公开(公告)号：US4230878A

公开(公告)日：1980-10-28

申请号：US884673

申请日：1978-03-08

Applicant: Robert G. Shepherd

Inventor： Robert G. Shepherd

IPC: C07C17/093 ,  C07C45/45 ,  C07C323/25 ,  C07C327/22 ,  C07D207/34 ,  C07D207/42 ,  C07D211/46 ,  C07D213/30 ,  C07D213/65 ,  C07D213/80 ,  C07D239/42 ,  C07D263/10 ,  C07D265/06 ,  C07D277/06 ,  C07D303/16 ,  C07D307/54 ,  C07D307/66 ,  C07D307/68 ,  C07D307/71 ,  C07D309/12 ,  C07D317/28 ,  C07D333/16 ,  C07D333/20 ,  C07D333/22 ,  C07D333/24 ,  C07D333/36 ,  C07D333/38 ,  C07D333/44 ,  C07C101/62 ,  C07C101/60

CPC classification number: C07D213/30 ,  C07C17/093 ,  C07C323/25 ,  C07C327/22 ,  C07C45/45 ,  C07D207/34 ,  C07D207/42 ,  C07D211/46 ,  C07D213/65 ,  C07D213/80 ,  C07D239/42 ,  C07D263/10 ,  C07D265/06 ,  C07D277/06 ,  C07D303/16 ,  C07D307/54 ,  C07D307/66 ,  C07D307/68 ,  C07D307/71 ,  C07D309/12 ,  C07D317/28 ,  C07D333/16 ,  C07D333/20 ,  C07D333/22 ,  C07D333/24 ,  C07D333/36 ,  C07D333/38 ,  C07D333/44 ,  Y10S514/824

Abstract: This disclosure describes 4-[(unsaturated or cyclopropylated alkyl)amino]benzoic acids and derivatives useful as hypolipidemic and antiatherosclerotic agents.

Abstract translation: 本公开描述了用作降血脂和抗动脉粥样硬化剂的4 - [（不饱和或环丙基烷基）氨基]苯甲酸和衍生物。

公开(公告)号：US4052419A

公开(公告)日：1977-10-04

申请号：US580900

申请日：1975-05-27

Applicant: Solomon Aronovich Giller ,  Karl Karlovich Venter ,  Margarita Aldonovna Trushule ,  Guntis Erikovich Berggrin ,  Robert Avgustovich Brinkmanis ,  Uldis Yanovich Mikstais ,  Paul Alexandrovich Stankevich

Inventor： Solomon Aronovich Giller ,  Karl Karlovich Venter ,  Margarita Aldonovna Trushule ,  Guntis Erikovich Berggrin ,  Robert Avgustovich Brinkmanis ,  Uldis Yanovich Mikstais ,  Paul Alexandrovich Stankevich

IPC: C07D307/71

CPC classification number: C07D307/71

Abstract: A method of preparing 5-nitrofurfural diacetate which comprises nitration furfural or furfural diacetate at a temperature within the range of from -10.degree. to +10.degree. C; said nitration being effected by the gradual simultaneous addition of furfural or a furfural diacetate solution in acetic anhydride and a mixture of nitric and sulphuric acids into acetic anhydride at a temperature within the range of from -10.degree. to +10.degree. C under continuous stirring of the reaction mixture. In doing so, molar proportions of furfural or furfural diacetate and nitric acid and sulphuric acid are maintained equal to 1:1.1-2:0.036-0.041 respectively and said compounds are added into acetic anhydride at such rates as to maintain the nitration reaction temperature at a predetermined level. The reaction mixture resulting from the nitration is treated with water at a weight ratio between water and the starting acetic anhydride ranging from 1.1:1 to 1.8:1 respectively and at a temperature within the range of from 0.degree. to 15.degree. C; the reaction mixture is then neutralized with an alkali to a pH = 3.5 - 5 at a temperature within the range of from 0.degree. to 25.degree. C, maintained at a temperature of from 45.degree. to 55.degree. C, and the desired product is thereafter isolated from said reaction mixture.

公开(公告)号：US4051253A

公开(公告)日：1977-09-27

申请号：US621529

申请日：1975-10-10

Applicant: Helmut Hein ,  Rosmarie Hermann geb Gleissner ,  Hartmann Schaefer

Inventor： Helmut Hein ,  Rosmarie Hermann geb Gleissner ,  Hartmann Schaefer

IPC: C07C243/38 ,  C07D307/71 ,  C07D307/75 ,  C07F9/54 ,  A01N9/28 ,  C07D307/34

CPC classification number: C07C243/38 ,  C07D307/71 ,  C07D307/75 ,  C07F9/5456

Abstract: 2-[(O-ALKYLAROYLHYDRAZONO)PROPEN-1-YL]-5-NITROFURANS [1] ARE PREPARED BY CONDENSING 3-(5-NITRO-2-FURYL)ACRYLALDEHYDE [2] WITH AN O-ALKYLAROYL HYDRAZIDE [3]. Compounds [1] are bactericides, protozoacides and fungicides and are administrable to animals in therapeutically-acceptable compositions.

公开(公告)号：US3928413A

公开(公告)日：1975-12-23

申请号：US41280673

申请日：1973-11-05

Applicant: ZOECON CORP

Inventor： HENRICK CLIVE A ,  STAAL GERARDUS B

IPC: C07D213/30 ,  C07D213/79 ,  C07D307/54 ,  C07D307/71 ,  C07D333/38 ,  C09F5/08 ,  C07C69/76

CPC classification number: C07D213/30 ,  C07D213/79 ,  C07D307/54 ,  C07D307/71 ,  C07D333/38 ,  C09F5/08

Abstract: Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

Abstract translation: 特征在于存在环丙烷部分，其合成及其组合物用于控制螨虫和蜱的有机酯和硫酯。

公开(公告)号：US3864117A

公开(公告)日：1975-02-04

申请号：US15695771

申请日：1971-06-25

Applicant: MERCK PATENT GMBH

Inventor： GANTE JOACHIM ,  SCHNEIDER GERHART

IPC: A01N37/10 ,  A01N37/34 ,  A01N37/38 ,  A01N37/48 ,  A01N43/08 ,  A01N47/48 ,  C07C57/58 ,  C07C69/76 ,  C07D307/54 ,  C07D307/56 ,  C07D307/71 ,  A01N9/24

CPC classification number: C07D307/56 ,  C07C57/58 ,  C07C327/00 ,  C07D307/54 ,  C07D307/71

Abstract: Compounds of the formula
AND DERIVATIVES THEREOF, INCLUDING ESTERS, THIOESTERS, AND AMMONIUM AND METAL SALTS THEREOF, WHEREIN R1 is aryl, unsubstituted 2-furyl or 2-furyl substituted at the 5-position by halogen or NO2; R2 and R3 are H or CH3 and X is Cl or Br, are selective defoliating herbicides useful to control weeds in agriculture and horticulture, e.g., cultivation of corn, rice and cotton.

Abstract translation: 式中的化合物及其衍生物，包括酯，硫代和其铵和金属盐，其中R1是在5位被卤素或NO 2取代的芳基，未被取代的2-呋喃基或2-呋喃基; R2和R3是H或CH3，X是Cl或Br，是用于控制农业和园艺杂草的选择性脱叶除草剂，例如玉米，水稻和棉花的种植。

公开(公告)号：US3830813A

公开(公告)日：1974-08-20

申请号：US24141472

申请日：1972-04-05

Applicant: BOEHRINGER SOHN INGELHEIM

Inventor： WOITUM E ,  REUTER W

IPC: C07D307/34 ,  C07D239/70 ,  C07D239/74 ,  C07D307/71 ,  C07D333/50 ,  C07D495/04

CPC classification number: C07D495/04 ,  Y02P20/55

Abstract: COMPOUNDS OF THE FORMULA

2-(5-(O2N-)-FUR-2-YL),4-R,5-R1,6-R2-THIENO(2,3-D)PYRIMI

DINE

WHEREIN R IS FREE AMINO; LOWER ALIPHATIC ACYLAMINO OPTIONALLY MONO- OR DI-CHLORO-SUBSTITUTED ON THE ACYL MOIETY; (STRAIGHT OR BRANCHED MONOALKYL OF 1 TO 5 CARBON ATOMS)-AMINO; DI(AKYL OF 1 TO 4 CARBON ATOMS)AMINO, WHERE THE ALKYL MOIETIES MA BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER; MONO- OR DI-HYDROXY (STRAIGHT OR BRANCHED ALKYL OF 1 TO 5 CARBON ATOMS) AMINO, WHERE THE ATOMS SUBSTITUENT ATTACHED AN ALKYL OF 1 TO 4 CARBON ATOMS SUBSTITUENT ATTACHED THERETO; DI-(HYDROXY (STRAIGHT OR BRANCHED ALKYL OF 1 TO 3 CARBON ATOMS) AMINO; ALKOXY OF 1 TO 2 CARBON ATOMS (ALKYL OF 1 TO 3 CARBON ATOMS)AMINO; FREE AMINO (ALKYL OF 1 TO 3 CARBON ATOMS)AMINO; N-ACETYL-(ALKYLENE OF 1 TO 3 CARBON ATOMS)-DIAMINO; PIPERIDINO; OR HYDROXY-PIPERIDINO; AND R1 AND R2 WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN, METHYL OR ETHYL. AND NON-TOXIC, PHARMACOLOGICALLY ACCEPATABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS BACTERICIDES, FUNGICIDES AND TRICHOMONACIDES.

公开(公告)号：US3716531A

公开(公告)日：1973-02-13

申请号：US3716531D

申请日：1968-10-31

Applicant: SCHERING AG ,  SCHROEDER E ,  ALBRECHT R

Inventor： ALBRECHT R ,  SCHRODER E ,  MUFTIC M

IPC: C07D207/42 ,  C07D307/71 ,  C07D333/44 ,  C07D5/30

CPC classification number: C07D207/42 ,  C07D307/71 ,  C07D333/44

Abstract: For combating and preventing infections caused by a variety of microbes such as bacteria and Trichomonas vaginalis, new compounds of the formula
WHEREIN X is O, S or NH; Y is O; S; -CH2-O-; -S-CH2-; -CH2-S-; -O-CH2-; -SO-; -SO-CH2-; CH2-SO-; -CH2-SO2-; -SO2-CH2- or -CA2-, A being H, methyl, ethyl or phenyl; and R1, R2 and R3 each represents alkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyalkoxy, mono- or dialkylaminoalkyl, dialkylaminoalkoxy, amino, acylamino, mono- or dialkylamino, alkylsulfonylamino, acyloxy, alkylsulfonyloxy, benzyloxy groups wherein each alkyl, alkoxy or acyl residue is not more than five carbon atoms and acyl is derived from a carboxylic acid; halogen; or hydrogen with the provision that when Y represents -CH2-, at least one of R1, R2, and R3 is other than hydrogen.

Abstract translation: 为了防治由各种微生物（如细菌和阴道毛滴虫）引起的感染，式WHEREIN X的新化合物是O，S或NH; Y是O; S; -CH 2 -O-; -S-CH 2 - ; -CH 2 -S-; -O-CH 2 - ; -所以-; -SO-CH 2 - ; -CH 2 -SO-; -CH 2 -SO 2 - ; -SO 2 -CH 2 - 或-CA 2 - ，A为H，甲基，乙基或苯基; R1，R2和R3各自表示烷基，羟基，羟烷基，烷氧基，烷氧基烷基，烷氧基烷氧基，一或二烷基氨基烷基，二烷基氨基烷氧基，氨基，酰氨基，一烷基氨基或二烷基氨基，烷基磺酰氨基，酰氧基，烷基磺酰氧基，苄氧基，其中各烷基，烷氧基或 酰基残基不超过5个碳原子，酰基衍生自羧酸; 卤素; 或氢，条件是当Y表示-CH 2 - 时，R 1，R 2和R 3中的至少一个不是氢。

公开(公告)号：US3260716A

公开(公告)日：1966-07-12

申请号：US30700663

申请日：1963-09-06

Applicant: TOYAMA KAGAKU KOGYO KABUSHIKI

Inventor： AKIRA TAKAI ,  ISAMU SAIKAWA ,  TOYOO MAEDA ,  YUTAKA KODAMA ,  IKUKO TAKAMICHI ,  YASUMASA MATSUBARA ,  SHIRO HIRAI

IPC: C07D307/71 ,  C07D413/06

CPC classification number: C07D413/06 ,  C07D307/71

公开(公告)号：US3047587A

公开(公告)日：1962-07-31

申请号：US2854460

申请日：1960-05-12

Applicant: ABBOTT LAB

Inventor： SHERMAN WILLIAM R

IPC: C07D307/71

CPC classification number: C07D307/71

公开(公告)号：US20190247391A1

公开(公告)日：2019-08-15

申请号：US16396829

申请日：2019-04-29

Applicant: The Penn State Research Foundation

Inventor： Wafik S. El-Deiry ,  Shengliang Zhang

IPC: A61K31/496 ,  C07D307/71

Abstract: The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.