公开(公告)号：US08577445B2

公开(公告)日：2013-11-05

申请号：US10539519

申请日：2003-12-12

Applicant: Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

Inventor： Frederic Berier ,  Bertrand Viellerobe ,  Magalie Genet ,  Francois Lacombe ,  Pedro Santos

IPC: A61B5/05

CPC classification number: G02B21/0072 ,  A61B1/0008 ,  A61B1/00172 ,  G02B21/0028 ,  G02B23/2407 ,  G02B26/0875 ,  G02B26/101

Abstract: An optical head includes: a point source producing an excitation beam, optical elements adapted to converge the optical beam into an excitation point located in a subsurface plane relative to the surface of a sample, the plane being perpendicular to the optical axis of the optical head; and elements for scanning the excitation point so as to define an observation field in the subsurface plane along two perpendicular scanning directions, a rapid online scanning and a slow columnar scanning. The invention includes micro-electrical mechanical systems designed to move in translation along a selected displacement at least one of the optical elements, which is mobile along a direction perpendicular to the optical axis so as to obtain at least one of the scanning directions. The invention provides the advantages of maintaining an axial illumination of the sample and of using a miniature head.

Abstract translation: 光头包括：产生激发光束的点光源，适于将光束会聚到位于相对于样品表面的地下平面内的激发点的光学元件，该平面垂直于光学头的光轴 ; 以及用于扫描激发点的元件，以便沿着两个垂直扫描方向在地下平面中定义观察场，快速在线扫描和慢速柱状扫描。 本发明包括微电机械系统，其被设计成沿着沿着与光轴垂直的方向移动的至少一个光学元件的选定位移平移地移动，以便获得扫描方向中的至少一个。 本发明提供了保持样品的轴向照明和使用微型头的优点。

公开(公告)号：US20120035484A1

公开(公告)日：2012-02-09

申请号：US12377819

申请日：2007-08-16

Applicant: Luc Thiberville ,  Charlotte Cave ,  Véronique Dentan ,  Nicolas Boularot ,  Geneviéve Bourg-Heckly ,  Eric Peltier

Inventor： Luc Thiberville ,  Charlotte Cave ,  Véronique Dentan ,  Nicolas Boularot ,  Geneviéve Bourg-Heckly ,  Eric Peltier

IPC: A61B6/00 ,  A61B1/267

CPC classification number: A61B1/2676 ,  A61B1/00165 ,  A61B1/018 ,  A61B1/043 ,  A61B1/2736 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

Abstract: A method for imaging a tissue includes collecting a light signal from at least part of said tissue, using a fiber optic probe for fluorescence imaging, wherein the fiber optic probe comprises a plurality of optic fibers, and wherein a distal tip of the fiber optic probe is placed at a distance from said tissue, said imaging being made confocal at a proximal tip of said fiber optic probe. A fluorescence imaging system includes an endoscope equipped with a working channel, in which a fiber optic probe has been inserted, wherein the fiber optic probe is movable between a retracted position and at least one position of extension, said fiber optic probe comprising a plurality of optic fibers for performing imaging of a tissue, said imaging being confocal via a processor located at a proximal tip of said fiber optic probe.

Abstract translation: 用于成像组织的方法包括使用用于荧光成像的光纤探针收集来自所述组织的至少一部分的光信号，其中所述光纤探针包括多个光纤，并且其中所述光纤探针的远端 被放置在离所述组织一定距离处，所述成像在所述光纤探针的近端被共焦。 荧光成像系统包括配备有工作通道的内窥镜，其中插入了光纤探针，其中光纤探头可在缩回位置和至少一个延伸位置之间移动，所述光纤探头包括多个 用于执行组织成像的光纤，所述成像通过位于所述光纤探针的近端处的处理器共焦。

公开(公告)号：US20110274325A1

公开(公告)日：2011-11-10

申请号：US13144518

申请日：2010-01-29

Applicant: Tom Vercauteren ,  Aymeric Perchant ,  Francois Lacombe ,  Nicolas Savoire

Inventor： Tom Vercauteren ,  Aymeric Perchant ,  Francois Lacombe ,  Nicolas Savoire

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06T3/4038 ,  G06T3/4053 ,  G06T2207/10068 ,  G06T2207/30028 ,  G06T2207/30104

Abstract: A method for processing images acquired in real time through a medical device, said images being loaded into a buffer, comprising the steps of: stopping the loading of the images into the buffer, processing loaded images using an incremental algorithm, displaying successively intermediate results of the processing, resuming the loading and stopping the processing based on an evaluation of said intermediate results.

Abstract translation: 一种用于处理通过医疗设备实时获取的图像的方法，所述图像被加载到缓冲器中，包括以下步骤：停止将图像加载到缓冲器中，使用增量算法处理加载的图像，显​​示连续的中间结果 处理，基于所述中间结果的评估恢复加载和停止处理。

公开(公告)号：US20110254980A1

公开(公告)日：2011-10-20

申请号：US13141991

申请日：2009-12-28

Applicant: Aymeric Perchant ,  Nicolas Savoire

Inventor： Aymeric Perchant ,  Nicolas Savoire

IPC: H04N7/18 ,  H04N5/76

CPC classification number: G02B6/06 ,  G06T7/80 ,  G06T2207/10068

Abstract: A method to process an image acquired through an optical-fiber guide includes acquiring a first reference image through the optical-fiber guide, acquiring a second calibration image through the optical-fiber guide, spatially identifying each fiber of the optical-fiber guide of the second calibration image in a first detection map, acquiring a recalibration image through the optical-fiber guide, determining a geometrical transformation to make the recalibration image coincide with the first reference image, deriving a new detection map spatially identifying each fiber of the optical-fiber guide of the recalibration image, wherein the new detection map is derived using the geometrical transformation and the first detection map, and individually processing zones of an acquired image corresponding to each fiber of the optical-fiber guide using the new detection map.

Abstract translation: 一种处理通过光纤引导获得的图像的方法，包括：通过光纤引导获取第一参考图像，通过光纤引导获取第二校准图像，在空间上识别光纤引导件的每个光纤 在第一检测图中获取第二校准图像，通过光纤引导件获取重新校准图像，确定几何变换以使重新校准图像与第一参考图像一致，导出空间上识别光纤的每个光纤的新的检测图 引导重新校正图像，其中使用几何变换和第一检测图导出新的检测图，并且使用新的检测图单独处理与光纤引导件的每个光纤相对应的获取的图像的区域。

公开(公告)号：US07978932B2

公开(公告)日：2011-07-12

申请号：US11832674

申请日：2007-08-02

Applicant: Tom Vercauteren ,  Aymeric Perchant ,  Nicholas Ayache ,  Xavier Pennec ,  Gregoire Malandain

Inventor： Tom Vercauteren ,  Aymeric Perchant ,  Nicholas Ayache ,  Xavier Pennec ,  Gregoire Malandain

IPC: G06K9/36 ,  G06K9/32 ,  H04N7/00

CPC classification number: G06K9/00134 ,  G02B21/367 ,  G06T3/4038 ,  G06T7/35 ,  G06T2207/10056

Abstract: A mosaicing method taking into account motion distortions, irregularly sampled frames and non-rigid deformations of the imaged tissue. The method for mosaicing frames from a video sequence acquired from a scanning device such as a scanning microscope, includes the steps of: a) compensating for motion and motion distortion due to the scanning microscope, b) applying a global optimization of inter-frame registration to align consistently the frames c) applying a construction algorithm on the registered frames to construct a mosaic, and d) applying a fine frame-to-mosaic non rigid registration. The method is based on a hierarchical framework that is able to recover a globally consistent alignment of the input frames, to compensate for the motion distortions and to capture the non-rigid deformations.

Abstract translation: 考虑到运动失真，不规则采样帧和成像组织的非刚性变形的镶嵌方法。 从诸如扫描显微镜的扫描装置获取的视频序列拼接帧的方法包括以下步骤：a）补偿由扫描显微镜引起的运动和运动失真，b）应用帧间对准的全局优化 以一致地对准帧c）在注册的帧上应用构造算法以构建马赛克，以及d）应用精细的帧到马赛克非刚性注册。 该方法基于能够恢复输入帧的全局一致对齐的分层框架，以补偿运动失真并捕获非刚性变形。

公开(公告)号：US07336990B2

公开(公告)日：2008-02-26

申请号：US10500162

申请日：2002-12-20

Applicant: Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

Inventor： Magalie Genet ,  Geneviève Bourg-Heckly ,  Sandrine Vilette ,  François Lacombe ,  Alexandre Loiseau ,  Benjamin Abrat

IPC: A61B6/00

CPC classification number: G01N21/6486 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G01N21/6456

Abstract: An equipment includes an excitation source (1), elements for injecting (2) an excitation signal produced by the source in an ordered bundle (3) of flexible optical fibers, elements for analyzing (21, 22) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle (3) an optical head (4) designed to be placed in contact with the biological tissue (6), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle (3) to converge into a subsurface analyzing zone (5), the same optical fiber(s) used for excitation of the bundle (3) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements (2) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

Abstract translation: 一种设备包括激励源（1），用于注入（2）由柔性光纤的有序束（3）中的源产生的激励信号的元件，用于分析（21,22）发射的自发荧光信号的元件。 所述设备还包括在所述光纤束（3）的输出端处设计成与所述生物组织（6）接触的光学头（4），所述光学头装备有适于使所述激发信号输出 从束（3）收敛到地下分析区（5）中，用于激发束（3）的相同光纤用于检测由地下分析区发出的信号，元件（D） 放置在注入元件（2）的上游的进一步提供以分离激发信号的波长和自发荧光信号的波长。

公开(公告)号：US07285089B2

公开(公告)日：2007-10-23

申请号：US10500160

申请日：2002-12-20

Applicant: Bertrand Viellerobe ,  Magalie Genet ,  Frédéric Berier ,  François Lacombe ,  Aymeric Perchant ,  Georges Le Goualher ,  Sandra Marti ,  Stéphane Bourriaux

Inventor： Bertrand Viellerobe ,  Magalie Genet ,  Frédéric Berier ,  François Lacombe ,  Aymeric Perchant ,  Georges Le Goualher ,  Sandra Marti ,  Stéphane Bourriaux

IPC: A61B1/06 ,  G02B26/08

CPC classification number: A61B1/00188 ,  A61B1/00165 ,  A61B1/042 ,  A61B1/07 ,  A61B2562/0242 ,  G02B23/2469

Abstract: Equipment includes an image guide (1) consisting of flexible optical fibers with: on the proximal end side: a source (2), angular scanning elements (3), injection elements (4) in one of the fibers, elements for splitting (5) the illuminating beam and the backscattered signal, elements for spatial filtering (6), elements for detecting (7) the signal, electronic elements (8) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head (9) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M1) and a galvanometric field mirror (M2) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M1, M2) firstly in the field mirror (M2) and the injection elements (4) in the image guide in a second step.

Abstract translation: 设备包括由柔性光纤组成的图像引导件（1），其具有：在基端侧：源（2），角扫描元件（3），其中一个光纤中的注入元件（4），用于分离的元件（5 ）照明光束和反向散射信号，用于空间滤波的元件（6），用于检测信号的元件（7），用于控制，分析和数字处理检测信号和显示的电子元件（8）; 并且在远端侧：用于聚焦从照明光纤出射的照明光束的光学头（9）。 扫描元件包括谐振线路反射镜（M1）和具有可变频率的电流计镜（M 2）和适于首先在场反射镜（M 2）和图像引导件中的注入元件（4）。

公开(公告)号：US07221824B2

公开(公告)日：2007-05-22

申请号：US10499987

申请日：2002-12-20

Applicant: Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

Inventor： Frederic Berier ,  Stephane Bourriaux ,  Magalie Genet ,  Bertrand Viellerobe ,  Alexandre Loiseau ,  Benjamin Abrat

IPC: G02B6/32 ,  G02B6/06 ,  G02B27/02

CPC classification number: A61B1/00188 ,  A61B2562/0242 ,  A61B2562/146

Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

Abstract translation: 一种用于装备柔性光纤束的远端的光学头，设计成被推动与分析表面接触并且包括用于将激发信号聚焦到位于分析器下方特定深度处的所谓的激发焦点的光学元件 表面，并对由纤维束承载的激发焦点反向散射的信号采样。 头部包括光纤保持器管，其中插入在纤维束的远端部分的一侧和另一个光学元件上，其中光学元件包括与纤维束的端部接触的板，其中指数接近 光纤芯和聚焦光学块的输出窗口进一步提供适于提供指标适应以消除在分析表面上发生的寄生反射。

公开(公告)号：USD1057759S1

公开(公告)日：2025-01-14

申请号：US29904371

申请日：2023-10-05

Applicant: Mauna Kea Technologies

Designer： Francois Lacombe ,  Margery Rothenberg

公开(公告)号：US09730586B2

公开(公告)日：2017-08-15

申请号：US14731949

申请日：2015-06-05

Applicant: Mauna Kea Technologies

Inventor： Nicolas Boularot ,  Arnaud Cressant

IPC: A61B5/00 ,  A61B1/00 ,  G02B23/26 ,  A61B90/11 ,  A61B1/313

CPC classification number: A61B5/0084 ,  A61B1/00154 ,  A61B1/313 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/6814 ,  A61B5/6864 ,  A61B5/6868 ,  A61B5/6882 ,  A61B90/11 ,  A61B2503/40 ,  A61B2560/063 ,  A61B2562/0238 ,  G02B23/26

Abstract: An intracranial implant to position a fiber bundle to a specified region of a brain of an animal. The implant may include a base support to be fixed to a skull of the animal over an orifice drilled in the skull, a hollow conduit arranged through the base support to guide the fiber bundle to the brain of the animal through the drilled orifice and a first locking member arranged on the base support, to cooperate with a ferrule of the fiber bundle, the first locking member configured to lock the fiber bundle to the specified region of the brain of the animal.