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388 条记录 (耗时 0.037 秒)

    Organic ionic phenylpyrimidine compounds and displays formed thereof
    12.
    发明授权
    Organic ionic phenylpyrimidine compounds and displays formed thereof 有权
    有机离子苯基嘧啶化合物及其形成的显示器

    公开(公告)号：US08512820B2

    公开(公告)日：2013-08-20

    申请号：US13160175

    申请日：2011-06-14

    申请人： Yongqiang Zhang ,  Su Yang

    发明人： Yongqiang Zhang ,  Su Yang

    IPC分类号： C09K19/34 ,  C07D239/02 ,  C07D239/10 ,  C07D239/24 ,  C07D239/34 ,  C07D239/38 ,  C07F9/54

    CPC分类号： C09K19/0225 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C09K19/3469 ,  C09K19/404 ,  C09K19/582 ,  Y10T428/10

    摘要： Ionic mesogenic compounds of formula (I) can be used to form liquid crystal displays, such as ferroelectric liquid crystal displays, having enhanced anti-image sticking properties. The mesogenic compounds may contain a cationic group such as an ammonium or phosphonium group bonded to an alkyl chain that is terminally bonded to a para-substituted pyrimidyl benzene moiety. The counterion can be an organic or inorganic anion. The compounds can be used either as dopants in art ferroelectric liquid crystal compositions to reduce image sticking, or can be used as the primary or predominant component of a liquid crystal display system. Additional compounds, devices, and methods are disclosed.

    摘要翻译： 式（I）的离子型介晶化合物可用于形成具有增强的抗图像粘附性能的液晶显示器，例如铁电液晶显示器。 介晶化合物可以含有阳离子基团，例如与末端键合到对位取代的嘧啶基苯部分的烷基链键合的铵或鏻基团。 抗衡离子可以是有机或无机阴离子。 这些化合物可以用作艺术铁电液晶组合物中的掺杂剂，以减少图像残留，或者可以用作液晶显示系统的主要或主要成分。 公开了其它化合物，装置和方法。

    CYCLIC N,N'-DIARYLTHIOUREAS AND N,N'-DIARYLUREAS - ANDROGEN RECEPTOR ANTAGONISTS, ANTICANCER AGENT, METHOD FOR PREPARATION AND USE THEREOF
    15.
    发明申请
    CYCLIC N,N'-DIARYLTHIOUREAS AND N,N'-DIARYLUREAS - ANDROGEN RECEPTOR ANTAGONISTS, ANTICANCER AGENT, METHOD FOR PREPARATION AND USE THEREOF 有权
    循环N，N-二异丙基呋喃和N，N-二元醇 - 雄激素受体拮抗剂，抗原剂，其制备和使用方法

    公开(公告)号：US20130116269A1

    公开(公告)日：2013-05-09

    申请号：US13811282

    申请日：2011-07-01

    申请人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

    发明人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

    IPC分类号： C07D233/86 ,  C07D471/10 ,  C07D249/12 ,  C07D239/10

    CPC分类号： C07D233/86 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/2095 ,  A61K9/4858 ,  C07D233/72 ,  C07D239/10 ,  C07D239/22 ,  C07D249/12 ,  C07D471/10 ,  C07D491/107

    摘要： The present invention relates to novel cyclic N,N′-diarylureas and N,N′-diarylthioureas—androgen receptor antagonists, anti-cancer agent, pharmaceutical composition, medicament, and method for treatment of cancerous diseases, among them prostate cancer.Cyclic N,N′-diarylthioureas or N,N′-diarylureas of the general formula 1, their optical (R)- and (S)-isomers and pharmaceutically acceptable salts thereof exhibiting properties of androgen receptor antagonists have been proposed, wherein: X represents oxygen or sulfur; m=0 or 1; R1 represents C1-C3alkyl; R2 and R3 represent hydrogen; or R2 and R3 together with C-atom they are attached to form C═O group; R4 and R5 represent hydrogen; or R4 represents hydrogen, R5 represents methyl; or R4 represents methyl, R5 represents CH2R6 group in which R6 represents C1-C3 alkoxycarbonyl, carboxyl, hydroxyl group optionally substituted with methyl or benzyl; or R4 and R5 together with C-atom they are attached to form 5- or 6-membered heterocycle comprising at least one oxygen atom or nitrogen atom optionally substituted with methyl; or R4 and R5 together with C-atom they are attached to form NH group.

    摘要翻译： 本发明涉及新型环状N，N'-二芳基脲和N，N'-二芳基硫脲 - 雄激素受体拮抗剂，抗癌剂，药物组合物，药物及其治疗癌症的方法，其中前列腺癌。 已经提出了通式1的环状N，N'-二芳基硫脲或N，N'-二芳基脲，其表现出雄激素受体拮抗剂性质的光学（R） - 和（S） - 异构体及其药学上可接受的盐，其中：X 代表氧或硫; m = 0或1; R1代表C1-C3烷基; R2和R3表示氢; 或R 2和R 3与它们连接的C原子一起形成C = O基团; R4和R5代表氢; 或R 4表示氢，R 5表示甲基; 或R 4表示甲基，R 5表示CH 2 R 6基，其中R 6表示C 1 -C 3烷氧基羰基，羧基，任选被甲基或苄基取代的羟基; 或R 4和R 5与它们连接的C原子一起形成包含至少一个氧原子或任选被甲基取代的氮原子的5-或6-元杂环; 或R 4和R 5与它们连接的C原子一起形成NH基团。

    Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols
    16.
    发明授权
    Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols 有权
    使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲硫氨酸氧杂多糖检测跨膜电位

    公开(公告)号：US08329390B2

    公开(公告)日：2012-12-11

    申请号：US11212203

    申请日：2005-08-25

    申请人： Zhenjun Diwu ,  Jianjun He ,  Yi Tang

    发明人： Zhenjun Diwu ,  Jianjun He ,  Yi Tang

    IPC分类号： C12Q1/00 ,  C07D403/00 ,  C07D239/10 ,  C07D239/66

    CPC分类号： C07D239/66 ,  G01N33/52

    摘要： The present invention relates generally to the detection and measurement of transmembrane potentials using an N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol (shown below). In particular, the present invention is directed to compositions and optical methods for determining transmembrane potentials across the plasma membrane of biological cells using a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols. The method comprises a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol anion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes. wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl and heteroalkyl; n is an integer from 1 to 3; Z is Na, K, ammonium or other biologically acceptable salt.

    摘要翻译： 本发明一般涉及使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多酚（如下所示）检测和测量跨膜电位。 特别地，本发明涉及使用稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多糖测定生物细胞质膜跨膜电位的组合物和光学方法。 该方法包括一种稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂氮杂阴离子，其能够响应膜的电位变化而从膜的第一面再分配到膜的第二面。 在一个方面，该方法用于鉴定调节生物膜中膜电位的化合物。 其中R1，R2和R3独立地选自氢，烷基，卤代烷基和杂烷基; n为1〜3的整数， Z是Na，K，铵或其他生物可接受的盐。