公开(公告)号：US3939042A

公开(公告)日：1976-02-17

申请号：US495272

申请日：1974-08-06

申请人： Kiyoshi Nakayama ,  Mamoru Kobata ,  Yoshitake Tanaka ,  Tadaaki Nomura ,  Ryoichi Katsumata

发明人： Kiyoshi Nakayama ,  Mamoru Kobata ,  Yoshitake Tanaka ,  Tadaaki Nomura ,  Ryoichi Katsumata

IPC分类号： C12P13/14 ,  C12D13/06 ,  C12K1/02

CPC分类号： C12P13/14 ,  Y10S435/822 ,  Y10S435/874

摘要： High yields of L-glutamic acid are produced by culturing mutant strains of microorganisms of the genera Pseudomonas and Protaminobacter in a culture medium containing methanol as the principal source of assimilable carbon. L-glutamic acid is accumulated in the culture liquor and is isolated therefrom.

摘要翻译： 通过在含有甲醇作为可同化碳的主要来源的培养基中培养假单胞菌属和Protaminobacter属的微生物的突变菌株来产生高产量的L-谷氨酸。 L-谷氨酸在培养液中积聚并从其中分离出来。

公开(公告)号：US08309546B2

公开(公告)日：2012-11-13

申请号：US13308239

申请日：2011-11-30

申请人： Kiyoshi Nakayama ,  Kazuyuki Sugita ,  Masaki Setoguchi ,  Yuichi Tominaga ,  Masanori Saitou ,  Takashi Odagiri

发明人： Kiyoshi Nakayama ,  Kazuyuki Sugita ,  Masaki Setoguchi ,  Yuichi Tominaga ,  Masanori Saitou ,  Takashi Odagiri

IPC分类号： A61K31/535 ,  C07D413/14

CPC分类号： C07D473/34

摘要： There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.

摘要翻译： 提供抑制磷脂酰肌醇3-激酶（PI3K）和/或雷帕霉素（mTOR）的哺乳动物靶标并表现出抗肿瘤活性的新型化合物。 本发明提供具有抑制PI3K和/或mTOR的各种取代基并表现出抗肿瘤活性的下述式（1）表示的化合物：其中R1，R2，R3，R4，Ra，Rb，Rc和X各自具有 与本说明书中定义的含义相同。

公开(公告)号：US20120108582A1

公开(公告)日：2012-05-03

申请号：US12459612

申请日：2009-07-02

申请人： Hisashi Takahashi ,  Satoshi Komoriya ,  Takahiro Kitamura ,  Takashi Odagiri ,  Hiroaki Inagaki ,  Toshifumi Tsuda ,  Kiyoshi Nakayama ,  Makoto Takemura ,  Kenichi Yoshida ,  Rie Miyauchi ,  Masatoshi Nagamochi

发明人： Hisashi Takahashi ,  Satoshi Komoriya ,  Takahiro Kitamura ,  Takashi Odagiri ,  Hiroaki Inagaki ,  Toshifumi Tsuda ,  Kiyoshi Nakayama ,  Makoto Takemura ,  Kenichi Yoshida ,  Rie Miyauchi ,  Masatoshi Nagamochi

IPC分类号： A61K31/4709 ,  C07D498/06 ,  A61K31/5383 ,  A61P1/12 ,  A61P29/00 ,  A61P31/04 ,  A61P31/00 ,  A61P33/00 ,  A61P17/00 ,  A61P15/00 ,  A61P17/10 ,  A61P11/08 ,  A61P11/00 ,  A61P13/08 ,  A61P13/02 ,  A61P27/02 ,  A61P1/02 ,  A61P37/00 ,  A61P31/06 ,  A61P31/08 ,  C07D401/10

CPC分类号： C07D498/06 ,  C07D209/02 ,  C07D209/56 ,  C07D401/04 ,  C07D401/14 ,  C07D491/048 ,  C07D491/052 ,  Y02P20/55

摘要： A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

摘要翻译： 提供了作为药物具有优异性能的喹诺酮合成抗菌剂，其不仅对革兰氏阴性菌具有很强的抗菌活性，而且对喹诺酮类抗菌剂具有低敏感性的革兰氏阳性球菌具有很强的抗菌活性，并且其表现出高安全性和优异的药代动力学 。 由式（I）表示的化合物或其盐或其水合物。 具体地，其中取代基R6和R7与它们所键合的碳原子一起形成式（I）的喹诺酮衍生物形成可以含有氧原子作为环组成原子的环状结构，所述环状结构形成5- 4,5,5-或5-6稠合双环吡咯烷基取代基，该取代基与含有吡啶并苯并恶嗪结构的喹诺酮母体骨架Q结合。

公开(公告)号：US20050009843A1

公开(公告)日：2005-01-13

申请号：US10475091

申请日：2002-04-24

申请人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  Ryo Okumura ,  Kazuki Hoshino ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

发明人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  Ryo Okumura ,  Kazuki Hoshino ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

IPC分类号： A61K31/427 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  A61P31/00 ,  A61P31/04 ,  A61P43/00 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C12Q1/18

CPC分类号： C07D417/06 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  C07D471/04 ,  C12Q1/18

摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)—(R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

摘要翻译： 一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2表示氢原子，卤素原子， 羟基等，W 1表示-CH = CH-，-CH 2 O - ， - CH 2 CH 2 - 等; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZ 0 -4 R 5基团（Z 0-4表示亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基， 芳基等）; W 2表示单键或-C（R 8）= C（R 9） - （R 8和R 9）表示氢原子，卤素原子，低级烷基或 Q表示酸性基团，但W 2和Q可以一起形成亚乙烯基二胺或等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。

公开(公告)号：US06463968B1

公开(公告)日：2002-10-15

申请号：US09762543

申请日：2001-02-09

申请人： Eiji Hattori ,  Masaaki Murase ,  Kiyoshi Nakayama ,  Osamu Yazaki

发明人： Eiji Hattori ,  Masaaki Murase ,  Kiyoshi Nakayama ,  Osamu Yazaki

IPC分类号： B65D714

CPC分类号： B65B43/54 ,  B65B3/16 ,  B65B3/17 ,  B65B5/106 ,  B65B7/14 ,  B65B19/34 ,  B65B39/12 ,  B65B43/46

摘要： The present invention is a system for filling a container main body at least whose drum body is made of a flexible film, with a viscous material. A viscous material is charged by the charging means into container main bodies conveyed by the container conveying means, the drum body of the container main body is pressed by the pressing means to cause the surface of the viscous material to bulge, and the opening of the reinforcing component of the container main body is capped by the capping means, allowing the opening to be capped in an air-tight manner with a lid member while virtually all of the air inside the container main body is evacuated, and preventing air from being left over in the container main body so as to prevent hardening, curing and deterioration in the quality of the viscous material that can be caused by such remaining air.

摘要翻译： 本发明是一种用粘性材料填充容器主体至少其鼓体由柔性膜制成的系统。 通过充电装置将粘性材料装入由容器输送装置输送的容器主体中，容器主体的鼓体被加压装置按压使粘性材料的表面膨胀，并且打开 容器主体的增强部件被封盖装置盖住，允许开口用盖部件以气密方式被盖住，同时几乎所有的容器主体内的所有空气都被抽真空，并且防止空气被留下 在容器主体中，以防止由这种剩余空气引起的粘性物质的硬化，固化和劣化。

公开(公告)号：US6155539A

公开(公告)日：2000-12-05

申请号：US91969

申请日：1998-06-26

申请人： Kiyoshi Nakayama

发明人： Kiyoshi Nakayama

IPC分类号： E04H17/16

CPC分类号： E04H17/161

摘要： A fence and a furring strip for fence, which are light in weight and strong and are resistant to snow and wind are provided. Bent wire rods 1 are bent in a triangle shape, at the top 10 of which, at the portion a little off-center, a pair of parallel wire rods 2 are mounted both on the front and the rear sides. The furring strip in such a construction is inserted between vertical wire rods 51, 51 of the fence body formed like a folding screen. The furring strip is fixed on the fence body by an appropriate fitting and forms a fence.

摘要翻译： PCT No.PCT / JP96 / 03245 Sec。 371日期：1998年6月26日 102（e）日期1998年6月26日PCT 1996年11月6日PCT公布。 公开号WO97 / 26431 日期1997年7月24日提供了一个围栏和一个篱笆条，重量轻，坚固耐雨雪。 弯曲线材1弯曲成三角形，其顶部10在稍微偏心的部分处，一对平行的线材2都安装在前侧和后侧。 这种结构的带状条插入栅栏体的垂直线杆51,51之间，形成为折叠屏。 通过适当的配件将毛条固定在篱笆上，形成围栏。

公开(公告)号：US5599813A

公开(公告)日：1997-02-04

申请号：US221577

申请日：1994-04-01

申请人： Hiroo Matsumoto ,  Noriko Tanaka ,  Kiyoshi Nakayama ,  Haruko Chatani ,  Michio Iwahana

发明人： Hiroo Matsumoto ,  Noriko Tanaka ,  Kiyoshi Nakayama ,  Haruko Chatani ,  Michio Iwahana

IPC分类号： C07D513/04 ,  A61K31/55 ,  A61K31/505

CPC分类号： C07D513/04

摘要： Thiazolopyrimidine derivatives represented by the formula ##STR1## and salts thereof are provided, which are characterized by a carboxamide residue substituted with R.sup.4 and R.sup.5. The derivatives and salts thereof exhibit antiangiogenic activity and are useful for treatment and cure of diseases, the development of which may be related to angiogenesis, including diabetic retinopathy, various chronic inflammation conditions, growth or metastasis of malignant solid tumors, rheumatism and psoriasis.

摘要翻译： 提供由式＆lt; IMAGE＆gt;表示的噻唑并嘧啶衍生物及其盐，其特征在于被R4和R5取代的酰胺基。 其衍生物和盐显示抗血管生成活性，并且可用于治疗和治愈疾病，其发展可能与血管生成有关，包括糖尿病性视网膜病变，各种慢性炎症病症，恶性实体瘤的生长或转移，风湿病和牛皮癣。

公开(公告)号：US5057367A

公开(公告)日：1991-10-15

申请号：US475179

申请日：1990-02-05

申请人： Akira Morii ,  Shunichi Fujimura ,  Kiyoshi Nakayama

发明人： Akira Morii ,  Shunichi Fujimura ,  Kiyoshi Nakayama

IPC分类号： C08K3/20 ,  C08K3/16 ,  C08K3/22 ,  C08K3/24 ,  C08K3/26 ,  C08K9/04 ,  C09K21/02 ,  C09K21/14

CPC分类号： C08K3/22 ,  C08K3/26 ,  C09K21/02 ,  C09K21/14 ,  Y10T428/2958

摘要： A flame retardant comprising a mixture of 10 to 90% by weight of powder A and 90 to 10% by weight of powder B of magnesium hydroxide, the powder A containing 40 to 70% by weight of a powdered double salt of magnesium carbonate and calcium carbonate and 60 to 30% by weight of powdered basic magnesium carbonate; and a flame-retardant resin composition comprising 100 parts by weight of a thermoplastic resin and 30 to 300 parts by weight of the flame retardant. Preferably, the double salt is huntite, and the basic magnesium carbonate consists essentially of hydromagnesite. It is preferred to treat the flame retardant, in the form of a powder mixture, with a surface treatment agent. The flame-retardant resin composition is adapted for use as a sheath or insulation for an electric wire or cable, a fire-arresting material, or a wall material.

公开(公告)号：US4975547A

公开(公告)日：1990-12-04

申请号：US360784

申请日：1989-06-02

申请人： Kiyoshi Nakayama ,  Toshio Yoshioka ,  Kiyotaka Yamaguchi

发明人： Kiyoshi Nakayama ,  Toshio Yoshioka ,  Kiyotaka Yamaguchi

IPC分类号： B60R1/07 ,  B60R16/02 ,  H01H9/16 ,  H01H25/04

CPC分类号： B60R1/07 ,  H01H25/041 ,  H01H9/161 ,  H01H2300/012

摘要： The multi-position electrical switch includes a printed circuit (PC) board arranged in a casing and supporting an array of stationary contacts encircling a light emitting element fixed on the PC board. A resilient rubber sheet covers the PC board and supports an array of movable contacts arranged opposite the stationary contacts. A control knob having a central opening rests on the rubber sheet in the region of the movable contacts. The bottom of the knob is formed with a tubular projection communicating with the central opening of the knob and extending to the level of an opening in the rubber sheet around the light emitting element. The bottom of the knob is provided with four pin-shaped stoppers which delimit the tilting movement of the knob in four directions and the pressing surface portions of the bottom are inclined such as to evenly engage a depressed region of the rubber sheet when the knob is tilted in one of the four directions and the corresponding movable contacts are lowered and pressed against the opposite stationary contacts. The annular end face of the tubular projection has four inclined sections oriented according to the four tilting directions. In a tilted position of the knob, a corresponding inclined section fully engages the flat surface of the PC board thus safeguarding the actuation of the selected contacts only.

摘要翻译： 多位置电气开关包括布置在壳体中的印刷电路板（PC）板，并且支撑环绕固定在PC板上的发光元件的固定触点阵列。 弹性橡胶片覆盖PC板并且支撑布置成与固定触点相对布置的可动触点阵列。 具有中心开口的控制旋钮支撑在可移动触点的区域中的橡胶片上。 旋钮的底部形成有与旋钮的中心开口连通并且延伸到围绕发光元件的橡胶片中的开口的水平面的管状突起。 旋钮的底部设置有四个销状止动器，其限制了四个方向上的旋钮的倾斜运动，并且底部的按压表面部分是倾斜的，以便当该旋钮是旋钮时均匀地接合橡胶片的凹陷区域 在四个方向中的一个方向上倾斜，并且相应的可动触头下降并压靠在相对的固定触点上。 管状突起的环形端面具有根据四个倾斜方向定向的四个倾斜部分。 在旋钮的倾斜位置，相应的倾斜部分完全接合PC板的平坦表面，从而仅保护所选择的触点的致动。

公开(公告)号：US4732017A

公开(公告)日：1988-03-22

申请号：US945890

申请日：1986-12-24

申请人： Kiyoshi Nakayama

发明人： Kiyoshi Nakayama

IPC分类号： D06B5/18 ,  D06B5/12 ,  D06B5/22

CPC分类号： D06B5/12

摘要： An apparatus for treating textile materials has an impeller or vane wheel which is disposed in a flow passageway communicating with a circulatory pump and with the interior of a perforated cylindrical beam and which is connected to a shaft of the beam.

摘要翻译： 用于处理纺织材料的设备具有叶轮或叶轮，该叶轮或叶轮设置在与循环泵连通的流动通道中，并且与穿孔的圆柱形梁的内部连接并连接到梁的轴。