利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.009 秒)

    ML-236B Derivatives
    12.
    发明授权
    ML-236B Derivatives 失效
    ML-236B衍生物

    公开(公告)号：US4448979A

    公开(公告)日：1984-05-15

    申请号：US351975

    申请日：1982-02-24

    申请人： Akira Terahara ,  Minoru Tanaka

    发明人： Akira Terahara ,  Minoru Tanaka

    IPC分类号： C07C69/03 ,  C07D309/30 ,  C12P7/62 ,  C12P17/06

    CPC分类号： C12R1/465 ,  C07D309/30 ,  C12P17/06 ,  C12P7/62 ,  C12R1/645 ,  C12R1/65 ,  C12R1/785 ,  C12R1/845 ,  Y10S435/886

    摘要： Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.

    摘要翻译： 式（I）的化合物：其中R表示式（Ⅰ）的基团或相应的闭环内酯，盐（特别是碱金属盐）和酯（特别是C 1 -C 5） 烷基酯）可以通过使ML-236B或ML-236B羧酸或其盐或酯进行酶羟基化来制备，其可以通过毛霉属，根霉属，丝状芽孢杆菌属，圆弧菌属，放线菌属， Gongronella，Phycomyces，Martierella，Pycnoporus，Rhizoctonia，Absidia，Cunninghamella，Syncephalastrum和Streptomyces，或来自所述微生物的无细胞的含酶提取物，这些化合物能够抑制胆固醇的生物合成，因此可用于治疗高胆固醇血症。

    ML-236B Derivatives and their preparation
    13.
    发明授权
    ML-236B Derivatives and their preparation 失效
    ML-236B衍生物及其制备方法

    公开(公告)号：US4346227A

    公开(公告)日：1982-08-24

    申请号：US270846

    申请日：1981-06-05

    申请人： Akira Terahara ,  Minoru Tanaka

    发明人： Akira Terahara ,  Minoru Tanaka

    IPC分类号： C07C69/03 ,  C07D309/30 ,  C12P7/62 ,  C12P17/06 ,  C07C69/013

    CPC分类号： C12R1/465 ,  C07D309/30 ,  C12P17/06 ,  C12P7/62 ,  C12R1/645 ,  C12R1/65 ,  C12R1/785 ,  C12R1/845 ,  Y10S435/886

    摘要： Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C.sub.5 alkyl esters) thereof may be prepared by subjecting ML-236B, or ML-236B carboxylic acid or a salt or ester thereof to enzymatic hydroxylation, which may be effected by means of microorganisms of the genera Mucor, Rhizopus, Zygorynchus, Circinella, Actinomucor, Gongronella, Phycomyces, Martierella, Pycnoporus, Rhizoctonia, Absidia, Cunninghamella, Syncephalastrum and Streptomyces, or cell-free, enzyme-containing extracts from said microorganisms. The compounds are capable of inhibiting biosynthesis of cholesterol and are thus useful in the treatment of hypercholesteraemia.

    摘要翻译： 式（I）的化合物：其中R表示式（Ⅰ）的基团和相应的闭环内酯，盐（特别是碱金属盐）和酯（特别是C 1 -C 5烷基 酯）可以通过使ML-236B或ML-236B羧酸或其盐或酯进行酶羟基化来制备，其可以通过毛霉属，根霉属，Zygorynchus，Circinella，Actinomucor，Gongronella ，Phycomyces，Martierella，Pycnoporus，Rhizoctonia，Absidia，Cunninghamella，Syncephalastrum和Streptomyces，或来自所述微生物的无细胞的含酶提取物，这些化合物能够抑制胆固醇的生物合成，因此可用于治疗高胆固醇血症。