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公开(公告)号：US09562108B2
公开(公告)日：2017-02-07
申请号：US14285579
申请日：2014-05-22
申请人： AMGEN INC.
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas Charles Boone , HoSung Min , Jane Talvenheimo , Taruna Arora , Frederick W. Jacobsen
IPC分类号： C07K16/44 , A61K39/395 , C07K16/00 , C07K16/18 , C07K14/435 , C07K14/575 , C07K14/605 , C07K16/24
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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公开(公告)号：US20120304337A1
公开(公告)日：2012-11-29
申请号：US13478515
申请日：2012-05-23
申请人： Ute Schellenberger , Jun-Zhi Wei , Genhai Zhu
发明人： Ute Schellenberger , Jun-Zhi Wei , Genhai Zhu
IPC分类号： A01N37/46 , C12N15/32 , A01N63/02 , A01P5/00 , C12N1/13 , C12N15/82 , A01H5/00 , A01H5/10 , C12N1/21 , C12N1/19 , C07K14/325 , C12N15/63
CPC分类号： C12N15/8285 , A01N63/02 , C07K14/325 , C07K14/66 , Y02A40/164
摘要： The invention provides novel δ-endotoxin polypeptides, and variants and fragments thereof, obtained from Bacillus thuringiensis having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant parasitic nematodes.
摘要翻译： 本发明提供了从苏云金芽孢杆菌获得的具有针对线虫杀虫活性的新颖的δ-内毒素多肽及其变体和片段。 本发明的具体实施方案提供编码杀虫蛋白，生物农药组合物，表达盒，以及包含本发明的核酸的转化的微生物和植物的分离的核酸。 这些组合物用于防治害虫，特别是植物寄生线虫的方法。
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公开(公告)号：US4505853A
公开(公告)日：1985-03-19
申请号：US553281
申请日：1983-11-18
申请人： Gideon Goldstein , George Heavner , Daniel Kroon , Tapan Audhya
发明人： Gideon Goldstein , George Heavner , Daniel Kroon , Tapan Audhya
IPC分类号： C07K5/10 , A61K38/00 , A61K38/22 , A61P5/00 , A61P37/00 , C07K1/113 , C07K7/06 , C07K14/52 , C07K14/54 , C07K14/66 , C07C103/52 , A61K37/00
CPC分类号： C07K14/662 , C07K14/66 , A61K38/00 , Y10S930/18
摘要： Peptides which have thymopoeitin-like or splenin-like activity combined with greatly increased resistance to degradation by enzymes. The peptides are useful for treatment of immunoregulatory disorders. Also provided are methods of treating immunoregulatory disorders and compositions used in these methods.
摘要翻译： 具有胸腺嘧啶样或脾素样活性的肽与大大提高的酶降解抗性相结合。 该肽可用于治疗免疫调节性疾病。 还提供了治疗免疫调节障碍的方法和用于这些方法的组合物。
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公开(公告)号：US4497801A
公开(公告)日：1985-02-05
申请号：US529646
申请日：1983-09-06
申请人： Masashi Hashimoto , Keiji Hemmi , Daijiro Hagiwara
发明人： Masashi Hashimoto , Keiji Hemmi , Daijiro Hagiwara
IPC分类号： A61K38/00 , C07K7/06 , C07K14/42 , C07K14/575 , C07K14/66 , A61K37/00 , C07C103/52
CPC分类号： C07K7/062 , C07K14/42 , C07K14/57581 , C07K14/66 , A61K38/00
摘要： Peptides of the following formulae:H-THR-LYS-GLU-LYS-LEU-LYS-SER-GLU-LEU-VAL-ALA-ASN-OH, H-GLU-LEU-LYS-SER-GLU-LEU-VAL-ALA-ASN-OH, H-LYS-LEU-LYS-SER-GLU-OH,are effective in the treatment of bacteria viral infection.
摘要翻译： 下式的肽：H-THR-LYS-GLU-LYS-LEU-LYS-SER-GLU-LEU-VAL-ALA-ASN-OH，H-GLU-LEU-LYS-SER-GLU-LEU-VAL- ALA-ASN-OH，H-LYS-LEU-LYS-SER-GLU-OH可有效治疗细菌病毒感染。
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公开(公告)号：US4215111A
公开(公告)日：1980-07-29
申请号：US020157
申请日：1979-03-14
申请人： Gideon Goldstein , George Heavner
发明人： Gideon Goldstein , George Heavner
IPC分类号： C07K5/04 , A61K38/00 , A61K38/22 , A61P37/00 , C07C235/72 , C07C237/10 , C07C237/22 , C07K5/06 , C07K5/072 , C07K5/083 , C07K5/103 , C07K7/06 , C07K14/66 , A61K37/00 , C07C103/52
CPC分类号： C07K7/06 , C07K14/66 , C07K5/06026 , C07K5/06104 , C07K5/0806 , C07K5/1008 , A61K38/00
摘要： Peptides of the following formula:A-Bwherein A is a member selected from the group consisting of deamino-GLN, GLN, and (SAR).sub.n -GLN; n is an integer from 1 to 4; and B is a member selected from the group consisting of LYS-OH, LYS-NH.sub.2, decarboxy-LYS, ##STR1## LYS-SAR-OH and LYS-SAR-NH.sub.2, have significantly increased ubiquitin-like activity. Also provided are therapeutic compositions and methods for use thereof.
摘要翻译： 下式的肽A-B其中A是选自deamino-GLN，GLN和（SAR）n-GLN的成员; n是1至4的整数; 并且B是选自LYS-OH，LYS-NH2，脱羧-LYS，图像LYS-SAR-OH和LYS-SAR-NH2的成员具有显着增加的泛素样活性。 还提供了治疗组合物及其使用方法。
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公开(公告)号：US09562107B2
公开(公告)日：2017-02-07
申请号：US14285576
申请日：2014-05-22
申请人： AMGEN INC.
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas Charles Boone , George Doellgast , HoSung Min , Jane Talvenheimo , Taruna Arora , Frederick W. Jacobsen
IPC分类号： C07K16/44 , A61K39/395 , C07K16/00 , C07K16/18 , C07K14/435 , C07K14/575 , C07K14/605 , C07K16/24
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
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公开(公告)号：US08734796B2
公开(公告)日：2014-05-27
申请号：US13258668
申请日：2010-03-19
申请人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , Janet Doellgast
发明人： Kenneth W. Walker , Yue-Sheng Li , Thomas C. Boone , Frederick W. Jacobsen , HoSung Min , Jane Talvenheimo , Taruna Arora , George Doellgast
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
摘要翻译： 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。
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公开(公告)号：US20120121591A1
公开(公告)日：2012-05-17
申请号：US13258454
申请日：2010-03-19
申请人： John K. Sullivan , Leslie P. Miranda , Colin V. Gegg , Shaw-Fen Sylvia Hu , Edward J. Belouski , Justin K. Murray , Hung Nguyen , Kenneth W. Walker , Taruna Arora , Frederick W. Jacobsen , Yue-Sheng Li , Thomas C. Boone
发明人： John K. Sullivan , Leslie P. Miranda , Colin V. Gegg , Shaw-Fen Sylvia Hu , Edward J. Belouski , Justin K. Murray , Hung Nguyen , Kenneth W. Walker , Taruna Arora , Frederick W. Jacobsen , Yue-Sheng Li , Thomas C. Boone
IPC分类号： A61K39/395 , C07K14/765 , C07K16/00 , C07K14/47 , C07K19/00 , A61K38/16 , A61P25/00 , A61P3/10 , A61P17/06 , A61P29/00 , A61P11/06 , A61P13/12 , A61P19/08 , A61K38/38 , A61K38/17 , A61P37/06 , A61P17/00 , A61P19/02 , A61P37/08 , A61P9/00 , A61P43/00 , C07K14/00
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed are compositions of matter having an amino acid sequence of SEQ ID NO:4, or a pharmaceutically acceptable salt thereof, including embodiments comprising a toxin peptide analog related to ShK, HmK, and AETX-K and pharmaceutical compositions or medicaments containing them along with a pharmaceutically acceptable carrier. Some embodiments include a half-life extending moiety. Also disclosed are a method of preventing or mitigating a relapse of a symptom of multiple sclerosis and a method of treating an autoimmune disorder using the compositions.
摘要翻译： 公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质组合物，包括包含与ShK，HmK和AETX-K相关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及 药学上可接受的载体。 一些实施方案包括半衰期延长部分。 还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。
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公开(公告)号：US5980913A
公开(公告)日：1999-11-09
申请号：US860008
申请日：1997-06-19
IPC分类号： A61K38/00 , A61K39/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/04 , C07K5/11 , C07K7/06 , C07K14/66 , A61K38/04 , A61K45/00
CPC分类号： C07K7/06 , C07K14/66 , C07K5/1019 , A61K38/00
摘要： The present invention relates to peptides having an immunomodulatory activity. The present invention is concerned with the tetrapeptide H-Lys-Asn-Pro-Tyr-OH (SEQ.ID NO:1) and analogues thereof as immunomodulators. The present invention also includes the use of such peptides as vaccine adjuvant.
摘要翻译： PCT No.PCT / CA95 / 00703 Sec。 371日期：1997年6月19日 102（e）日期1997年6月19日PCT 1995年12月15日PCT PCT。 WO96 / 19494 PCT出版物 日期1996年6月27日本发明涉及具有免疫调节活性的肽。 本发明涉及四肽H-Lys-Asn-Pro-Tyr-OH（SEQ ID NO：1）及其类似物作为免疫调节剂。 本发明还包括使用这样的肽作为疫苗佐剂。
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公开(公告)号：US4547489A
公开(公告)日：1985-10-15
申请号：US618968
申请日：1984-06-11
CPC分类号： C07K14/66 , A61K38/00 , Y10S930/18 , Y10S930/27
摘要： Immunoregulating peptides are disclosed which are cyclic peptides similar to thymopentin. These peptides are useful for their effects on the immune system, especially the treatment of thymic deficiencies.
摘要翻译： 公开了与胸腺五肽相似的环肽的免疫调节肽。 这些肽可用于对免疫系统的影响，特别是对胸腺缺陷的治疗。
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