公开(公告)号：US20120258150A1

公开(公告)日：2012-10-11

申请号：US13433341

申请日：2012-03-29

Applicant: Holly Balasubramanian Rauckhorst ,  Vicenzo D'Acchioli ,  Andreas Josef Dreher

Inventor： Holly Balasubramanian Rauckhorst ,  Vicenzo D'Acchioli ,  Andreas Josef Dreher

IPC: A61K8/11 ,  B29B9/16 ,  A61K8/02 ,  C11D17/00 ,  C11D3/60 ,  A61L9/012 ,  A61K9/14 ,  A61K8/86 ,  A61K47/30 ,  A61K47/32 ,  A61K8/81 ,  A61P17/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/10 ,  B32B27/00 ,  B29B9/12

CPC classification number: C11D3/505 ,  A61K8/0258 ,  A61K8/0283 ,  A61K8/11 ,  A61K8/8135 ,  A61K2800/56 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q19/00 ,  A61Q19/10 ,  B01J13/043 ,  C11D17/0039 ,  Y10T428/2985 ,  Y10T428/2998

Abstract: Particles containing a polymer and a volatile material, such as a perfume, and particle gas saturated solution (PGSS) processes for making such particles are provided.

Abstract translation: 提供了含有聚合物和挥发性物质如香料和颗粒气体饱和溶液（PGSS）的制备这种颗粒的方法。

公开(公告)号：US20110171349A1

公开(公告)日：2011-07-14

申请号：US13056969

申请日：2009-07-31

Applicant: Albert Thijs Poortinga ,  Daniela Oana Trambitas ,  Gerard Willem Hofland

Inventor： Albert Thijs Poortinga ,  Daniela Oana Trambitas ,  Gerard Willem Hofland

IPC: A23P1/04

CPC classification number: A61K9/5089 ,  A61K9/501 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K9/5052 ,  B01J13/043

Abstract: The present invention relates to a microencapsulate comprising microcapsules having a diameter of 0.1 μm to 25 μm, said microcapsules comprising: —a core particle having a diameter of 90 nm to 23 μm and containing at least 3% of the active component by weight of said core particle; and—a coating that fully envelops the core particle and containing at least 20 wt. % of a hydrophobic polymer selected from cellulosic ethers, cellulosic esters, zein, shellac, gluten, polylactide, hydrophobic starch derivatives, polyvinyl acetate polymers, polymers or copolymers derived from an acrylic acid ester and/or a methacrylic acid ester and combinations thereof; wherein the core particle contains a release trigger component and/or the coating contains a release trigger component, said release trigger component being selected from: —a water-swellable polymer having a water-uptake capacity at 37° C. and pH 7.0 of less than 20 wt. % and a water-uptake capacity at 37° C. and pH 2.0 of at least 50 wt. %; an—an edible salt having a water solubility at 37° C. and a pH of 7.0 of less than 1 mg/ml and a water solubility at 37° C. and a pH of 2.0 of at least 5 mg/ml; The microencapsulate of the present invention does not release the encapsulated active component when incorporated in water-containing foodstuffs, beverages, nutritional compositions or pharmaceutical compositions. Following ingestion, however, the active component is released rapidly.

Abstract translation: 本发明涉及一种包含直径为0.1μm至25μm的微胶囊的微胶囊，所述微胶囊包括： - 直径为90nm至23μm的核心颗粒，并含有至少3重量％的活性组分 核心颗粒; 和 - 完全包封核心颗粒并含有至少20wt。 选自纤维素醚，纤维素酯，玉米蛋白，虫胶，麸质，聚丙交酯，疏水性淀粉衍生物，聚乙酸乙烯酯聚合物，衍生自丙烯酸酯和/或甲基丙烯酸酯的聚合物或共聚物的疏水性聚合物的％和其组合; 其中所述核心颗粒含有释放触发组分和/或所述涂层含有释放触发组分，所述释放触发组分选自： - 水溶胀性聚合物，其具有37℃的吸水能力和较低的吸水能力 超过20wt。 ％和在37℃和pH 2.0下的吸水能力至少为50wt。 ％; 一种在37℃下具有水溶性，pH7.0小于1mg / ml，水溶解度在37℃，pH为2.0的至少5mg / ml的食用盐; 当掺入含水食品，饮料，营养组合物或药物组合物中时，本发明的微胶囊剂不释放包封的活性成分。 然而，摄入后，活性成分迅速释放。

公开(公告)号：US20110123680A1

公开(公告)日：2011-05-26

申请号：US12999214

申请日：2009-07-22

Applicant: Masato Tanaka ,  Norihiko Tsuchimoto

Inventor： Masato Tanaka ,  Norihiko Tsuchimoto

IPC: A23L1/00

CPC classification number: B01J13/046 ,  A23L29/256 ,  A23L33/105 ,  A23P10/30 ,  A23P30/10 ,  A61K9/5036 ,  A61K9/5089 ,  B01J13/043

Abstract: The method of producing microcapsules 100 comprises a primary dispersion step in which a water-soluble substance and a fat-soluble substance are mixed to obtain a primary dispersion liquid having primary dispersion particles 10 composed of the water-soluble substance dispersed in the fat-soluble substance, a secondary dispersion step in which the primary dispersion liquid and a sodium alginate aqueous solution are mixed to obtain a secondary dispersion liquid having secondary dispersion particles 20 composed of the primary dispersion liquid dispersed in the sodium alginate aqueous solution, and a spraying step in which the secondary dispersion liquid is sprayed for contact with a calcium ion-containing solution 9 to form a calcium alginate gel 30 and to obtain microcapsules 100 having the secondary dispersion particles 20 dispersed in the calcium alginate gel 30.

Abstract translation: 微胶囊100的制造方法包括一次分散步骤，其中将水溶性物质和脂溶性物质混合，得到一次分散液，其具有由分散在脂溶性中的水溶性物质构成的一次分散粒子10 物质，二次分散步骤，其中将一次分散液和藻酸钠水溶液混合，得到具有由分散在藻酸钠水溶液中的一次分散液构成的二次分散粒子20的二次分散液，以及喷雾步骤 将二次分散液喷雾与含钙离子的溶液9接触以形成藻酸钙凝胶30，得到分散在藻酸钙凝胶30中的第二分散粒子20的微胶囊100。

公开(公告)号：US20080145477A1

公开(公告)日：2008-06-19

申请号：US12022012

申请日：2008-01-29

Applicant: Chungsea A. Shen ,  Armando J. Castro ,  Michael Catizone ,  Bruno Padovani ,  David G. Barkalow ,  Xiaohu Xia ,  Michael S. Haas ,  Eric J. Dowd

Inventor： Chungsea A. Shen ,  Armando J. Castro ,  Michael Catizone ,  Bruno Padovani ,  David G. Barkalow ,  Xiaohu Xia ,  Michael S. Haas ,  Eric J. Dowd

IPC: A23G4/06

CPC classification number: B01J13/043 ,  A23G4/066 ,  A23G4/20 ,  A23J7/00 ,  A23L29/10 ,  A23P20/10 ,  A23P20/105 ,  A23V2002/00 ,  B01J13/04 ,  A23V2200/22 ,  A23V2250/1842

Abstract: A chewing gum comprises a primary chewing gum composition comprising gum base, a sweetener and a flavoring agent and a food acceptable delayed-release modification agent. The delayed-release modification agent reacts with the primary chewing gum composition after a chewed cud of the gum composition is formed, causing the primary gum to exhibit increased environmental acceptability after the chewed cud is discarded.

Abstract translation: 口香糖包括含有胶基，甜味剂和调味剂的主要口香糖组合物和食品可接受的延迟释放改性剂。 在形成牙龈组合物的咀嚼嚼后，延迟释放改性剂与初级口香糖组合物反应，导致在咀嚼嚼剔除之后，初级牙龈表现出增加的环境可接受性。

公开(公告)号：US06709650B1

公开(公告)日：2004-03-23

申请号：US09382561

申请日：1999-08-25

Applicant: Andrew D. Sutton ,  Richard A. Johnson ,  Peter J. Senior ,  David Heath

Inventor： Andrew D. Sutton ,  Richard A. Johnson ,  Peter J. Senior ,  David Heath

IPC: A61K3843

CPC classification number: A61K9/0075 ,  A61K9/1688 ,  A61K9/1694 ,  A61K9/5089 ,  A61K49/00 ,  A61K49/223 ,  A61K49/225 ,  B01J13/04 ,  B01J13/043 ,  B01J13/14 ,  Y10S514/965

Abstract: Microparticles of a water-soluble material, which are smooth and spherical, and at least 90% of which have a mass median particle size of 1 to 10 &mgr;m, and which carry a therapeutic or diagnostic agent can successfully be used in dry powder inhalers to deliver the said agent.

公开(公告)号：US20030207752A1

公开(公告)日：2003-11-06

申请号：US10392680

申请日：2003-03-20

Inventor： Hien N. Pham ,  Abhaya K. Datye

IPC: B01J029/06

CPC classification number: B01J13/043 ,  B01J21/08 ,  B01J23/745 ,  B01J35/10 ,  B01J35/1061 ,  B01J35/109 ,  B01J37/0018 ,  B01J37/0045

Abstract: A method and composition of matter relating to mesoporous structures. The inventive method and inventive structures relate to, for example, attrition-resistant heterogeneous catalysts. A preferred embodiment makes use of a liquid-crystal template mechanism to create a silica structure where insoluble nanoparticles (generally submicron particles) are trapped inside. Such a structure provides controlled porosity for transport of reactants to and products from the catalytically active phase, respectively. Catalytically active structures of the present invention are useful for Fischer-Tropsch synthesis where the breakup and attrition of the catalytically active phase ordinarily hinders performance. The method of the present invention is generally applicable to other mesoporous materials and active phase combinations.

Abstract translation: 与介孔结构相关的物质的方法和组成。 本发明的方法和本发明的结构涉及例如抗磨耗的非均相催化剂。 优选的实施方案使用液晶模板机制来产生二氧化硅结构，其中不溶性纳米颗粒（通常为亚微米颗粒）被捕获在内部。 这种结构分别提供用于将反应物输送到催化活性相和从催化活性相的产物的受控孔隙率。 本发明的催化活性结构可用于费 - 托合成，其中催化活性相的分解和磨损通常阻碍性能。 本发明的方法通常适用于其它介孔材料和活性相组合。

公开(公告)号：US06482433B1

公开(公告)日：2002-11-19

申请号：US09606518

申请日：2000-06-29

Applicant: Kris Bart DeRoos ,  Matthias Perren ,  Gregory Alan Sherman

Inventor： Kris Bart DeRoos ,  Matthias Perren ,  Gregory Alan Sherman

IPC: A61K914

CPC classification number: B01J13/043 ,  A23L27/70 ,  A23L27/80 ,  A23P10/30 ,  A23P10/40 ,  Y10S514/951

Abstract: A process for preparing free-flowing and, during handling, dust-free microparticles. The particles are at least 90% by weight, have a diameter of 100-400 &mgr;m, and contain one or more active ingredients in a glassy matrix. Generally, the process of the invention comprises the steps of (1) preparing an aqueous solution of the matrix materials, (2) mixing the flavor into the aqueous solution with stirring to form an emulsion or suspension, (3) spraying the emulsion in a spray drying tower under a supply of hot air to quickly create a semi-solid skin allowing outtake of moisture (water), and (4) subsequently subjecting the resulting particles to continued drying at lower temperatures in a fluid bed.

Abstract translation: 一种制备自由流动和处理过程中无尘的微粒的方法。 颗粒至少为90重量％，直径为100-400μm，并且在玻璃质基质中含有一种或多种活性成分。 通常，本发明的方法包括以下步骤：（1）制备基质材料的水溶液，（2）在搅拌下将风味剂混合到水溶液中以形成乳液或悬浮液，（3）将乳液喷雾在 喷雾干燥塔在热空气供应下快速产生半固体皮肤，允许除去水分（水），和（4）随后使所得颗粒在流化床中在较低温度下继续干燥。

公开(公告)号：US06312942B1

公开(公告)日：2001-11-06

申请号：US09197826

申请日：1998-11-23

Applicant: Raphael Plüss-Wenzinger ,  Fritz Widmer ,  Christoph Heinzen ,  Harry Brandenberger

Inventor： Raphael Plüss-Wenzinger ,  Fritz Widmer ,  Christoph Heinzen ,  Harry Brandenberger

IPC: C12M100

CPC classification number: C12M25/16 ,  B01J13/043 ,  Y10S530/813 ,  Y10S530/817

Abstract: Substances such as chemical substances and biological substances including animal, vegetable and microbial cells are encapsulated using a process and an apparatus wherein a coil through which alternating current flows causes a magnet to vibrate creating vibrations such as in the range of between 300 to 4000 Hz that are transmitted to an encapsulating fluid containing the substance to form small substantially spherical particles containing the substance. The apparatus includes a pulsation chamber containing a movable wall for receiving the encapsulating fluid containing the substance to be encapsulated. A nozzle is spaced downstream from the pulsation chamber for receiving the encapsulating fluid from the pulsation chamber. A permanent magnet is mounted on the movable wall, and a coil is spaced from the permanent magnet by an air gap and is located proximate to the permanent magnet. An alternating current source is connected to the coil for creating an alternating magnetic wave that causes vibration of the permanent magnet and wall attached thereto resulting in pulsing of the encapsulating fluid from the pulsation chamber through the nozzle to form the particles in which the substance is encapsulated.

Abstract translation: 诸如化学物质和生物物质（包括动物，植物和微生物细胞）的物质使用一种方法和装置来封装，其中交流电流流过的线圈导致磁体振动，产生振动，例如在300至4000Hz之间的范围内， 被传送到含有该物质的封装流体以形成含有该物质的小的基本上为球形的颗粒。 该装置包括脉动室，其包含用于接收含有待包封物质的封装流体的活动壁。 喷嘴与脉动室的下游间隔开，以从脉动室接收封装流体。 永磁体安装在可动壁上，线圈通过气隙与永久磁铁隔开并位于永磁体附近。 交流电源连接到线圈，用于产生交变磁波，引起永磁体和附着于其上的壁的振动，从而使来自脉动室的封装流体通过喷嘴脉冲形成物质被包封的颗粒 。

公开(公告)号：US6136364A

公开(公告)日：2000-10-24

申请号：US302596

申请日：1994-09-08

Applicant: Zohar M. Merchant ,  Vikki J. Nicholson

Inventor： Zohar M. Merchant ,  Vikki J. Nicholson

IPC: A23D7/04 ,  A23L27/00 ,  A23L27/20 ,  B01J13/04

CPC classification number: B01J13/043 ,  A23D7/04 ,  A23L27/206 ,  A23L27/72

Abstract: The present invention is directed to a method for producing a microcapsule flavor delivery system. In the method, a mixture of a flavoring material selected from the group consisting of an oil soluble flavor dissolved in an oil and an o/w emulsion flavor and a protein solution is provided. The mixture is subjected to low shear mixing to provide an o/w water pre-emulsion. The pre-emulsion is subjected to high shear mixing or sonication to provide an o/w emulsion having a coating of protein around the internal oil droplets. The o/w emulsion is mixed with a liquified hard fat which is solid at room temperature. The mixture of hard fat and o/w emulsion is atomized onto a planar surface or into a fluid to provide microcapsules which are an o/w/o multiple emulsion having a flavoring material in the internal oil phase or o/w emulsion.

Abstract translation: 本发明涉及一种微胶囊风味剂输送系统的制造方法。 在该方法中，提供选自由油中溶解的油性香料和o / w乳液香料组成的组的调味料与蛋白质溶液的混合物。 将混合物进行低剪切混合以提供o / w水预乳液。 将预乳液进行高剪切混合或超声处理以提供在内部油滴周围具有蛋白质涂层的o / w乳液。 将o / w乳液与在室温下为固体的液化硬脂混合。 将硬脂肪和o / w乳液的混合物雾化到平坦表面或流体中以提供微胶囊，其是在内部油相或o / w乳液中具有调味材料的o / w / o多重乳液。

公开(公告)号：US5945159A

公开(公告)日：1999-08-31

申请号：US764286

申请日：1996-12-12

Applicant: Joseph L. Sell

Inventor： Joseph L. Sell

IPC: B01J13/02 ,  B01J13/04 ,  B05D7/00

CPC classification number: B01J13/04 ,  B01J13/02 ,  B01J13/043

Abstract: The invention is directed to a method for the encapsulation of very finely divided solids within a continuous impervious coating of thermoplastic material. The method is carried out with continuous agitation during which the particles are coated with a plurality of sprayed layers of thermoplastic coating material while maintaining the particles in free-flowing powder consistency during the coating steps.

Abstract translation: 本发明涉及一种用于将非常细碎的固体包封在热塑性材料的连续不渗透涂层内的方法。 该方法在连续搅拌下进行，在此期间，颗粒被涂覆有多个喷涂热塑性涂层材料，同时在涂布步骤期间保持颗粒处于自由流动的粉末稠度。