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    Immunogenic anaplasma marginale surface antigens, compositions, and methods of use
    14.
    发明授权
    Immunogenic anaplasma marginale surface antigens, compositions, and methods of use 失效
    免疫原性阿片样物质表面抗原，组合物和使用方法

    公开(公告)号：US5549898A

    公开(公告)日：1996-08-27

    申请号：US228180

    申请日：1994-04-15

    申请人： Travis C. McGuire ,  Guy H. Palmer ,  Anthony F. Barbet ,  William C. Davis

    发明人： Travis C. McGuire ,  Guy H. Palmer ,  Anthony F. Barbet ,  William C. Davis

    IPC分类号： A61K39/00 ,  C07K14/29 ,  C07K16/12 ,  A61K39/002 ,  A61K39/005 ,  A61K39/018

    CPC分类号： C07K16/1246 ,  C07K14/29 ,  A61K39/00

    摘要： A purified antigenic surface protein of Anaplasma marginale has been identified, and is capable of inducing immune responses in ruminants which neutralizes virulent Anaplasma marginale. The antigenic surface protein has a molecular weight of about 105,000 daltons, and can be purified by an immunoaffinity chromatography process. The antigen has further utility in diagnostic tests for anaplasmosis. It can be synthesized by polypeptide procedures or by genetic engineering. DNA and amino acid sequences have been developed for the antigen according to this invention. The antigen is useful as a vaccine component for protecting mammals against infection by Anaplasma marginale and may be useful for rickettsial organisms other than Anaplasma marginale.

    摘要翻译： 已经鉴定了Anaplasma limale的纯化抗原表面蛋白，并且能够诱导反刍动物中的免疫应答，其中和有毒的Anaplasma limale。 抗原表面蛋白具有约105,000道尔顿的分子量，并且可以通过免疫亲和层析方法纯化。 该抗原在用于去斑疹的诊断测试中具有进一步的用途。 它可以通过多肽程序或基因工程来合成。 针对本发明的抗原已经开发了DNA和氨基酸序列。 该抗原可用作用于保护哺乳动物抵抗阿片平滑感染的疫苗组分，并且可用于除了阿布拉斯氏病以外的立克次体生物体。

    Compositions of and method of using heat shock protein peptides
    18.
    发明授权
    Compositions of and method of using heat shock protein peptides 有权
    使用热休克蛋白肽的组成和方法

    公开(公告)号：US08685406B2

    公开(公告)日：2014-04-01

    申请号：US12927220

    申请日：2010-11-10

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： A61K39/02 ,  C07K16/00

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。