

公开(公告)日：1995-01-17

申请号：US250484

申请日：1994-05-27

申请人： Robert Chen ,  Michael G. Goodman ,  Allen Reitz

发明人： Robert Chen ,  Michael G. Goodman ,  Allen Reitz

IPC分类号： C07D473/18 ,  A61K31/535

CPC分类号： C07D473/18

摘要： Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.

摘要翻译： 公开了其还含有吗啉基作为位置-9取代基的7,8-二取代的鸟嘌呤衍生物，其结构由式I其中X是O或S表示; R1是长度为约1至约7个碳原子的烃基或取代的烃基; R2是氢或C1-C8酰基; R3是氢，C1-C5脂族烃基，芳烷基或取代的芳烷基; 及其药学上可接受的碱加成盐。 还公开了含有免疫刺激性取代的鸟嘌呤衍生物的组合物及其使用方法。

公开(公告)号：US20080070919A1

公开(公告)日：2008-03-20

申请号：US11750629

申请日：2007-05-18

申请人： Christopher Creighton ,  Tina Ross ,  Allen Reitz ,  Cheryl Kordik ,  Steven Paget ,  Gregor MacDonald

发明人： Christopher Creighton ,  Tina Ross ,  Allen Reitz ,  Cheryl Kordik ,  Steven Paget ,  Gregor MacDonald

IPC分类号： A61K31/50 ,  C07D241/36

CPC分类号： C07D487/08

摘要： The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The compounds of the present invention are serotonin transport inhibitors and/or modulators of 5HT1A.

摘要翻译： 本发明涉及桥连芳基哌嗪衍生物，含有它们的药物组合物及其在治疗抑郁症和相关疾病中的用途。 本发明的化合物是5-羟色胺转运抑制剂和/或5HT 1A调节剂。

公开(公告)号：US20070232642A1

公开(公告)日：2007-10-04

申请号：US11671703

申请日：2007-02-06

申请人： Ellen Baxter ,  Allen Reitz ,  Christopher Crieghton

发明人： Ellen Baxter ,  Allen Reitz ,  Christopher Crieghton

IPC分类号： A61K31/44 ,  A61P25/28 ,  C07D215/38

CPC分类号： C07D413/14 ,  C07D215/38 ,  C07D403/12 ,  C07D405/06 ,  C07D405/14

摘要： The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

摘要翻译： 本发明涉及2-氨基-3,4-二氢喹啉衍生物，含有它们的药物组合物及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。 本发明的化合物是β-分泌酶的抑制剂，也称为β-位点切割酶和BACE，BACE1，Asp2和memapsin2。

公开(公告)号：US20060079686A1

公开(公告)日：2006-04-13

申请号：US11197608

申请日：2005-08-04

申请人： Ellen Baxter ,  Robert Boyd ,  Steven Coats ,  Alfonzo Jordan ,  Allen Reitz ,  Charles Reynolds ,  Malcolm Scott

发明人： Ellen Baxter ,  Robert Boyd ,  Steven Coats ,  Alfonzo Jordan ,  Allen Reitz ,  Charles Reynolds ,  Malcolm Scott

IPC分类号： C07D403/02 ,  C07D239/84

CPC分类号： C07D215/227 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/06

摘要： The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

公开(公告)号：US20060030604A1

公开(公告)日：2006-02-09

申请号：US11236097

申请日：2005-09-27

申请人： Magdalena Elsinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Elsinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

IPC分类号： C07D285/08 ,  A61K31/433

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.