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    Method for antimicrobial susceptibility testing of microorganisms
    13.
    发明授权
    Method for antimicrobial susceptibility testing of microorganisms 失效
    微生物抗微生物药敏试验方法

    公开(公告)号：US07262021B1

    公开(公告)日：2007-08-28

    申请号：US11028155

    申请日：2005-01-03

    Applicant: Read Taintor

    Inventor： Read Taintor

    IPC: C12Q1/00 ,  C12Q1/04 ,  C12Q1/08 ,  C12Q1/20 ,  C12N1/24 ,  C12N1/00 ,  C12N1/20

    CPC classification number: C12Q1/04

    Abstract: Media, kits, and methods are disclosed for use in processes requiring microbial culture. More specifically, the invention provides carrageenan-stabilized agar-based microbial culture media for kits and methods. The media and kits of the invention possess increased shelf-life stability over currently available agar-based media. Further, the media, kits, and methods are useful in the manual determination of identification and antimicrobial susceptibility testing of the pathogen/s contained in a specimen or sample in periods of about 12 to 24 hours. The stabilized culture media of the invention are useful in a broad variety of applications.

    Abstract translation: 公开了用于需要微生物培养的过程的介质，试剂盒和方法。 更具体地，本发明提供了用于成套工具和方法的角叉菜胶稳定化的基于琼脂的微生物培养基。 本发明的培养基和试剂盒比目前可用的基于琼脂的培养基具有更高的保质期稳定性。 此外，介质，试剂盒和方法可用于在约12至24小时期间手动测定样品或样品中所含病原体的鉴定和抗微生物敏感性测试。 本发明的稳定化培养基可用于各种各样的应用。

    Reflective disc assay devices, systems and methods
    15.
    发明授权
    Reflective disc assay devices, systems and methods 失效
    反射盘测定装置，系统和方法

    公开(公告)号：US06900028B2

    公开(公告)日：2005-05-31

    申请号：US10268654

    申请日：2002-10-10

    Applicant: Peter D. Wickert ,  Michael G. Williams ,  Christine A. Binsfeld

    Inventor： Peter D. Wickert ,  Michael G. Williams ,  Christine A. Binsfeld

    IPC: C12M1/20 ,  C12M1/34 ,  C12Q1/08 ,  C12Q1/02

    CPC classification number: C12M41/36 ,  C12M25/02 ,  C12Q1/04

    Abstract: Disc assay devices and methods for the detection and enumeration of microorganisms are disclosed. The devices and methods include a plurality of discs attached to a substrate and a reflector on one surface of each of the discs to reflect electromagnetic energy of selected wavelengths after the energy has passed through the disc. The reflector may be useful to improve the accuracy of detection and/or enumeration of target microorganisms on the assay devices. A system for detecting and/or enumerating target microorganisms on disc assay devices is also provided.

    Abstract translation: 公开了用于微生物检测和计数的盘测定装置和方法。 装置和方法包括在每个盘的一个表面上附接到基板的多个盘和反射器，以在能量已经通过盘之后反射所选波长的电磁能。 反射器可用于提高测定装置上靶微生物的检测和/或计数的准确性。 还提供了用于在盘测定装置上检测和/或计数目标微生物的系统。

    Method utilizing convex geometry for laser capture microdissection
    17.
    发明授权
    Method utilizing convex geometry for laser capture microdissection 失效
    用于激光捕获显微切割的凸几何的方法

    公开(公告)号：US6100051A

    公开(公告)日：2000-08-08

    申请号：US883821

    申请日：1997-06-27

    Applicant: Seth R. Goldstein ,  Robert F. Bonner ,  Paul D. Smith ,  John Peterson ,  Thomas Pohida

    Inventor： Seth R. Goldstein ,  Robert F. Bonner ,  Paul D. Smith ,  John Peterson ,  Thomas Pohida

    IPC: G01N1/28 ,  G02B21/34 ,  C12Q1/08

    CPC classification number: G02B21/34 ,  G01N1/2813 ,  G01N2001/2833 ,  G01N2001/284 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    Abstract: A process of microdissection where a tissue sample is conventionally visualized in a microscope. A selectively activatable convex surface is provided, preferably on the periphery at the distal end of a rod. This selectively activatable convex surface when locally activated, typically with a laser through an optic light path in the microscope, provides the activated region with adhesive properties. The tissue sample has at least one portion, which is to be extracted is identified. This identified portion is contacted with a portion of the selectively activatable convex surface on the periphery of the rod. When the convex surface is locally activated, typically by exposure to laser light in the footprint of the desired portion, an adhesive transfer surface on the selectively activatable convex surface is activated which adheres to the desired cells in the footprint of the desired portion. Thereafter, the adhesive transfer surface is separated from the remainder of the tissue sample while maintaining adhesion with the portion of the sample. Thus the desired portion of the tissue sample is extracted. The disclosed selectively activatable convex surface is preferably utilized to collect desired tissue samples at more than one location on the same slide or from different slides. A rod having a convex surface with the selectively activatable material is set forth as a staple for use with the apparatus and process. Preferred shapes for the convex surface are disclosed as well as a method for coating rods.

    Abstract translation: 显微切割的过程，其中组织样品通常在显微镜中可视化。 优选地，在棒的远端的周边上设置有选择性激活的凸面。 当局部激活时，这种选择性激活的凸表面通常在显微镜中通过光学光路通过激光提供具有粘合性质的激活区域。 组织样本具有至少一部分要被提取的部分。 该识别部分与杆的周边上的可选择性激活的凸面的一部分接触。 当凸表面被局部激活时，通常通过暴露在所需部分的覆盖区内的激光，激活可选择性激活的凸表面上的粘合剂转移表面，该粘合剂转移表面在期望部分的覆盖区中粘附到期望的电池。 此后，粘合剂转移表面与组织样品的其余部分分离，同时保持与样品部分的粘附。 因此，提取组织样本的期望部分。 所公开的可选择激活的凸表面优选用于在相同载片上或不同载玻片上的多于一个位置收集所需的组织样本。 具有具有可选择性活化材料的凸起表面的杆被设置为与装置和工艺一起使用的订书钉。 公开了用于凸表面的优选形状以及用于涂覆棒的方法。

    Assay for determination of neuronal activity in brain tissue
    18.
    发明授权
    Assay for determination of neuronal activity in brain tissue 失效
    测定脑组织中的神经元活性

    公开(公告)号：US5998139A

    公开(公告)日：1999-12-07

    申请号：US838769

    申请日：1997-04-10

    Applicant: Gary Lynch ,  Richard Granger ,  Christine M. Gall ,  Linda C. Palmer

    Inventor： Gary Lynch ,  Richard Granger ,  Christine M. Gall ,  Linda C. Palmer

    IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/08

    CPC classification number: C12Q1/6809 ,  C12Q1/6841 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: The activation of neurons in specific areas of a mammalian brain are determined by measurement of levels of mRNA following administration of an agent that potentially affects neuronal activity. Differential levels of mRNA caused by an agent can be measured, as can the specific distribution of the alteration of neuronal activity. Many mental disorders are associated with the abnormal function of a particular area of the brain. The present invention allows the determination of which area of the brain, if any, is affected by an administered agent. Accordingly, the invention provides a valuable tool for assaying compounds as potential therapeutic agents.

    Abstract translation: 在哺乳动物脑的特定区域中的神经元的激活通过在施用潜在影响神经元活性的试剂后测量mRNA的水平来确定。 可以测量由药剂引起的mRNA的差异水平，以及神经元活性改变的具体分布。 许多精神障碍与脑的特定区域的异常功能相关。 本发明允许确定脑的哪个区域（如果有的话）受给药剂的影响。 因此，本发明提供了用于测定化合物作为潜在治疗剂的有价值的工具。

    Apparatus for testing paraffinophilic microorganisms for antimicrobial sensitivity
    19.
    发明授权
    Apparatus for testing paraffinophilic microorganisms for antimicrobial sensitivity 失效
    用于测试抗菌敏感性的石蜡微生物的装置

    公开(公告)号：US5854014A

    公开(公告)日：1998-12-29

    申请号：US897813

    申请日：1997-07-21

    Applicant: Robert-A. Ollar

    Inventor： Robert-A. Ollar

    IPC: C12M1/00 ,  C12M1/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/08 ,  C12Q1/14 ,  C12Q1/18

    CPC classification number: C12M23/08 ,  C12Q1/18 ,  G01N2333/35

    Abstract: An apparatus for determining the antimicrobial agent sensitivity of a paraffinophilic microorganism from a specimen obtained from a patient. The apparatus includes a receptacle containing an aqueous solution, an amount of antimicrobial agent to be tested and the specimen. The apparatus further consists of a paraffin coated slide placed into the receptacle.

    Abstract translation: 用于从患者获得的样本中测定嗜热微生物的抗微生物剂敏感性的装置。 该装置包括容纳水溶液的容器，一定量的待测试的抗微生物剂和样品。 该设备还包括放置在容器中的石蜡涂布的滑块。

    Detection of prokaryotic organism by DNA hybridization
    20.
    发明授权
    Detection of prokaryotic organism by DNA hybridization 失效
    通过DNA杂交检测原核生物

    公开(公告)号：US5851767A

    公开(公告)日：1998-12-22

    申请号：US469600

    申请日：1995-06-06

    Applicant: Eric J. Stanbridge ,  Ulf Gobel

    Inventor： Eric J. Stanbridge ,  Ulf Gobel

    IPC: C07H21/04 ,  C12N15/11 ,  C12Q1/08 ,  C12Q1/68

    CPC classification number: C12Q1/689

    Abstract: Biological probes useful for detecting mycoplasmas or prokaryotes in general, or specific mycoplasma and eubacterial species are derived from the ribosomal RNA gene by selecting particular nucleotide sequences common to the class of organisms being detected.

    Abstract translation: 可用于检测一般支原体或原核生物或特异性支原体和真细菌物种的生物探针通过选择检测到的生物体类别中常见的特定核苷酸序列衍生自核糖体RNA基因。

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