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    3-DIMENSIONAL REPRESENTATIONS OF POST-CONTRAST ENHANCED BRAIN LESIONS
    11.
    发明公开
    3-DIMENSIONAL REPRESENTATIONS OF POST-CONTRAST ENHANCED BRAIN LESIONS 审中-公开

    公开(公告)号：US20240168117A1

    公开(公告)日：2024-05-23

    申请号：US18425964

    申请日：2024-01-29

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    发明人： Darin OKUDA

    IPC分类号： G01R33/56 ,  G01R33/48 ,  G06N20/00 ,  G06T7/11

    CPC分类号： G01R33/5608 ,  G01R33/4822 ,  G01R33/5601 ,  G06N20/00 ,  G06T7/11 ,  G06T2207/10088 ,  G06T2207/30016 ,  G06T2207/30096

    摘要： 3D MRI images of the brain may be created and acquired. After administration of contrast, brain lesions and other abnormalities may be identified and isolated from the 3D MRI images, with each lesion serving as a region of interest (ROI). 3D region of contrast enhancement images may be created from segmented 3D MRI images and different regions of contrast enhancement of the brain lesion may be depicted. Saved regions of contrast enhancement may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D region of contrast enhancement images may be used to create 3D printed models of the isolated region of contrast enhancement. Analysis of the 3D brain region of contrast enhancement images and the 3D printed region of contrast enhancement models may enable a more efficient and accurate way of determining brain lesion risk factors and effective treatment regimens.

    METHODS FOR RECONSTITUTING T CELL SELECTION AND USES THEREOF
    12.
    发明公开
    METHODS FOR RECONSTITUTING T CELL SELECTION AND USES THEREOF 审中-公开

    公开(公告)号：US20240161874A1

    公开(公告)日：2024-05-16

    申请号：US18281085

    申请日：2022-03-11

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    发明人： Scott CHRISTLEY ,  Benjamin GREENBERG ,  Linsay COWELL ,  Jared OSTMEYER

    IPC分类号： G16B40/20 ,  G16H50/30

    CPC分类号： G16B40/20 ,  G16H50/30

    摘要： Provided herein is a machine learning model to reconstitute T cell and B cell selections, and methods of use thereof. The methods provided herein include methods of prediction of the risk of developing an autoimmune disease or disorder, the risk of developing alloimmunity from organ or cellular transplant, the risk of developing graft-versus-host disease (GvHD) from organ or cellular transplant, the risk of developing alloimmunity from an adoptive T cell therapy, the risk of developing alloimmunity from a chimeric antigen receptor (CAR)-T cell therapy, and methods of prediction of the safety of an antibody drug in a subject. Also provided herein is a method of classifying T cell receptor p (TCRp) gene, and methods of use thereof. The methods provided include methods of determining an organ donor/organ recipient compatibility, methods of predicting graft versus host disease (GvHD) in a recipient, acute GvHD (aGvHD), chronic GvHD (cGvHD) and cancer relapse in a subject.