公开(公告)号：US10912837B2

公开(公告)日：2021-02-09

申请号：US15549787

申请日：2016-02-09

Applicant: MOSAIC BIOSCIENCES, INC.

Inventor： Alexei V. Kazantsev ,  Peter D. Mariner ,  Martin Stanton

IPC: C07K1/13 ,  A61K47/60 ,  C08G75/12 ,  C08G75/045 ,  C08J3/24 ,  C08G81/00 ,  C08H1/00 ,  C07K1/107 ,  C12N9/36 ,  C08B37/00 ,  C07K14/78 ,  C08J3/075 ,  C08L101/16 ,  A61K9/06 ,  A61K38/08 ,  A61K38/10 ,  A61K38/39 ,  C08G65/334

Abstract: Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.

公开(公告)号：US10821078B2

公开(公告)日：2020-11-03

申请号：US15637333

申请日：2017-06-29

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sijia Yi ,  Sean D. Allen

IPC: A61K9/127 ,  A61K47/34 ,  C08G65/334 ,  A61K49/00 ,  C08G75/14

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

公开(公告)号：US20200276320A1

公开(公告)日：2020-09-03

申请号：US16878401

申请日：2020-05-19

Applicant: Nektar Therapeutics

Inventor： Michael D. Bentley ,  Sean M. Culbertson ,  Samuel P. McManus

IPC: A61K47/60 ,  C08G61/02 ,  C07C235/68 ,  C07D207/46 ,  C07K14/575 ,  C08G65/48 ,  C08G65/338 ,  A61K38/26 ,  A61K38/28 ,  C08G65/333 ,  C08G65/334 ,  C08K5/13

Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

公开(公告)号：US20200224258A1

公开(公告)日：2020-07-16

申请号：US16708050

申请日：2019-12-09

Applicant: Pacific Biosciences of California, Inc.

Inventor： Gene Shen ,  Natasha Popovich ,  Erik Miller ,  Satwik Kamtekar ,  Keith Bjornson ,  Jeremiah Hanes ,  Stephen Yue ,  Lubomir Sebo ,  Zhong Wang

IPC: C12Q1/6844 ,  C07D495/04 ,  C08G65/334 ,  C07F7/18 ,  C07D403/14 ,  C07D401/14 ,  C12N11/06 ,  C07K14/36

Abstract: Multi-biotinylated reactants are provided which can be used in divalent complexes for various applications such as colocalization, labeling, immobilization, and purification. Methods for constructing, purifying, and using the bis-biotinylated reactants are also provided. In certain embodiments, two bis-biotinylated reactants are bound to a single streptavidin tetramer to provide a complex having a 1:1 stoichiometry with respect to the bis-biotinylated reactants.

公开(公告)号：US10695435B2

公开(公告)日：2020-06-30

申请号：US16160770

申请日：2018-10-15

Applicant: Nektar Therapeutics

Inventor： Michael D. Bentley ,  Sean M. Culbertson ,  Samuel P. McManus

IPC: A61K9/00 ,  A61K47/60 ,  C08G61/02 ,  C07C235/68 ,  C07D207/46 ,  C07K14/575 ,  C08G65/48 ,  C08G65/338 ,  A61K38/26 ,  A61K38/28 ,  C08G65/333 ,  C08G65/334 ,  C08K5/13 ,  A61K31/765

Abstract: The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. The conjugates as well as the polymeric reagents used to form the conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

公开(公告)号：US10570253B2

公开(公告)日：2020-02-25

申请号：US16067015

申请日：2016-11-07

Applicant: SOBUTE NEW MATERIALS CO., LTD. ,  BOTE BUILDING MATERIALS (TIANJIN) CO., LTD.

Inventor： Qianping Ran ,  Jiaping Liu ,  Tao Wang ,  Jianfeng Ma ,  Shuai Qi ,  Shimin Fan ,  Yong Yang

IPC: C08G65/335 ,  C08G65/331 ,  C08G65/332 ,  C04B24/24 ,  C04B28/02 ,  C08G65/334 ,  C04B24/22 ,  C04B103/40

Abstract: The present invention provides a method for preparing a polymer and a use of the polymer. The resulting polymer is used as a dispersant for an aqueous dispersion of a hydraulic binder and/or a latent hydraulic binder, such that water-reducing rate is improved, and suitable control of air content can be achieved, thereby improving the strength of concrete. The method for preparing a polymer includes polycondensation of a polyether macromonomer A of a specific structure, a monomer B and an aldehyde C to obtain the polymer. The monomer B is phenylsulfonic acid, p-/o-aminophenylsulfonic acid, p-/o-hydroxylbenzoic acid, p-/o-aminobenzoic acid, p-/o-hydroxylphenylsulfonic acid, or a phosphoric acid group or phosphorous acid group-containing monomer of a specific structure. A molar ratio of the polyether macromonomer A and the monomer B is 1:(0.5 to 12).

公开(公告)号：US20200017635A1

公开(公告)日：2020-01-16

申请号：US16303769

申请日：2017-05-26

Applicant: SPHERE FLUIDICS LIMITED

Inventor： Xin LI ,  Olive A Smith ,  Alexandra Clay ,  Frank F Craig

IPC: C08G65/332 ,  C08G65/00 ,  C08G65/333 ,  C08G65/334 ,  C12Q1/6806 ,  B01F17/00

Abstract: The present invention provides a surfactant having a formula selected from the group consisting of: B—((X)x—(CH2)a-Mn(VI), (A-(CH2)—(X)x—B—(X)x—(CH2)a-A)n (IV), (A-(CH2)a—(X)x—B)n (V), and (B)n—(X)x—(CH2)a—A (VII), wherein A is a perfluoropolyether; a is a positive integer; X is either a covalent bond or a linking group; x is a positive integer; B is a polyalkylene oxide unit; n is a positive integer greater than 1 and, in compounds comprising more than one A, B, X, a and x, each may be the same or different. The present invention also relates to methods of making such surfactants, uses of such surfactants and emulsions comprising such surfactants.

公开(公告)号：US20190381031A1

公开(公告)日：2019-12-19

申请号：US16429822

申请日：2019-06-03

Applicant: Northwestern University ,  The Wistar Institute of Anatomy and Biology

Inventor： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC: A61K31/4745 ,  C08G65/333 ,  C12N9/02 ,  C08G65/332 ,  C08G65/334 ,  A61K47/60

Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

公开(公告)号：US10392474B2

公开(公告)日：2019-08-27

申请号：US15545272

申请日：2016-01-20

Applicant: FREIE UNIVERSITAET BERLIN ,  THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： Donald Brooks ,  Jayachandran Kizhakkedathu ,  Rajesh Shenoi ,  Marie Weinhart ,  Benjamin Lai ,  Rainer Haag ,  Dominic Groeger

IPC: C08G65/32 ,  C08G65/334 ,  A61K31/255 ,  A61K38/36

Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

公开(公告)号：US10376591B2

公开(公告)日：2019-08-13

申请号：US15703110

申请日：2017-09-13

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Song Li ,  Yixian Huang ,  Xiaolan Zhang ,  Xiang Gao

IPC: A61K47/60 ,  A61K31/337 ,  A61K31/235 ,  A61K31/704 ,  A61K9/00 ,  A61K9/107 ,  C08G65/331 ,  C08G65/333 ,  C08G65/334

Abstract: A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.