公开(公告)号：US07111649B2

公开(公告)日：2006-09-26

申请号：US11103803

申请日：2005-04-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送，其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合，以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出，并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。

公开(公告)号：US07096896B2

公开(公告)日：2006-08-29

申请号：US11070440

申请日：2005-03-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A robotic arm of the apparatus is drivingly mounted adjacent to the container support and movable relative thereto. A manifold is drivingly mounted on the robotic arm and includes (1) a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container; (2) a laser optic assembly for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper; and (3) a temperature sensor for sensing the temperate of a needle penetrated region of the stopper to determine whether a needle hole therein is sealed. The manifold is movable laterally relative to the container on the container support to position the manifold relative to a needle penetrable region of the stopper of the container.

Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从其中取出针时将塞子中的针孔热封闭。 装置的机器臂相对于容器支架驱动地安装并相对于其移动。 歧管被驱动地安装在机器臂上，并且包括（1）用于穿透可再密封止动件的针并将物质通过针引入容器中; （2）激光光学组件，用于加热塞子的针穿透区域，并进而密封塞子中的针孔; 以及（3）温度传感器，用于检测塞子的针穿透区域的温度，以确定其中的针孔是否被密封。 歧管相对于容器支架上的容器横向移动，以使歧管相对于容器的塞子的针可穿透区域定位。

公开(公告)号：US07092175B2

公开(公告)日：2006-08-15

申请号：US10990660

申请日：2004-11-16

Applicant: Daniel Py

Inventor： Daniel Py

IPC: G02B7/02

CPC classification number: A61F9/0061 ,  A45C11/005

Abstract: A contact lens transfer device for transferring a contact lens from a storage container to a contact lens applicator has a body and a contact lens holder movably mounted on the body. The contact lens holder defines a contact lens support surface, a fluid-flow aperture extending through the contact lens support surface, and a chamber coupled in fluid communication with the fluid-flow aperture. A contact lens is removably receivable on the lens support surface, and the fluid-flow aperture is coupled in fluid communication with an interface between the contact lens and lens support surface for introducing fluid from the chamber, through the fluid-flow aperture and into the interface to release the lens from the lens support surface.

Abstract translation: 用于将隐形眼镜从存储容器转移到隐形眼镜施加器的隐形眼镜转移装置具有可移动地安装在身体上的身体和隐形眼镜保持器。 隐形眼镜保持器限定隐形眼镜支撑表面，延伸穿过隐形眼镜支撑表面的流体流动孔，以及与流体流动孔流体连通的腔室。 隐形眼镜可移除地容纳在透镜支撑表面上，并且流体流动孔与隐形眼镜和透镜支撑表面之间的界面流体连通地联接，用于将来自腔室的流体引导通过流体流动孔并进入 界面以从透镜支撑表面释放透镜。

公开(公告)号：US20060131338A1

公开(公告)日：2006-06-22

申请号：US11351716

申请日：2006-02-10

Applicant: Daniel Py ,  Joseph Ting

Inventor： Daniel Py ,  Joseph Ting

IPC: B67D5/06

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

Abstract translation: 用于分配流体的分配器包括具有包含流体的主流体室的刚性小瓶和与主流体室流体连通并被构造成从主流体室分配预定量的流体的泵组件。 提供柔性囊，其位于主流体室内并且构造成膨胀以填充由泵组件分配流体期间在主流体室内产生的空位。 弹性气囊趋于朝向刚性小瓶向外强制，并且与气囊的内部相比增加了主流体室内的压力，从而防止空气或蒸气进入气囊或以其它方式进入主体 流体室。

公开(公告)号：USD518144S1

公开(公告)日：2006-03-28

申请号：US29225228

申请日：2005-03-14

Applicant: Daniel Py ,  Norbert M. Assion ,  Stephanie Ferreira

Designer： Daniel Py ,  Norbert M. Assion ,  Stephanie Ferreira

公开(公告)号：US07000806B2

公开(公告)日：2006-02-21

申请号：US10890465

申请日：2004-07-12

Applicant: Daniel Py ,  Joseph M. Ting

Inventor： Daniel Py ,  Joseph M. Ting

IPC: B67D5/042

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

Abstract translation: 用于分配流体的分配器包括具有包含流体的主流体室的刚性小瓶和与主流体室流体连通并被构造成从主流体室分配预定量的流体的泵组件。 提供柔性囊，其位于主流体室内并且构造成膨胀以填充由泵组件分配流体期间在主流体室内产生的空位。 弹性气囊趋于朝向刚性小瓶向外强制，并且与气囊的内部相比增加了主流体室内的压力，从而防止空气或蒸气进入气囊或以其它方式进入主体 流体室。

公开(公告)号：US20060017297A1

公开(公告)日：2006-01-26

申请号：US11137866

申请日：2005-05-23

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00

CPC classification number: A61F9/0061

Abstract: An apparatus and method are provided for applying and removing contact lenses. The apparatus has an actuator and two tissue-engaging surfaces drivingly coupled to the actuator for engaging tissue adjacent to the eye in connection with actuating the actuator and to facilitate retaining the eye open during removal of the contact lens therefrom. A support surface supports the apparatus adjacent to the eye, and a lens removing member is drivingly coupled to the actuator for movement between an extended position and a retracted position for removing the contact lens from the eye. The actuator actuates the tissue-engaging surface to facilitate retaining the eye open during removal of the contact lens therefrom, and substantially simultaneously actuates the lens removing member to remove the contact lens from the open eye.

Abstract translation: 提供了一种用于施加和去除隐形眼镜的装置和方法。 该装置具有致动器和驱动地连接到致动器的两个组织接合表面，用于与邻近眼睛的组织接合以致动致动器，并且有助于在从其移除隐形眼镜期间保持眼睛张开。 支撑表面支撑邻近眼睛的装置，并且透镜去除构件驱动地联接到致动器，用于在延伸位置和缩回位置之间移动，以从眼睛移除隐形眼镜。 致动器致动组织接合表面以有助于在从其中移除隐形眼镜期间保持眼睛打开，并且基本上同时致动透镜去除构件以从露出眼睛去除隐形眼镜。

公开(公告)号：USD512646S1

公开(公告)日：2005-12-13

申请号：US29198293

申请日：2004-01-27

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Giovanni Rodriguez ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Giovanni Rodriguez ,  Gladys Valencia

公开(公告)号：US06971999B2

公开(公告)日：2005-12-06

申请号：US10294926

申请日：2002-11-14

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: A61M20060101 ,  A61M5/00 ,  A61M5/24 ,  A61M5/315 ,  A61M5/32 ,  A61M5/42 ,  A61M5/46

CPC classification number: A61M5/425 ,  A61M5/24 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/3287 ,  A61M5/46

Abstract: The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.

Abstract translation: 受试者皮内递送装置提供穿透至固定深度，而不需要用户的专门知识。 该装置由嵌套在内壳和外壳内的注射器组成。 在内壳和外壳之间形成细长的环形通道。 壳体以滑动接合的方式接收注射器和同心壳体。 在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。 当将该装置应用于皮肤时，壳体和注射器朝向皮肤滑动，并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。 结果，皮肤被横跨内壳张紧，以形成基本上平坦的，拉紧的皮肤目标区域。 与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。

公开(公告)号：US20050217211A1

公开(公告)日：2005-10-06

申请号：US11074454

申请日：2005-03-07

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B29C45/00 ,  B29C45/17 ,  B65B3/00 ,  B65B3/02 ,  B65B7/28 ,  B65B55/06 ,  B65B55/04

CPC classification number: B29C67/004 ,  B29C45/006 ,  B29C45/1701 ,  B29C45/42 ,  B29C65/16 ,  B29C65/1616 ,  B29C66/001 ,  B29C66/0018 ,  B29C66/71 ,  B29C66/91212 ,  B29C66/91216 ,  B29C66/91221 ,  B29C66/91411 ,  B29C66/91431 ,  B29C66/961 ,  B29C2791/005 ,  B29L2031/565 ,  B65B3/003 ,  B65B3/022 ,  B65B55/06 ,  B29C65/00 ,  B29K2023/38

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。