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公开(公告)号:US4536346A
公开(公告)日:1985-08-20
申请号:US492094
申请日:1983-05-06
IPC分类号: A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61P9/10 , C07C33/24 , C07C51/347 , C07C51/36 , C07C57/30 , C07C57/38 , C07C57/58 , C07C57/60 , C07C57/72 , C07C57/76 , C07C59/64 , C07C59/88 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/11 , C07C233/12 , C07C233/15 , C07C233/53 , C07C235/38 , C07C253/00 , C07C255/58 , C07C255/60 , C07C301/00 , C07C303/40 , C07C311/46 , C07F9/38 , C07C121/78 , C07C101/44
CPC分类号: C07C255/00 , C07C233/11 , C07C33/24 , C07C51/347 , C07C51/36 , C07C57/30 , C07C57/38 , C07C57/58 , C07C57/60 , C07C57/72 , C07C57/76 , C07C59/64 , C07C59/88 , C07F9/3808
摘要: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
摘要翻译: 本公开描述了新的取代的芳烷酰胺基苯甲酸及其类似物。 这些化合物是通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的有用的药剂。
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公开(公告)号:US4489090A
公开(公告)日:1984-12-18
申请号:US492097
申请日:1983-05-06
IPC分类号: C07D335/14 , A61K31/22 , A61K31/38 , C07C103/733 , C07D335/12
CPC分类号: C07D335/14 , Y10S514/824
摘要: This disclosure describes novel dibenzocycloalkanamido-benzoic acids and esters. Also described are dibenzothioxanthenyl-benzoic acids and esters. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
摘要翻译: 本公开描述了新的二苯并环烷酰氨基 - 苯甲酸和酯。 还描述了二苯并噻二苯并苯甲酸和酯。 这些化合物是通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的有用的药剂。
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公开(公告)号:US4439606A
公开(公告)日:1984-03-27
申请号:US375507
申请日:1982-05-06
申请人: Mila T. Du , Robert G. Shepherd
发明人: Mila T. Du , Robert G. Shepherd
IPC分类号: C07D295/18 , A61K31/495 , A61P9/10 , C07D213/38 , C07D215/38 , C07D241/20 , C07D241/44 , C07D277/20 , C07D277/42 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D401/04
CPC分类号: C07D215/38 , C07D213/38 , C07D241/20 , C07D241/44 , C07D277/42 , C07D295/185 , C07D401/06 , Y10S514/824
摘要: This disclosure describes 4-aryl, -heteroaryl and -heteroarylmethyl-1-piperazinecarbonyl compounds which are capable of ameliorating atherosclerosis in mammals.
摘要翻译: 本公开描述了能够改善哺乳动物动脉粥样硬化的4-芳基 - 杂芳基和 - 杂芳基甲基-1-哌嗪羰基化合物。
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4.Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds 失效
标题翻译: 降血脂和抗动脉粥样硬化4-(多氟 - 烷基氨基)苯基化合物公开(公告)号:US4305959A
公开(公告)日:1981-12-15
申请号:US93767
申请日:1979-11-13
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/093 , C07C45/45 , C07C323/25 , C07C327/22 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/30 , C07D213/65 , C07D213/80 , C07D233/54 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , A01N33/02 , C07C87/60
CPC分类号: C07D213/30 , C07C17/093 , C07C323/25 , C07C327/22 , C07C45/45 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/65 , C07D213/80 , C07D233/64 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , Y10S514/824
摘要: This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了可用作降血脂和抗动脉粥样硬化剂的新型4-(多氟烷基氨基)苯基化合物。
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5.Benzaldehydes, alkanophenones, and benzophenones and derivatives thereof containing a 4-monoalkylamino group 失效
标题翻译: 苯甲醛,烷基苯醌和二苯甲酮及其衍生物含有4-单烷基氨基公开(公告)号:US4273785A
公开(公告)日:1981-06-16
申请号:US836947
申请日:1977-09-27
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C45/45 , C07C275/54 , C07D257/04 , C07D295/192 , A61K31/135 , A61K31/205 , C07C95/08
CPC分类号: C07D257/04 , C07C275/54 , C07C45/45 , C07D295/192 , Y10S514/824
摘要: Novel 4-monoalkylamino-benzaldehydes, 4-mono-alkylamino-alkanophenones, and 4-monoalkylamino-benzophenones, and derivatives and salts thereof, are disclosed which are useful as anti-atherosclerotic agents.
摘要翻译: 公开了新的4-单烷基氨基 - 苯甲醛,4-单烷基氨基 - 亚烷基苯甲酸和4-单烷基氨基 - 二苯甲酮及其衍生物和盐,其可用作抗动脉粥样硬化剂。
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公开(公告)号:US4260816A
公开(公告)日:1981-04-07
申请号:US59915
申请日:1979-07-20
IPC分类号: C07C59/68 , C07C309/66 , C07D333/16 , C07D333/20 , C07C101/60 , C07C101/58
CPC分类号: C07C59/68 , C07C309/66 , C07D333/16 , C07D333/20 , Y10S514/866
摘要: This disclosure describes pharmaceutical compositions having hypolipidemic and/or hypoglycemic activity which contain a substituted naphthyloxyalkylaminobenzoic acid or salt or ester thereof.
摘要翻译: 本公开内容描述了含有取代的萘甲氧基烷基氨基苯甲酸或其盐或酯的具有降血脂和/或降血糖活性的药物组合物。
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公开(公告)号:US4242273A
公开(公告)日:1980-12-30
申请号:US950899
申请日:1978-10-12
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/26 , C07C45/45 , C07C243/38 , C07C273/18 , C07C275/54 , C07D207/40 , C07D207/404 , C07D263/10 , C07D265/08 , C07D277/06 , C07D295/192 , C07C143/52 , C07C97/10 , C07C101/42 , C07C103/22
CPC分类号: C07D207/404 , C07C17/26 , C07C243/38 , C07C273/1854 , C07C275/54 , C07C45/45 , C07D263/10 , C07D265/08 , C07D277/06 , C07D295/192
摘要: This disclosure describes 4-(monoalkylamino)benzoic acid amides and imidates useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了用作降血脂和抗动脉粥样硬化剂的4-(单烷基氨基)苯甲酸酰胺和亚胺化物。
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8.4-[(Carboxyl- and sulfamyl-substituted alkyl)-amino] benzoic acids and analogs 失效
标题翻译: 4 - [(羧基 - 和磺酰氨基取代的烷基) - 氨基]苯甲酸和类似物公开(公告)号:US4230628A
公开(公告)日:1980-10-28
申请号:US895574
申请日:1978-04-12
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/093 , C07C45/45 , C07C323/25 , C07C327/22 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/30 , C07D213/65 , C07D213/80 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , C07C101/44
CPC分类号: C07D213/30 , C07C17/093 , C07C323/25 , C07C327/22 , C07C45/45 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/65 , C07D213/80 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44
摘要: This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了可用作降血脂和抗动脉粥样硬化剂的新型4 - [(羧基和磺酰氨基取代的烷基)氨基]苯甲酸和类似物。
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9.Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives 失效
标题翻译: 抗血脂对 - (芳基(烷基或烯基)氨基] - 苯甲酸衍生物公开(公告)号:US4185115A
公开(公告)日:1980-01-22
申请号:US557550
申请日:1975-03-12
IPC分类号: A61K31/19 , A61K31/195 , A61K31/196 , A61K31/245 , A61P3/06 , C07C29/147 , C07C67/00 , C07C219/34 , C07C227/00 , C07C229/60 , C07C309/66 , C07D333/16 , C07D333/20 , C07C101/60 , C07C101/62
CPC分类号: C07D333/20 , C07C29/147 , C07C309/66 , C07D333/16
摘要: Novel para-[aryl(alkyl or alkenyl)amino]benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum lipid levels in mammals therewith.
摘要翻译: 新型对 - [芳基(烷基或烯基)氨基]苯甲酸,酯,药学上可接受的盐和药物组合物,以及降低哺乳动物血清脂质水平的方法。
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10.
公开(公告)号:US4531503A
公开(公告)日:1985-07-30
申请号:US581535
申请日:1984-02-21
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
摘要: A single-action, gas powered repeating pistol has a sliding unitary barrel and hammer assembly with the barrel and hammer aligned on opposite sides of a fixed pressure chamber. In the uncocked condition, the hammer extends rearwardly of the main frame so that cocking may be effected by merely slapping the rear of the hammer to force the assembly forward to be retained by a trigger mounted sear.
摘要翻译: 单作用,气动重复手枪具有滑动的单体桶和锤组件,其中桶和锤在固定压力室的相对侧对齐。 在未锁定状态下,锤从主框架向后延伸,使得可以通过仅拍打锤的后部来迫使组件向前以由扳机安装的掣子保持而进行起跳。
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