公开(公告)号：US20180056253A1

公开(公告)日：2018-03-01

申请号：US15561503

申请日：2016-03-23

Applicant: South Dakota Board of Regents

Inventor： Ilchgerel Dash ,  Robb M. Winter

IPC: B01F7/00 ,  C08J5/00 ,  C08J3/20 ,  B01F15/06

Abstract: An improved a device and method for dispersion and simultaneous orientation of nanoparticles within a matrix is provided. A mixer having a shaft and a stator is provided. The shaft may have a rupture region and erosion region. Further, an orienter having an angled stationary plate and a moving plate are provided. The nanoparticles and the matrix are fed into the mixer. A rotational force is applied to the shaft to produce shearing forces. The shearing forces disperse and exfoliate the nanoparticles within the matrix. The dispersed mixture is outputted onto the moving plate. The moving plate is forced across the angled stationary plate to produce fully developed laminar shear flow. The fully developed laminar shear flow or the two-dimensional extensional drag flow orients the dispersed nanoparticles-matrix mixture.

公开(公告)号：US09623103B2

公开(公告)日：2017-04-18

申请号：US14413385

申请日：2013-07-18

Applicant: SOUTH DAKOTA BOARD OF REGENTS ,  CAMBRIDGE ENTERPRISE LIMITED ,  ACADEMISCH ZIEKENHUIS LEIDEN ,  UNIVERSITY COLLEGE CORK

Inventor： Ying Fang ,  Eric John Snijder ,  Andrew E. Firth ,  John F. Atkins ,  Emma Elisabeth Treffers ,  Ali Tas ,  Yanhua Li

IPC: A61K39/12 ,  C12N7/00 ,  C07K16/10 ,  C07K14/005 ,  G06F19/18 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/10011 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10062 ,  G06F19/18

Abstract: The invention provides the discovery and characterization of a novel arterivirus protein (nsp2TF), whose expression is dependent on −2 ribosomal frameshifting at a site located in the nsp2 coding region. The coding region for the unique TF domain of nsp2TF overlaps the part of ORF1a that encodes the transmembrane region of nsp2 in arteriviruses, including PRRSV, LDV and SHFV. Mutations affecting the expression of nsp2TF impair PRRSV replication and result in a smaller plaque phenotype. Provided herein are arteriviruses that display reduced translation of nsp2TF and/or altered translation of one or more downstream products, arteriviruses in which nsp2TF function is reduced and/or absent, and vaccines comprising said arteriviruses. Also provided herein are diagnostic methods, methods for identifying compounds that inhibit −2 frameshifting, and gene expression tools for eukaryotic systems utilizing −2 frameshifting.

公开(公告)号：US09396853B2

公开(公告)日：2016-07-19

申请号：US14143453

申请日：2013-12-30

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOUTH DAKOTA BOARD OF REGENTS

Inventor： Haiping Hong ,  G. P. “Bud” Peterson

IPC: H01F1/44

CPC classification number: H01F1/445 ,  B82Y30/00 ,  C08K3/04 ,  C08K3/045 ,  C08K3/046 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2201/01 ,  C08K2201/011 ,  H01F1/44 ,  Y10S977/742

Abstract: The present invention is a nanoparticle mixture or suspension or nanofluid comprising nonmagnetically sensitive nanoparticles, magnetically sensitive nanoparticles, and surfactant(s). The present invention also relates to methods of preparing and using the same.

Abstract translation: 本发明是包含非磁性敏感纳米颗粒，磁敏纳米颗粒和表面活性剂的纳米颗粒混合物或悬浮液或纳米流体。 本发明还涉及其制备和使用方法。

公开(公告)号：US09312046B2

公开(公告)日：2016-04-12

申请号：US14577552

申请日：2014-12-19

Applicant: SOUTH DAKOTA BOARD OF REGENTS ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： Haiping Hong ,  G.P. (Bud) Peterson ,  David R. Salem

IPC: H01B1/24 ,  H01F1/01 ,  C08K3/04 ,  H01B1/04 ,  C08K3/22

CPC classification number: H01B1/24 ,  C08K3/04 ,  C08K3/041 ,  C08K3/042 ,  C08K3/045 ,  C08K3/046 ,  C08K3/08 ,  C08K3/22 ,  C08K2003/2265 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2003/2289 ,  C08K2003/2293 ,  C08K2201/011 ,  H01B1/04 ,  H01F1/01 ,  H01F1/447 ,  C08L63/00

Abstract: Magnetically aligned carbon nanoparticle composites have enhanced electrical properties. The composites comprise carbon nanoparticles, a host material, magnetically sensitive nanoparticles and a surfactant. In addition to enhanced electrical properties, the composites can have enhanced mechanical and thermal properties.

Abstract translation: 磁性排列的碳纳米颗粒复合材料具有增强的电性能。 复合材料包括碳纳米颗粒，主体材料，磁敏纳米颗粒和表面活性剂。 除了增强的电学性能，复合材料可以具有增强的机械和热性能。

公开(公告)号：US20150228388A1

公开(公告)日：2015-08-13

申请号：US14178948

申请日：2014-02-12

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOUTH DAKOTA BOARD OF REGENTS

Inventor： Haiping Hong ,  G.P. (Bud) Peterson ,  David R. Salem

IPC: H01F1/44

CPC classification number: H01F1/445 ,  B82Y30/00 ,  C08K3/04 ,  C08K3/045 ,  C08K3/046 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2201/01 ,  C08K2201/011 ,  H01F1/44 ,  Y10S977/742

Abstract: The present invention relates to magnetically aligned carbon nanoparticle composites and methods of preparing the same. The composites comprise carbon nanoparticles, host material, magnetically sensitive nanoparticles and surfactant. The composites may have enhanced mechanical, thermal, and/or electrical properties.

Abstract translation: 本发明涉及磁性排列的碳纳米颗粒复合材料及其制备方法。 复合材料包括碳纳米颗粒，主体材料，磁敏纳米颗粒和表面活性剂。 复合材料可能具有增强的机械，热和/或电性能。

公开(公告)号：US20150190555A1

公开(公告)日：2015-07-09

申请号：US14418635

申请日：2013-07-17

Applicant: South Dakota Board of Regents

Inventor： Gopinath Mani

IPC: A61L31/16 ,  A61F2/82 ,  A61L31/12 ,  A61F2/07

CPC classification number: A61L31/16 ,  A61F2/07 ,  A61F2/82 ,  A61F2/86 ,  A61F2/915 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/12 ,  A61L2300/114 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2400/18 ,  A61L2420/00

Abstract: Implantable medical devices may directionally elute a first therapeutic agent that promotes the growth of endothelial cells and a second therapeutic agent that inhibits the growth of smooth muscle cells. In some embodiments, implantable medical devices may elute a first therapeutic agent such as an anti-proliferative drug from an abluminal side of the implantable medical device and a second therapeutic agent such as an endothelialization agent from a luminal side of the implantable medical device.

Abstract translation: 可植入医疗装置可以定向洗脱促进内皮细胞生长的第一治疗剂和抑制平滑肌细胞生长的第二治疗剂。 在一些实施方案中，可植入医疗装置可以从植入式医疗装置的腔内侧洗脱第一治疗剂，例如抗增殖药物，以及来自可植入医疗装置的腔侧的第二治疗剂，例如内皮化剂。

公开(公告)号：US20140271530A1

公开(公告)日：2014-09-18

申请号：US14213063

申请日：2014-03-14

Applicant: South Dakota Board of Regents

Inventor： Hemachand Tummala ,  Sunny Kumar

IPC: A61K47/48 ,  A61K31/12

CPC classification number: A61K47/48176 ,  A61K31/12 ,  A61K47/58

Abstract: Methods and materials relating to a medicament preparation comprising a curcuminoid component and a eudragit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.

Abstract translation: 涉及一种药物制剂的方法和材料，所述药物制剂包含姜黄素组分和作为姜黄素 - 鬼草苷复合物提供的eudragit组分，其增强姜黄素组分的生物利用度，并且可用于治疗各种疾病，包括癌症，神经变性，炎症和免疫缺陷 。 在一些方面，姜黄素组分包含姜黄素以制备姜黄素 - udragit复合物和包含姜黄素 - udragit复合物的药物。