公开(公告)号：US10466326B2

公开(公告)日：2019-11-05

申请号：US15574431

申请日：2016-05-13

Applicant: STC.UNM

Inventor： Laurel Sillerud

IPC: G01R33/56 ,  G01R33/465 ,  B82Y15/00 ,  G06T7/00

Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.

公开(公告)号：US20180110774A1

公开(公告)日：2018-04-26

申请号：US15570042

申请日：2016-04-28

Applicant: STC.UNM

Inventor： Laura V. Gonzalez Bosc ,  Levi D. Maston ,  Thomas Resta

IPC: A61K31/495 ,  A61P9/12 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0078 ,  A61K31/192 ,  A61K31/343 ,  A61K31/426 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5578 ,  A61K45/06 ,  A61P9/12 ,  C07D277/38 ,  C07D295/108 ,  A61K2300/00

Abstract: Methods and composition for treating or preventing pulmonary hypertension are provided. In certain aspects, compounds that inhibit TH17 cell maturation or activity, such as retinoic acid receptor-related orphan nuclear receptor (ROR) inhibitors, are used to for the treatment of pulmonary hypertension.

公开(公告)号：US20160241042A1

公开(公告)日：2016-08-18

申请号：US15031125

申请日：2014-10-21

Applicant: Andrea A. MAMMOLI ,  Olga LAVROVA ,  Brian ARELLANO ,  Feng CHENG ,  Wesley GREENWOOD ,  Jonathan HAWKINS ,  Steve WILLARD ,  STC.UNM

Inventor： Andrea A. Mammoli ,  Olga Lavrova ,  Brian Arellano ,  Feng Cheng ,  Wesley Greenwood ,  Jonathan Hawkins ,  Steve Willard

IPC: H02J3/38 ,  H02M3/04 ,  H02J7/00 ,  H02M7/44

CPC classification number: H02J3/383 ,  H02J3/12 ,  H02J3/32 ,  H02J3/386 ,  H02J7/0068 ,  H02M3/04 ,  H02M7/44 ,  H02S40/38 ,  Y02E10/563 ,  Y02E10/566 ,  Y02E70/30

Abstract: The present invention is an apparatus and method for delivering energy using a renewable resource. The method includes providing a photovoltaic energy source and applying energy storage to the photovoltaic energy source via a battery storage unit. The energy output from the photovoltaic energy source and the battery system is controlled using a battery control system. The battery control system predicts peak load, develops a schedule that includes when to begin discharging power and when to stop discharging power, shifts power to the battery storage unit when excess power is available, and prioritizes the functionality of the battery storage unit and the photovoltaic energy source.

Abstract translation: 本发明是一种使用可再生资源传递能量的装置和方法。 该方法包括提供光伏能源并且经由电池存储单元向光伏能源施加能量存储。 使用电池控制系统控制来自光伏能源和电池系统的能量输出。 电池控制系统预测峰值负载，制定包括何时开始放电并且何时停止放电的时间表，在多余电力可用时将电力转移到电池存储单元，并且优先考虑电池存储单元和光伏的功能 能量源。

公开(公告)号：US09125415B2

公开(公告)日：2015-09-08

申请号：US14127465

申请日：2012-07-05

Applicant: Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Whitten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

Inventor： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Whitten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

IPC: A01N43/82 ,  A01N43/10 ,  C07D409/14 ,  C07D417/14 ,  A01N43/647 ,  A61L2/08 ,  A61L2/16

CPC classification number: A01N43/82 ,  A01N43/10 ,  A01N43/647 ,  A61L2/084 ,  A61L2/16 ,  C07D409/14 ,  C07D417/14

Abstract: Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

Abstract translation: 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。

公开(公告)号：US20150050292A1

公开(公告)日：2015-02-19

申请号：US13967259

申请日：2013-08-14

Applicant: Thomas R. Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Rick Lyons

Inventor： Thomas R. Kozel ,  William Murphy ,  Suzanne Brandt ,  Bruce R. Blazar ,  Julie A. Lovchik ,  Peter Thorkildson ,  Ann Percival ,  C. Rick Lyons

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  A61K39/07 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6081 ,  C07K16/1278 ,  C07K16/2878 ,  C07K2317/75 ,  C07K2317/92 ,  G01N2333/32 ,  A61K2300/00

Abstract: Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused by Bacillus anthracis or other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

Abstract translation: 用于检测，预防或治疗炭疽或其他传染病的组合物和方法。 一方面，本发明提供了用于免疫人或动物针对炭疽芽孢杆菌或其他包裹的病原体的方法。 所述方法包括向人或动物施用目的病原体的荚膜多肽和CD40激动剂。 荚膜多肽或CD40激动剂以可以在人或动物中针对感兴趣的病原体引起免疫保护反应的量或频率施用。 另一方面，本发明提供了使用被动免疫与抗荚膜多肽抗体来预防或治疗由炭疽芽孢杆菌或其他病原体引起的感染的方法。 另一方面，本发明提供了通过检测血清或其他生物样品中的荚膜多肽来诊断炭疽的方法。

公开(公告)号：US20110092533A1

公开(公告)日：2011-04-21

申请号：US12967871

申请日：2010-12-14

Applicant: Eric R. PROSSNITZ ,  Sergey E. Tkatchenko ,  Chetana M. Revankar ,  Larry A. Sklar ,  Jeffrey B. Arterburn ,  Daniel F. Cimino ,  Tudor I. Oprea ,  Cristian-George Bologa ,  Bruce S. Edwards ,  Alexander Kiselyov ,  Susan M. Young

Inventor： Eric R. PROSSNITZ ,  Sergey E. Tkatchenko ,  Chetana M. Revankar ,  Larry A. Sklar ,  Jeffrey B. Arterburn ,  Daniel F. Cimino ,  Tudor I. Oprea ,  Cristian-George Bologa ,  Bruce S. Edwards ,  Alexander Kiselyov ,  Susan M. Young

IPC: A61K31/435 ,  C07D405/10 ,  C07D221/16 ,  C07D405/14 ,  A61P43/00

CPC classification number: C07D221/16 ,  C07D405/04 ,  C07D405/14

Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ERα and ERβ). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors. Diseases which are mediated through one or more of these receptors include cancer (particularly breast, reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometreitis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disoders such as Parkinson's disease and Alzheimer's disease, as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

Abstract translation: 本发明在分子生物学/药理学领域，并提供调节GPR30以及经典雌激素受体α和β（ERα和ER和bgr）的作用的化合物。 这些化合物可以用作一种或多种所公开的雌激素受体的激动剂和/或拮抗剂。 通过这些受体中的一种或多种介导的疾病包括癌症（特别是乳腺，生殖和其他激素依赖性癌症，白血病，结肠癌，前列腺癌），生殖（泌尿 - 泌尿）包括子宫内膜炎，前列腺炎，多囊卵巢综合征，膀胱 控制，激素相关疾病，听觉障碍，心血管疾病，包括潮热和大量出汗，高血压，中风，肥胖，骨质疏松症，血液病，血管疾病或诸如静脉血栓形成，动脉粥样硬化等疾病，以及许多其他疾病和中枢和 周围神经系统，包括抑郁症，失眠，焦虑，多发性硬化，神经病变，神经变性解码器如帕金森病和阿尔茨海默病，以及炎性肠病，克罗恩病，腹腔（腹腔）疾病和肠道相关疾病。 用于预防或减少性交后怀孕的可能性的避孕指示是本发明的另一方面。

公开(公告)号：US20090226521A1

公开(公告)日：2009-09-10

申请号：US12313847

申请日：2008-11-25

Applicant: Hugh D. Smyth ,  Marek Osinski ,  Shayna L. McGill

Inventor： Hugh D. Smyth ,  Marek Osinski ,  Shayna L. McGill

IPC: A61K9/10 ,  A61K9/14 ,  A61K31/711

CPC classification number: A61K9/0009 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/7023 ,  A61K41/0052 ,  A61K47/6921 ,  A61K47/6923

Abstract: Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

Abstract translation: 活性多功能纳米颗粒由于在磁场的影响下通过粘液和生物屏障增加扩散和渗透而提供模型治疗和基因试剂的功效的显着增强。

公开(公告)号：US10522843B1

公开(公告)日：2019-12-31

申请号：US15423763

申请日：2017-02-03

Applicant: Alexey Serov ,  Plamen B Atanassov ,  Tomokazu Sakamoto ,  Hirohisa Tanaka ,  Koichiro Asazawa

Inventor： Alexey Serov ,  Plamen B Atanassov ,  Tomokazu Sakamoto ,  Hirohisa Tanaka ,  Koichiro Asazawa

IPC: H01M4/90 ,  H01M8/22

Abstract: A supported bi-metallic non-platinum catalyst that is capable of oxidizing hydrazine to produce, as by-products of energy production, nitrogen, water, and zero or near-zero levels of ammonia is described. The catalyst is suitable for use in fuel cells, particularly those that utilizes an anion-exchange membrane and a liquid fuel such as hydrazine.

公开(公告)号：US09671297B2

公开(公告)日：2017-06-06

申请号：US14434313

申请日：2013-10-07

Applicant: STC.UNM ,  Scott Sibbett

Inventor： Scott Sibbett

IPC: G01L1/22 ,  B25J19/02 ,  G06F3/041 ,  G01L1/18 ,  G01L1/20 ,  G01L1/04 ,  G06F3/045 ,  B25J13/08 ,  G01L5/16

CPC classification number: G01L1/22 ,  B25J13/084 ,  B25J19/02 ,  G01L1/04 ,  G01L1/18 ,  G01L1/205 ,  G01L5/162 ,  G06F3/041 ,  G06F3/0414 ,  G06F3/045

Abstract: A pliable pressure sensitive sensor device and method of making the same is provided. The sensor includes first and second pliable protective layers, which cover sets of conductive fibers that spatially separated by an electrically conductive pliable layer, which deforms in response to a pressure event. The fiber sets form a grid pattern and are in electrical communication with sets of electrical contacts located in predetermined locations along the fibers. In response to a pressure event in proximity to the contact, the pliable layer deforms and increases the amount of surface area in contact with an electrical contact whereby an electrical resistance at an individual electrical contact decreases in response to the pressure event.

公开(公告)号：US09542198B2

公开(公告)日：2017-01-10

申请号：US14791627

申请日：2015-07-06

Applicant: STC.UNM

Inventor： Marios Stephanou Pattichis ,  Yuebing Jiang ,  Daniel Rolando Llamocca Obregon

IPC: G06F9/455 ,  G06F17/50 ,  G06F9/44 ,  H03H17/06 ,  H04N19/625 ,  H03H17/02

CPC classification number: G06F9/4401 ,  G06F17/5054 ,  G06F2217/08 ,  H03H17/0241 ,  H03H17/0294 ,  H03H17/06 ,  H04N19/625

Abstract: A dynamically reconfigurable framework manages processing applications in order to meet time-varying constraints to select an optimal hardware architecture. The optimal architecture satisfies time-varying constraints including for example, supplied power, required performance, accuracy levels, available bandwidth, and quality of output such as image reconstruction. The process of determining an optimal solution is defined in terms of multi-objective optimization using Pareto-optimal realizations.

Abstract translation: 动态可重构框架管理处理应用程序，以便满足时变约束以选择最佳硬件体系结构。 最优架构满足时变约束，包括例如所提供的功率，所需性能，精度水平，可用带宽以及诸如图像重建的输出质量。 确定最优解的过程是使用帕累托最优实现的多目标优化来定义的。