公开(公告)号：US08358407B2

公开(公告)日：2013-01-22

申请号：US12771753

申请日：2010-04-30

Applicant: Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/40

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: An integrated device for enhancing signals in Surface Enhanced Raman Spectroscopy (SERS). The integrated device comprising an array of nanostructures comprising a material, wherein the material is configured to allow light to pass through. The integrated device also comprising SERS active nanoparticles disposed on at least portion of the array of nanostructures and a mirror integrated below a base of the array of nanostructures. The mirror is configured to reflect light passing through the material into the array of nanostructures.

Abstract translation: 一种用于增强表面增强拉曼光谱（SERS）信号的集成器件。 所述集成器件包括纳米结构的阵列，其包括材料，其中所述材料被配置为允许光通过。 该集成装置还包括设置在纳米结构阵列的至少一部分上的SERS活性纳米颗粒和集成在纳米结构阵列的基底下方的反射镜。 镜子被配置为将通过材料的光反射到纳米结构阵列中。

公开(公告)号：US08330951B2

公开(公告)日：2012-12-11

申请号：US11413516

申请日：2006-04-28

Applicant: Zhiyong Li ,  William M. Tong ,  R. Stanley Williams

Inventor： Zhiyong Li ,  William M. Tong ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N33/00 ,  G01N21/62 ,  H01J9/12

CPC classification number: G01N21/658 ,  Y10T428/218 ,  Y10T428/28

Abstract: Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.

Abstract translation: 公开了封装的NERS-活性结构，其包括其上具有NERS-活性结构的NERS衬底和在NERS衬底上的具有穿过其中的开口的封装衬底，该开口与NERS-活性结构对准。 膜可以覆盖封装衬底中的开口。 为了进行纳米增强拉曼光谱，可以去除膜，并将分析物放置在邻近NERS-活性结构的NERS衬底上。 在将分析物放置在基底上之后，膜可以用另一膜替代。 膜可以在其被部署之前保持基材的原始状态，并且替换膜可以保留底物和分析物用于归档目的。 还公开了使用封装的NERS-活性结构来执行NERS的方法。

公开(公告)号：US08319963B2

公开(公告)日：2012-11-27

申请号：US12772063

申请日：2010-04-30

Applicant: Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Min Hu ,  Wei Wu ,  Fung Suong Ou ,  Zhen Peng ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658 ,  G01N21/7746

Abstract: A compact sensor system comprising: an analysis cell configured for photon-matter interaction, where photons are received from a light source; and an integrated-optical spectral analyzer configured for identifying a set of frequencies, the integrated-optical spectral analyzer comprising: a waveguide coupled with the analysis cell, the waveguide configured for propagating a set of frequencies through the waveguide; one or more ring resonators coupled with the waveguide, the one or more ring resonators comprising a predetermined bandwidth and configured for capturing the set of frequencies corresponding to frequencies within the predetermined bandwidth; and one or more frequency detectors coupled with the one or more tunable ring resonators, the one or more frequency detectors configured for generating electrical signals that identify each of the set of frequencies.

Abstract translation: 一种紧凑的传感器系统，包括：配置用于光子 - 物质相互作用的分析单元，其中从光源接收光子; 所述集成光谱分析仪包括：与所述分析单元耦合的波导，所述波导被配置为通过所述波导传播一组频率;以及波导，其被配置为用于识别一组频率。 一个或多个与所述波导耦合的环形谐振器，所述一个或多个环形谐振器包括预定带宽并被配置用于捕获与所述预定带宽内的频率相对应的频率集合; 以及与所述一个或多个可调环形谐振器耦合的一个或多个频率检测器，所述一个或多个频率检测器被配置用于产生标识所述一组频率中的每一个的电信号。

公开(公告)号：US20110267608A1

公开(公告)日：2011-11-03

申请号：US12771779

申请日：2010-04-30

Applicant: Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable layer and a plurality of SERS-active nanoparticles disposed at one or more locations on the deformable layer, wherein the one or more locations are configured to be illuminated with light of a pump wavelength to cause Raman excitation light to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles. In addition, a morphology of the deformable layer is configured to be controllably varied to modify an intensity of the Raman scattered light produced from the molecules.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的可调谐装置包括可变形层和设置在可变形层上的一个或多个位置处的多个SERS活性纳米颗粒，其中所述一个或多个位置被配置为用 泵浦波长以使拉曼激发光与纳米颗粒相互作用，并从靠近纳米颗粒的分子产生增强的拉曼散射光。 此外，可变形层的形态被配置为可控地改变以改变由分子产生的拉曼散射光的强度。

公开(公告)号：US07385691B2

公开(公告)日：2008-06-10

申请号：US11044676

申请日：2005-01-27

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44 ,  H01L31/02325 ,  H01L31/105

Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed on the substrate or apart from the substrate. The molecular analysis device also include a radiation receiver disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

Abstract translation: 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在基板上或者离开基板。 分子分析装置还包括设置在基板上并被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射的辐射接收器。

公开(公告)号：US08993339B2

公开(公告)日：2015-03-31

申请号：US14006721

申请日：2011-03-23

Applicant: Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

Inventor： Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

IPC: G01N21/00 ,  G01N21/65 ,  G01N21/552 ,  G01N21/64

CPC classification number: G01N21/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658

Abstract: A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed.

Abstract translation: 公开了用于分子分析的杂化纳米结构。 该结构包括多个纳米针，其中每个纳米针涂覆有金属涂层，其一端连接到基底，并且可沿其长度自由弯曲，使得每个纳米针的第二端能够朝向彼此移动以形成 一个空腔。 该结构还包括捕获在空腔中的纳米颗粒。 还公开了一系列混合纳米结构和制备混合纳米结构的方法。

公开(公告)号：US20130195721A1

公开(公告)日：2013-08-01

申请号：US13879245

申请日：2010-10-20

Applicant: Zhiyong Li ,  R. Stanley Williams

Inventor： Zhiyong Li ,  R. Stanley Williams

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N21/648

Abstract: A metallic-nanofinger device for chemical sensing. The device includes a substrate, and a plurality of nanofingers. A nanofinger includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least the metallic cap and a second metallic cap of respective nanofinger and second nanofinger. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A coating encapsulating the metallic cap to respond upon exposure to a liquid, and a chemical-sensing chip including the metallic-nanofinger device are also provided.

Abstract translation: 用于化学感应的金属纳米膜装置。 该装置包括基板和多个纳米装置。 纳米针框包括柔性柱和与柔性柱的顶点相连的金属帽。 至少纳米酮和第二纳米酮将自排列成紧密堆积的构型，其中至少一个分析物分子设置在至少金属盖和相应的纳芬酮和第二纳米酮之间的第二金属盖之间。 金属帽的形态是产生与来自分析物分子的放大发光相关的移位等离子体共振峰。 还提供了包封金属盖以在暴露于液体时响应的涂层，以及包括金属纳米酮装置的化学感测芯片。

公开(公告)号：US20130040862A1

公开(公告)日：2013-02-14

申请号：US13636799

申请日：2010-04-20

Applicant: Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

Inventor： Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Wei Wu ,  R. Stanley Williams

IPC: C40B40/14 ,  C40B50/14 ,  C40B40/18 ,  C40B40/04 ,  B82Y15/00

CPC classification number: G01N21/658

Abstract: A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.

Abstract translation: 提供了一种用于分子分析的多支柱结构。 该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。 至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。 每个纳米孔涂有金属涂层。 还提供了这种多支柱结构的阵列。 还提供了一种制备多支柱结构的方法。

公开(公告)号：US08111143B2

公开(公告)日：2012-02-07

申请号：US11117976

申请日：2005-04-29

Applicant: William Tong ,  Geoffrey Lyon ,  Philip Kuekes ,  Zhiyong Li ,  Shih-Yuan Wang ,  R. Stanley Williams

Inventor： William Tong ,  Geoffrey Lyon ,  Philip Kuekes ,  Zhiyong Li ,  Shih-Yuan Wang ,  R. Stanley Williams

IPC: H04Q5/22

CPC classification number: G01D21/00 ,  H04Q9/00

Abstract: An assembly for monitoring an environment includes a RFID tag and a sensing unit. The sensing unit is configured to be activated by a RF signal received by the RFID tag and to sense information regarding an environment.

Abstract translation: 用于监测环境的组件包括RFID标签和感测单元。 感测单元被配置为由RFID标签接收的RF信号激活并且感测关于环境的信息。

公开(公告)号：US07924413B2

公开(公告)日：2011-04-12

申请号：US12074133

申请日：2008-02-29

Applicant: R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Theodore I. Kamins ,  Duncan Stewart ,  Alexandre M. Bratkovski ,  Jason Blackstock ,  Zhiyong Li

Inventor： R. Stanley Williams ,  Shih-Yuan Wang ,  Philip J. Kuekes ,  Theodore I. Kamins ,  Duncan Stewart ,  Alexandre M. Bratkovski ,  Jason Blackstock ,  Zhiyong Li

IPC: G01N21/00

CPC classification number: H01L33/18 ,  B82Y20/00 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/068 ,  H01L33/06 ,  H01L33/08 ,  H01S5/341 ,  H01S5/4031

Abstract: Embodiments of the present invention are related to nanowire-based devices that can be configured and operated as modulators, chemical sensors, and light-detection devices. In one aspect, a nanowire-based device includes a reflective member, a resonant cavity surrounded by at least a portion of the reflective member, and at least one nanowire disposed within the resonant cavity. The nanowire includes at least one active segment selectively disposed along the length of the nanowire to substantially coincide with at least one antinode of light resonating within the cavity. The active segment can be configured to interact with the light resonating within the cavity.

Abstract translation: 本发明的实施例涉及可以配置和操作为调制器，化学传感器和光检测装置的基于纳米线的器件。 在一个方面，基于纳米线的器件包括反射部件，由反射部件的至少一部分包围的谐振腔以及设置在谐振腔内的至少一个纳米线。 纳米线包括至少一个有源区段，沿着纳米线的长度选择性地设置，以与腔内谐振的至少一个光波导基本重合。 活动段可以被配置为与腔内共振的光相互作用。