公开(公告)号：US07605272B2

公开(公告)日：2009-10-20

申请号：US11814753

申请日：2006-01-27

申请人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

发明人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

IPC分类号： C07D231/56 ,  C07D211/06 ,  C07D413/10 ,  C07D403/10 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/5377

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  C07D495/04

摘要： The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(═O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

摘要翻译： 本发明提供一种I型胰岛素样生长因子受体（IGF-1R）抑制剂，其包含作为活性成分的由式（I）表示的吲唑衍生物：其中R 1表示-NR 4 R 5 [其中R 4表示氢原子或 R 5表示取代或未取代的低级烷基，-C（-O）R 6（其中R 6表示取代或未取代的低级烷基，取代或未取代的芳基等），R 2和R 3可以相同 或不同的，并且各自表示氢原子，羟基，取代或未取代的低级烷氧基等}或其药学上可接受的盐等。

公开(公告)号：US20070117856A1

公开(公告)日：2007-05-24

申请号：US10548475

申请日：2004-07-30

申请人： Yoshihisa Ohta ,  Fumihiko Kanai ,  Shinji Nara ,  Yutaka Kanda ,  Hiroshi Umehara ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi ,  Keiko Kawashima ,  Hiromi Ando ,  Motoki Miyama

发明人： Yoshihisa Ohta ,  Fumihiko Kanai ,  Shinji Nara ,  Yutaka Kanda ,  Hiroshi Umehara ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi ,  Keiko Kawashima ,  Hiromi Ando ,  Motoki Miyama

IPC分类号： A61K31/416 ,  C07D231/56

CPC分类号： C07D231/56

摘要： The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

摘要翻译： 本发明提供由式（I）表示的化合物：[其中R 1表示CONR 1a 1b 1b（其中R 1a） R 1b和R 1b可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基， 或R 1a和R 1b与相邻的氮原子一起形成取代或未取代的杂环基）等，R 2 O， >表示氢原子，其中R 2a，R 2b和R 2b可以相同或不同， 各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基，或R 2b和R 2b >与t结合在一起 它与氮原子相邻以形成取代或未取代的杂环基），NR 2c R 2d（其中R 2c和R 2d） 取代或未取代的低级烷酰基，取代或未取代的芳酰基，取代或未取代的杂芳酰基，取代或未取代的芳烷基，取代或未取代的低级烷基磺酰基或 取代或未取代的低级芳基磺酰基等）。

公开(公告)号：US06698202B2

公开(公告)日：2004-03-02

申请号：US10084261

申请日：2002-02-26

申请人： Takato Ogiwara ,  Kenji Sano ,  Naganori Koshimizu ,  Hiromi Ando

发明人： Takato Ogiwara ,  Kenji Sano ,  Naganori Koshimizu ,  Hiromi Ando

IPC分类号： B60T11224

CPC分类号： B60T11/224 ,  B60T11/26

摘要： A master cylinder of the invention supplies a brake fluid from a large diameter pressurizing chamber 56 to a small diameter hydraulic chamber 49 by opening a reverse flow checking opening and closing portion 61 by sliding movement of a stepped piston 16 forwardly, that is, fast fill and when the hydraulic pressure of the large diameter pressurizing chamber 56 rises, a control valve 86 escapes the hydraulic pressure of the large diameter pressurizing chamber 56 to a reservoir 12 to gradually lower in accordance with rise of the hydraulic pressure of the small diameter hydraulic chamber 49, thereby capable of reducing a strange feeling in a pedal feeling caused by sudden pressure release of the large diameter pressuring chamber 56.

摘要翻译： 本发明的主缸通过向前倾斜阶梯式活塞16的滑动打开反向流动检查开闭部61来将制动液从大直径加压室56供给到小直径液压室49，即快速填充 并且当大直径加压室56的液压上升时，控制阀86将大直径加压室56的液压从储存器12排出，以便随着小直径液压室的液压升高逐渐降低 从而能够减小由大直径加压室56的突然的压力释放引起的踏板感觉的奇怪的感觉。

公开(公告)号：US06625981B2

公开(公告)日：2003-09-30

申请号：US10050100

申请日：2002-01-18

申请人： Junichi Ikeda ,  Hiromi Ando ,  Atsuya Koshu

发明人： Junichi Ikeda ,  Hiromi Ando ,  Atsuya Koshu

IPC分类号： F16D3102

CPC分类号： F02M35/10229 ,  B60T13/52 ,  F02M35/10

摘要： There is disclosed a pneumatic booster having a vacuum chamber connected to an intake pipe of an engine. An air outlet of an ejector is connected to the intake pipe through a vacuum control valve, and an air inlet of the ejector is connected to an air cleaner. A vacuum pick-up port of the ejector is connected to the vacuum chamber of a booster body. The vacuum control valve comprises a control chamber and a control piston, and the negative pressure in the booster is introduced into the control chamber and acts on the control piston. When the negative pressure in the booster is insufficient, the control piston acts to open the control valve and a negative pressure is supplied from the ejector to the vacuum chamber. When the negative pressure in the booster is sufficiently high, the control piston acts to close the control valve and stops the operation of the ejector, thus reducing an effect of the ejector with respect to an air/fuel ratio of the engine.

公开(公告)号：US5884548A

公开(公告)日：1999-03-23

申请号：US831143

申请日：1997-04-01

申请人： Hiromi Ando ,  Kiyoshi Shirahata ,  Mitsuhiro Endo ,  Atsuya Koshu

发明人： Hiromi Ando ,  Kiyoshi Shirahata ,  Mitsuhiro Endo ,  Atsuya Koshu

IPC分类号： B60T8/32 ,  B60T13/563 ,  F15B9/10

CPC分类号： B60T13/563 ,  B60T8/3275

摘要： A brake booster includes a housing, a partition adapted to divide the interior of the housing into two chambers, and two diaphragms adapted to divide the two chambers into constant and variable pressure chambers. A control valve includes a valve body carried by the diaphragms, and a plunger slidably received in the valve body. The control valve is operatively connected to the variable pressure chambers to develop a pressure differential across the diaphragms to cause the diaphragms to move in response to actuation of an input rod. A reaction disk is disposed between an output rod and the valve body to transmit the reaction of movement of the output rod to the input rod. An adjusting mechanism is disposed between the plunger and the reaction disk and compressible so as to develop a greater degree of pressure differential when a force applied by the input rod exceeds a predetermined level. The reaction disk is caused to make contact with the contact disk and held out of contact with the spring and the plunger when the plunger is actuated.

摘要翻译： 制动助力器包括壳体，适于将壳体的内部分成两个腔室的隔板以及适于将两个腔室分成恒定和可变压力腔室的两个隔膜。 控制阀包括由隔膜承载的阀体和可滑动地容纳在阀体中的柱塞。 控制阀可操作地连接到可变压力室，以跨越隔膜形成压力差，以响应于输入杆的致动而使隔膜移动。 反作用盘设置在输出杆和阀体之间，以将输出杆的运动反应传递到输入杆。 调节机构设置在柱塞和反作用盘之间并且可压缩，以便当由输入杆施加的力超过预定水平时产生更大程度的压力差。 当活塞被致动时，使反作用盘与接触盘接触并与弹簧和柱塞保持不接触。

公开(公告)号：US5312175A

公开(公告)日：1994-05-17

申请号：US904988

申请日：1992-06-26

申请人： Hiromi Ando ,  Kunihiro Matsunaga ,  Kenji Sano ,  Satoru Suga

发明人： Hiromi Ando ,  Kunihiro Matsunaga ,  Kenji Sano ,  Satoru Suga

IPC分类号： B60T8/34 ,  B60T8/40 ,  B60T8/42 ,  B60T8/50 ,  B60T13/18

CPC分类号： B60T8/4054 ,  B60T8/341 ,  B60T8/4291 ,  B60T8/5037 ,  Y10S303/90

摘要： The present invention relates to a brake fluid pressure control apparatus in which a casing contains a pump communication port separately from a master cylinder communication port. A spool is also provided which limits the communication between the pump communication port and the master cylinder communication port in a manner such that the discharge pressure from the pump is not added directly to the master cylinder. Additionally, in the intake and discharge sides of the pump, a bypass channel is provided. In this bypass channel, a relief valve is provided which allows the escape of pressure force to the intake side of the pump in the case when the pressure force between the discharge side of the pump and the flow control increases to a high pressure. Furthermore, because the brake fluid is normally designed to be discharged from the pump to the flow control valve at approximately a fixed flow rate by means of the relief valve, there is no return of brake fluid to the master cylinder via the flow control valve, and stroke fluctuations of the master cylinder can be eliminated. Additionally, the necessity for providing an orifice between a pump communication port and the master cylinder communication port disappears.

摘要翻译： 制动液压控制装置技术领域本发明涉及一种制动液压控制装置，其中壳体包含与主缸连通口分开的泵连通口。 还提供了一种阀芯，其以使得来自泵的排出压力不直接添加到主缸的方式限制泵通信端口和主缸连通端口之间的连通。 此外，在泵的吸入侧和排出侧设置有旁通通道。 在该旁路通道中，设置有安全阀，当在泵的排出侧和流量控制之间的压力增加到高压的情况下，提供压力力到泵的吸入侧的泄压阀。 此外，由于制动液通常被设计为通过安全阀以大致固定的流量从泵排出到流量控制阀，所以不会通过流量控制阀将制动流体返回到主缸， 可以消除主缸的冲程波动。 此外，在泵通信端口和主缸通信端口之间提供孔口的必要性消失。

公开(公告)号：US4245845A

公开(公告)日：1981-01-20

申请号：US860322

申请日：1977-12-14

申请人： Hiromi Ando ,  Tomizo Azuma

发明人： Hiromi Ando ,  Tomizo Azuma

IPC分类号： B60T13/569 ,  F16J15/12

CPC分类号： B60T13/569

摘要： A vacuum booster device having a diaphragm the inner peripheral portion of which is rigidly clamped between the outer peripheral portion of a valve body and the central portion of a piston plate, wherein a rigid annular ring is attached to the diaphragm for preventing the radial outward movement of the material of the inner peripheral portion of the diaphragm when the diaphragm is compressed axially between the valve body and the piston plate.

摘要翻译： 一种真空增压装置，其具有其内周部刚性地夹紧在阀体的外周部分与活塞板的中心部分之间的隔膜，其中刚性环形环安装在隔膜上以防止径向向外移动 当隔膜在阀体和活塞板之间轴向压缩时，隔膜的内周部分的材料。

公开(公告)号：US06578360B2

公开(公告)日：2003-06-17

申请号：US09984794

申请日：2001-10-31

申请人： Tomonori Mouri ,  Takato Ogiwara ,  Hiromi Ando ,  Naganori Koshimizu

发明人： Tomonori Mouri ,  Takato Ogiwara ,  Hiromi Ando ,  Naganori Koshimizu

IPC分类号： B60T1120

CPC分类号： B60T11/20

摘要： A master cylinder including a cylinder having one end open to the outside. A secondary piston guide ring, a sleeve and a primary piston guide ring are adapted to be fitted in this order into the cylinder from the one open end. A piston is slidably fitted in an axial direction of the cylinder, into each of the secondary piston guide ring, the sleeve and the primary piston guide ring. A retainer is provided at the open end of the cylinder, and adapted to abut against the primary piston guide ring so as to prevent escape of the primary piston guide ring from the cylinder. An elastic member is provided between a rearward end portion of the sleeve and a forward end portion of the primary piston guide ring.

摘要翻译： 主缸，其具有一端向外敞开的气缸。 次级活塞导向环，套筒和主活塞导向环适于从一个开口端顺次安装到气缸中。 活塞在气缸的轴向方向可滑动地装配到每个次级活塞导向环，套筒和主活塞导向环中。 保持器设置在气缸的开口端处，并且适于抵靠主活塞导向环，以防止主活塞导向环从气缸逸出。 弹性构件设置在套筒的后端部和主活塞导向环的前端部之间。

公开(公告)号：US5743167A

公开(公告)日：1998-04-28

申请号：US715894

申请日：1996-09-19

申请人： Shuzo Watanabe ,  Mitsuhiro Endo ,  Hiromi Ando

发明人： Shuzo Watanabe ,  Mitsuhiro Endo ,  Hiromi Ando

IPC分类号： B60T13/563 ,  B60T13/567 ,  B60T13/569 ,  F01B19/00 ,  F15B11/00

CPC分类号： B60T13/567 ,  B60T13/563 ,  B60T13/569

摘要： A tandem pneumatic booster having a shell body, the inside of which is divided into two, front and rear, chambers by a center shell. Each chamber includes a negative pressure chamber and a working pressure chamber. A valve body is slidably fitted in the shell body and the center shell with seal members therebetween. The valve body is provided with an air passage for communication between the front and rear working pressure chambers. A valve mechanism is actuated in association with an input shaft to introduce atmospheric air into the front and rear working pressure chambers through the air passage so as to apply thrust to front and rear power pistons. The diaphragm of the front power piston has a bead on an inner periphery thereof. The valve body has a groove on an outer periphery thereof. A portion of the air passage which leads to the front working pressure chamber has a main passage portion extending axially in the valve body, and a bypass extending radially outward from the main passage portion. A communicating port leading to the front working pressure chamber extends axially from the bypass. The bypass opens into the groove, and the radially outer end of the bypass is sealed with the bead.

摘要翻译： 一种串联式气动助力器，其具有壳体，其壳体通过中心壳体分成两个，前后腔。 每个室包括负压室和工作压力室。 阀体可滑动地装配在壳体和中心壳体之间，其间具有密封构件。 阀体设置有用于在前后工作压力室之间连通的空气通道。 阀门机构与输入轴相关联地致动，以将空气通过空气通道引入前后工作压力室，从而将推力施加到前后动力活塞。 前功率活塞的隔膜在其内周上具有凸缘。 阀体的外周具有槽。 通向前工作压力室的空气通道的一部分具有在阀体中轴向延伸的主通道部分和从主通道部分径向向外延伸的旁路。 通向前工作压力室的连通口从旁路轴向延伸。 旁路通向槽中，旁路的径向外端用珠密封。

公开(公告)号：US5526729A

公开(公告)日：1996-06-18

申请号：US164051

申请日：1993-12-08

申请人： Hiromi Ando ,  Nobumaro Osaka ,  Yasuhiko Amari

发明人： Hiromi Ando ,  Nobumaro Osaka ,  Yasuhiko Amari

IPC分类号： B60T13/44 ,  B60T13/52 ,  F15B13/04

CPC分类号： B60T13/44 ,  B60T13/52

摘要： The present invention provides a booster of the gaseous pressure type. The booster of the gaseous pressure type comprises: a power piston dividing the inside of a shell between a constant pressure chamber the inside of which is maintained in an approximately constant pressure, and a variable pressure chamber into which an operation gas can be introduced, wherein the power piston comprises a valve body projecting to the outside of the shell and a movable partition means for dividing the inside of the shell, with the inner periphery of the partition means fixed to the valve body; a valve for introducing the operation gas into the variable pressure chamber through a communication passage, according to a movement relative to the valve body of an input shaft which is connected to a brake pedal, and provided in the valve body; a cover for supporting the valve body and for forming an operation gas chamber which can store the operation gas, together with the shell, provided outside the portion of the valve body projecting from the shell; a gas source generating the operation gas; and a path for supplying the operation gas from the gas source to the operation gas chamber.

摘要翻译： 本发明提供一种气压式增压器。 气压式助力器包括：动力活塞，其将壳体内部分隔在保持在近似恒定压力的恒定压力室之间，以及可变压力室，操作气体可以引入到其中，其中 动力活塞包括突出到壳体外部的阀体和用于分隔壳体内部的可移动分隔装置，分隔装置的内周固定到阀体上; 根据连接到制动踏板的输入轴的阀体的运动并设置在阀体中的通过连通路将工作气体导入到可变压力室中的阀; 用于支撑阀体和用于形成操作气体室的盖，该操作气体室与外壳一起存储设置在从壳体突出的阀体的外部的外部; 产生操作气体的气体源; 以及用于将气体源的操作气体供给到操作气体室的路径。