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公开(公告)号：US20040005645A1
公开(公告)日：2004-01-08
申请号：US10393992
申请日：2003-03-24
发明人： Samir M. Hanash , David G. Beer , Rork Kuick , Robert Hinderer
IPC分类号： G01N033/574 , C07H021/04 , C07K014/475 , C07K016/30
CPC分类号： G01N33/57488 , G01N33/57407
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.
摘要翻译： 来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。
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公开(公告)号：US20040063120A1
公开(公告)日：2004-04-01
申请号：US10617067
申请日：2003-07-10
发明人： David G. Beer , Sharon Kardia , Thomas J. Giordano , Jeremy Taylor , Samir M. Hanash , Chiang-Ching Huang , David E. Misek , Dafydd Thomas , Rork Kuick
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： G01N33/57423
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with lung cancers. Genes identified as cancer markers find use in the diagnosis and characterization of lung cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与肺癌相关的基因表达谱。 鉴定为癌症标记的基因可用于诊断和鉴定肺癌。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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公开(公告)号：US20030119079A1
公开(公告)日：2003-06-26
申请号：US10244853
申请日：2002-09-16
发明人： Samir M. Hanash , Francois LeNaour , David Misek , Melissa Krause
IPC分类号： G01N033/574
CPC分类号： C07K16/3015 , C07K16/30 , C07K2317/34
摘要： The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.
摘要翻译： 本发明涉及用于癌症治疗和诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与特异性癌症相关的肿瘤抗原和用于检测这些抗原和相关的自身抗体的诊断测定法，以指示特定癌症的存在。 本发明进一步提供利用本发明的肿瘤抗原的癌症免疫疗法。
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公开(公告)号：US20030108553A1
公开(公告)日：2003-06-12
申请号：US10244854
申请日：2002-09-16
发明人： Samir M. Hanash , Laura Beretta , Francois LeNaour
IPC分类号： A61K039/395 , A61K035/78 , G01N033/574
CPC分类号： A61K39/0011 , C07K16/30 , G01N33/574 , G01N33/57438
摘要： The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.
摘要翻译： 本发明涉及用于癌症治疗和诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与特异性癌症相关的肿瘤抗原和用于检测这些抗原和相关的自身抗体的诊断测定法，以指示特定癌症的存在。 本发明进一步提供利用本发明的肿瘤抗原的癌症免疫疗法。
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公开(公告)号：US20040137526A1
公开(公告)日：2004-07-15
申请号：US10686417
申请日：2003-10-15
发明人： Samir M. Hanash , Hong Wang
IPC分类号： G01N033/53 , G01N033/557
CPC分类号： G01N33/6803 , A61K31/00
摘要： The present invention relates to systems, apparatuses and methods for multidimensional protein separation. In particular, the present invention relates to 3-dimension protein separation and characterization systems and methods.
摘要翻译： 本发明涉及用于多维蛋白质分离的系统，装置和方法。 特别地，本发明涉及三维蛋白质分离和表征系统和方法。
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公开(公告)号：US20040010126A1
公开(公告)日：2004-01-15
申请号：US09968930
申请日：2001-10-01
发明人： David M. Lubman , Timothy J. Barder , Daniel B. Wall , Stephen J. Parus , Maureen T. Kachman , Bathsheba E. Chong , Samir M. Hanash , David E. Misek , Robert Hinderer
IPC分类号： C07K001/20
CPC分类号： G01N27/44773 , C07K1/36 , G01N30/02 , G01N30/461 , G01N30/7233 , G01N30/82 , G01N30/8651 , G01N33/6803 , G01N2030/027 , G01N2030/524 , G01N2030/8813 , G01N2030/8831 , B01D15/325
摘要： The present invention relates to multiphase protein separation methods capable of resolving large numbers of cellular proteins. The methods of the present invention provide protein profile maps for imaging and comparing protein expression patterns. The present invention provides alternatives to traditional 2-D gel separation methods for the screening of protein profiles.
摘要翻译： 本发明涉及能够解析大量细胞蛋白质的多相蛋白质分离方法。 本发明的方法提供用于成像和比较蛋白质表达模式的蛋白质谱图。 本发明提供了用于筛选蛋白质谱的传统的2-D凝胶分离方法的替代方案。
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公开(公告)号：US20030077292A1
公开(公告)日：2003-04-24
申请号：US10244855
申请日：2002-09-16
发明人： Samir M. Hanash , Franck Brichory
IPC分类号： A61K039/00 , G01N033/574
CPC分类号： G01N33/57423 , A61K39/0011 , A61K2039/55522 , C07K14/47 , C07K16/3023 , G01N33/564
摘要： The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.
摘要翻译： 本发明涉及用于癌症治疗和诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与特异性癌症相关的肿瘤抗原和用于检测这些抗原和相关的自身抗体的诊断测定法，以指示特定癌症的存在。 本发明进一步提供利用本发明的肿瘤抗原的癌症免疫疗法。
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