公开(公告)号：US20040030098A1

公开(公告)日：2004-02-12

申请号：US10403847

申请日：2003-03-28

发明人： Liana M. Lee ,  John N. Feder ,  Nathan O. Siemers ,  Shujian Wu

IPC分类号： C07H021/04 ,  C07K014/705 ,  C07K016/30 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/70503

摘要： The present invention provides novel polynucleotides encoding BGS-5G, and BGS-5I polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-5G, and BGS-5I polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码BGS-5G和BGS-5I多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-5G和BGS-5I多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20040029222A1

公开(公告)日：2004-02-12

申请号：US10218779

申请日：2002-08-14

发明人： Shlomit R. Edinger ,  John R. MacDougall ,  Isabelle Millet ,  Karen Ellerman ,  David J. Stone ,  Valerie Gerlach ,  William M. Grosse ,  John P. Alsobrook II ,  Denise M. Lepley ,  Danier K. Rieger ,  Catherine E. Burgess ,  Stacie J. Casman ,  Kimberly A. Spytek ,  Ference L. Boldog ,  Li Li ,  Muralidhara Padigaru ,  Vishnu Mishra ,  Meera Patturajan ,  Suresh G. Shenoy ,  Luca Rastelli ,  Velizar T. Tchernev ,  Corine A.M. Vernet ,  Bryan D. Zerhusen ,  Uriel M. Malyankar ,  Xiaojia (Sasha) Guo ,  Charles E. Miller ,  Esha A. Gangolli ,  Michael Grosse

IPC分类号： C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/30

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/47

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20040029195A1

公开(公告)日：2004-02-12

申请号：US10333543

申请日：2003-08-25

发明人： Ramin Shiekhattar

IPC分类号： G01N033/574 ,  A61K039/395 ,  C07K016/30

CPC分类号： G01N33/57484

摘要： Methods for screening for cancer are provided which are based on the direct interaction of BRCA1 with the mammalian SWI/SNF complex through association with its BRG1 subunit. Also provided are compositions for modulating cellular proliferation by modulating chromatin remodeling activity in mammalian cells which targets a BRG1 subunit of the SWI/SNF complex.

摘要翻译： 提供了筛选癌症的方法，其基于通过与其BRG1亚基相关联的BRCA1与哺乳动物SWI / SNF复合物的直接相互作用。 还提供了通过调节靶向SWI / SNF复合物的BRG1亚基的哺乳动物细胞中的染色质重塑活性来调节细胞增殖的组合物。

公开(公告)号：US20040009491A1

公开(公告)日：2004-01-15

申请号：US10264237

申请日：2002-10-04

发明人： Charles E. Birse ,  Craig A. Rosen

IPC分类号： C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K016/30 ,  C07K014/705

CPC分类号： C07K14/47

摘要： The present invention relates to novel polynucleotides associated with the plasma membrane, the polypeptides encoded by these polynucleotides herein collectively referred to as nullplasma membrane associated antigens,null and antibodies that immunospecifically bind these polypeptides, and the use of such plasma membrane associated polynucleotides, antigens, and antibodies for detecting, treating, preventing and/or prognosing disorders related to these novel polypeptides. More specifically, isolated nucleic acid molecules are provided encoding novel plasma membrane associated polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing these plasma membrane associated polynucleotides, polypeptides, and/or antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the novel polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The invention further relates to methods and/or compositions for inhibiting or promoting the production and/or function of the polypeptides of the invention.

摘要翻译： 本发明涉及与质膜相关的新型多核苷酸，由这些多核苷酸编码的多肽本文统称为“质膜相关抗原”，以及免疫特异性结合这些多肽的抗体，以及使用这种质膜相关多核苷酸，抗原 以及用于检测，治疗，预防和/或预测与这些新型多肽相关的疾病的抗体。 更具体地，提供编码新型质膜相关多肽的分离的核酸分子。 提供结合这些多肽的新型多肽和抗体。 还提供了用于产生这些质膜相关多核苷酸，多肽和/或抗体的载体，宿主细胞和重组和合成方法。 本发明还涉及用于诊断，治疗，预防和/或预测与本发明的新型多肽相关的疾病的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制或促进本发明多肽的产生和/或功能的方法和/或组合物。

公开(公告)号：US20040006212A1

公开(公告)日：2004-01-08

申请号：US10374531

申请日：2003-02-25

发明人： Neil I. Goldstein ,  Nicholas A. Giorgio ,  Steven Tarran Jones ,  Jose William Saldanha

IPC分类号： C07K016/30

CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2319/00

摘要： Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.

摘要翻译： 抗EGF受体抗体225的嵌合和人源化形式及其片段用于治疗肿瘤。

公开(公告)号：US20040005645A1

公开(公告)日：2004-01-08

申请号：US10393992

申请日：2003-03-24

申请人： The Regents of the University of Michigan

发明人： Samir M. Hanash ,  David G. Beer ,  Rork Kuick ,  Robert Hinderer

IPC分类号： G01N033/574 ,  C07H021/04 ,  C07K014/475 ,  C07K016/30

CPC分类号： G01N33/57488 ,  G01N33/57407

摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.

摘要翻译： 来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。

公开(公告)号：US20030228592A1

公开(公告)日：2003-12-11

申请号：US10367980

申请日：2003-02-19

申请人： St. Vincent's Institute of Medical Research

发明人： Suzanne Dawn Rogers ,  James Donovan Best

IPC分类号： A61K051/00 ,  C12Q001/68 ,  G01N033/574 ,  A61K031/70 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/705 ,  C07K016/30

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/62

摘要： The present invention relates to a novel glucose transporter protein isolated from a breast cancer cell line, and to the gene encoding the protein. Detection of expression of the protein is useful as a diagnostic and staging marker in cancer. Control of expression of the protein is useful in the therapy of cancer. Furthermore, up-regulation of the protein is useful to overcome insulin resistance in non-insulin dependent diabetes mellitus.

摘要翻译： 本发明涉及从乳腺癌细胞系分离的新型葡萄糖转运蛋白，以及编码该蛋白质的基因。 检测蛋白质的表达可用作癌症中的诊断和分期标志物。 控制蛋白质的表达可用于治疗癌症。 此外，蛋白质的上调可用于克服非胰岛素依赖性糖尿病中的胰岛素抵抗。

公开(公告)号：US20030224462A1

公开(公告)日：2003-12-04

申请号：US10162133

申请日：2002-06-04

发明人： George H. Parsons

IPC分类号： G01N033/574 ,  C07K016/30

CPC分类号： G01N33/574 ,  G01N33/6854

摘要： The invention relates to new immunoassays using IgE type auto-antibodies specific for tumor antigens, especially prostate specific antigen (PSA). Such an assay can also be used to improve existing assays for PSA.

摘要翻译： 本发明涉及使用针对肿瘤抗原特异性的IgE型自身抗体的新免疫测定法，特别是前列腺特异性抗原（PSA）。 这样的测定法也可用于改进PSA的现有测定。

公开(公告)号：US20030211520A1

公开(公告)日：2003-11-13

申请号：US10334561

申请日：2002-12-30

发明人： Daniel E. Afar ,  Rene S. Hubert ,  Stephen Chappell Mitchell

IPC分类号： C12Q001/68 ,  G01N033/574 ,  A61K039/395 ,  A61K039/00 ,  C07K014/47 ,  C12P021/02 ,  C12N005/06 ,  C07K016/30

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00 ,  Y02A50/466 ,  Y10S977/91 ,  Y10S977/916 ,  Y10S977/924

摘要： A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in human prostate tumors, in some cases at high levels. A full length cDNA encoding 22P4F11 is provided. The 22P4F11 transcript and/or protein may represent a useful diagnostic marker and/or therapeutic target for prostate cancer.

摘要翻译： 描述了在人前列腺癌中表达的新型睾丸特异性基因，命名为22P4F11。 正常前列腺，前列腺肿瘤异种移植物和各种正常组织中22P4F11 mRNA表达的分析表明，该基因的表达在正常组织中是睾丸特异性的。 22P4F11基因也在人前列腺肿瘤中表达，在某些情况下也是高水平表达的。 提供了编码22P4F11的全长cDNA。 22P4F11转录物和/或蛋白质可以代表前列腺癌的有用的诊断标记物和/或治疗靶标。

公开(公告)号：US20030206916A1

公开(公告)日：2003-11-06

申请号：US10138469

申请日：2002-05-03

申请人： Rush-Presbyterian-St. Luke's Medical Center

发明人： Joo-Eun Bae ,  Hans-G. Klingemann

IPC分类号： A61K039/00 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/30 ,  C12N005/08

CPC分类号： C07K14/70596 ,  A61K39/00 ,  A61K2039/5154

摘要： The invention provides relatively short immunogenic peptides, and biologically active variants thereof, associated with leukemia which elicit an immune response. Nucleic acids encoding the immunogenic peptides and antibodies specific for the peptides are also provided. The immunogenic peptides can be included in pharmaceutical compositions, such as cancer vaccines, and used for the treatment of cancer.