公开(公告)号：US08362070B2

公开(公告)日：2013-01-29

申请号：US12922245

申请日：2010-06-29

Applicant: Shangdong Liang ,  Changshui Xu ,  Yun Gao ,  Guilin Li ,  Jiari Lin ,  Shuangmei Liu ,  Han Liu ,  Jun Zhang ,  Xin Li

Inventor： Shangdong Liang ,  Changshui Xu ,  Yun Gao ,  Guilin Li ,  Jiari Lin ,  Shuangmei Liu ,  Han Liu ,  Jun Zhang ,  Xin Li

IPC: A61K31/35 ,  A61K31/70

CPC classification number: A61K31/352

Abstract: The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.

Abstract translation: 本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。 实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用 的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流 神经性疼痛大鼠根神经节。 实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。 本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用 受体涉及神经系统疾病。

公开(公告)号：US08132112B2

公开(公告)日：2012-03-06

申请号：US12088125

申请日：2007-12-03

Applicant: Xin Li

Inventor： Xin Li

IPC: G06F3/00 ,  G06F15/16

CPC classification number: G06F17/30867 ,  G06F17/30144 ,  G06Q50/01 ,  H04L12/1818

Abstract: One embodiment provides a system of exchanging information between a first party and a second party over a network. The system includes an interface module to prompt a query from a first party by a first key word search and to prompt a query from a second party by a second key word search in the network, a key word comparator module to compare the first and second key word searches, and a chat room admission module to automatically admit the first and second parties to a chat room if the first and second key word searches have substantial similarity. The chat room is embedded into a search result web page.

Abstract translation: 一个实施例提供了通过网络在第一方和第二方之间交换信息的系统。 该系统包括：接口模块，用于通过第一关键字搜索来提示来自第一方的查询，并通过网络中的第二关键字搜索来提示来自第二方的查询;关键字比较器模块，用于比较第一和第二关键字 关键词搜索，以及聊天室准入模块，如果第一和第二关键字搜索具有实质相似性，则自动将第一方和第二方接纳到聊天室。 聊天室嵌入到搜索结果网页中。

公开(公告)号：US20110320437A1

公开(公告)日：2011-12-29

申请号：US12825304

申请日：2010-06-28

Applicant: Yookyung Kim ,  Hongjian Zhao ,  Xin Li ,  Alexandra Levich ,  Tom Chi ,  Ming Sui ,  Yihong Zhao ,  Marc Davis

Inventor： Yookyung Kim ,  Hongjian Zhao ,  Xin Li ,  Alexandra Levich ,  Tom Chi ,  Ming Sui ,  Yihong Zhao ,  Marc Davis

IPC: G06F17/30

CPC classification number: G06F17/3089 ,  G06F17/30522

Abstract: An online article is enhanced by displaying, in association with the article, supplemental content that includes entities that are extracted from the article and/or entities that are related to entities that are extracted from the article. The supplemental content further includes information about each of the entities. The information about an entity may be obtained by searching for the entity in one or more searchable repositories of data. For example, the supplemental content may include, for each entity, video, image, web, and/or news search results. The supplemental content may further include information such as stock quotes, abstracts, maps, scores, and so on. The entities are selected using a variety of analyses and ranking techniques based on contextual factors such as user-specific information, time-sensitive popularity trends, grammatical features, search result quality, and so on. The entities may further be selected for purposes such as generating ad-based revenue.

Abstract translation: 通过与文章相关联地显示包括从文章中提取的实体和/或与从文章中提取的实体相关的实体的补充内容来增强在线文章。 补充内容还包括关于每个实体的信息。 可以通过在一个或多个可搜索的数据库中搜索实体来获得关于实体的信息。 例如，对于每个实体，补充内容可以包括视频，图像，网络和/或新闻搜索结果。 补充内容还可以包括股票报价，摘要，地图，分数等信息。 使用各种基于上下文因素的分析和排序技术来选择实体，诸如用户特定信息，时间敏感的人气趋势，语法特征，搜索结果质量等。 可以进一步选择实体，例如生成基于广告的收入。

公开(公告)号：US08050478B2

公开(公告)日：2011-11-01

申请号：US12345461

申请日：2008-12-29

Applicant: Xin Li ,  Longfei Cong ,  Yu Zhang

Inventor： Xin Li ,  Longfei Cong ,  Yu Zhang

IPC: G06K9/00

CPC classification number: G06T7/149 ,  G06T7/11 ,  G06T2207/10132 ,  G06T2207/30048

Abstract: A method and apparatus for tissue border detection using ultrasonic diagnostic images includes searching an initial central point of a target region in an ultrasonic diagnostic image of a detected target and determining an initial region border based on the initial central point and with the initial central point being a pole, searching a position of a target region border along a polar line across the pole and from an initial region border, and calculating an energy function of intensity distribution at different positions, wherein a position corresponding to a minimum value of the energy function of the intensity distribution is the border position of the target region.

Abstract translation: 使用超声波诊断图像进行组织边界检测的方法和装置包括：在检测到的目标的超声诊断图像中搜索目标区域的初始中心点，并基于初始中心点确定初始区域边界，并且初始中心点为 一个极点，沿着极点和初始区域边界沿极坐标线搜索目标区域边界的位置，以及计算不同位置处的强度分布的能量函数，其中对应于能量函数的最小值的位置 强度分布是目标区域的边界位置。

公开(公告)号：US20110217745A1

公开(公告)日：2011-09-08

申请号：US13061164

申请日：2009-08-31

Applicant: Xin Li ,  Ye Chen

Inventor： Xin Li ,  Ye Chen

IPC: C12P7/10 ,  C12P1/00 ,  C12P7/04 ,  C12N9/14 ,  C12P1/02 ,  C12P1/04

CPC classification number: C12P7/10 ,  C12P19/00 ,  Y02E50/16

Abstract: A process for producing a fermentation product from a lignocellulose-containing material includes pre-treating the lignocellulose-containing material; introducing chitosan or a chitosan-like polymer to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of a hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product.

Abstract translation: 从含木素纤维素的材料生产发酵产物的方法包括预处理含木素纤维素的材料; 将壳聚糖或壳聚糖样聚合物引入到预处理的含木素纤维素的材料中; 将预处理的含木素纤维素材料暴露于有效量的水解酶; 并用发酵生物发酵以产生发酵产物。

公开(公告)号：US20110201917A1

公开(公告)日：2011-08-18

申请号：US13125485

申请日：2009-05-07

Applicant: Xin Li ,  Charles S. Springer ,  William D. Rooney ,  Wei Huang ,  Jingang Xu ,  Ian J. Tagge

Inventor： Xin Li ,  Charles S. Springer ,  William D. Rooney ,  Wei Huang ,  Jingang Xu ,  Ian J. Tagge

IPC: A61B5/055

CPC classification number: A61B5/055 ,  A61B5/4312 ,  G01R33/4828 ,  G01R33/5601 ,  G01R33/5608 ,  G01R33/56366 ,  G06F19/00

Abstract: Embodiments provide a Magnetic Resonance Imaging (MRI) technique and optionally software—collectively referred to as the “shutter-speed” model—to analyze image data of cancer patients. Embodiments provide a minimally invasive, yet precisely accurate, approach to determining whether tumors are malignant or benign by distinguishing the characteristics of contrast reagent activity in benign and malignant tumors. Exemplary embodiments provide MRI measured biomarkers for tumor malignancy determination, effectively eliminating or limiting the false positives suffered by existing MRI techniques.

Abstract translation: 实施例提供磁共振成像（MRI）技术和可选地软件统称为“快门速度”模型，以分析癌症患者的图像数据。 实施例提供了通过区分良性和恶性肿瘤中造影剂活性的特征来确定肿瘤是恶性还是良性的微创但精确准确的方法。 示例性实施方案提供用于肿瘤恶性肿瘤测定的MRI测量的生物标志物，有效地消除或限制现有MRI技术所遭受的假阳性。

公开(公告)号：US07949672B2

公开(公告)日：2011-05-24

申请号：US12136279

申请日：2008-06-10

Applicant: Ya Zhang ,  Srinivas Vadrevu ,  Belle Tseng ,  Gordon Guo-Zheng Sun ,  Xin Li

Inventor： Ya Zhang ,  Srinivas Vadrevu ,  Belle Tseng ,  Gordon Guo-Zheng Sun ,  Xin Li

IPC: G06F7/00 ,  G06F17/30

CPC classification number: G06F17/3087

Abstract: A system for determining the intent of query that includes a search engine that receives a first search query, a query/click log module configured to store log data associated with the first search query; and a computational module that generates metric values associated with the first search query based on the log data and that determines that the first search query is one of a regional specific query or a global query based on the metric values, where the metric values reflect a likelihood of local intent of the first search query, and where the search engine provides search results selected in part based on the metric values.

Abstract translation: 一种用于确定查询意图的系统，包括接收第一搜索查询的搜索引擎，被配置为存储与第一搜索查询相关联的日志数据的查询/点击日志模块; 以及计算模块，其基于所述日志数据生成与所述第一搜索查询相关联的度量值，并且基于所述度量值确定所述第一搜索查询是区域特定查询或全局查询之一，其中所述度量值反映 第一搜索查询的本地意图的可能性，以及搜索引擎提供基于度量值部分地选择的搜索结果的位置。

公开(公告)号：US07945868B2

公开(公告)日：2011-05-17

申请号：US12243176

申请日：2008-10-01

Applicant: Lawrence T. Pileggi ,  Xin Li

Inventor： Lawrence T. Pileggi ,  Xin Li

IPC: G06F17/50

CPC classification number: H03J5/244 ,  H03J2200/10

Abstract: The invention discloses a method for tuning nano-scale analog-circuit designs in order to reduce random-device mismatches and optimize said design, where nano-scale devices potentially have large-scale process variations. The method includes providing a tunable circuit topology, wherein each nano-scale device comprises a single component or comprises multiple parallel components. Each component is decomposed into multiple discrete sub-components, wherein each said sub-component either operates in parallel with other like components to effectively operate like one bigger component. The sub-components are subjected to a dynamic-programming process to adaptively select the sub-components to be kept operational, while configuring the nonselected sub-components to be nonoperational, based on the measurement of at least one operational parameter.

Abstract translation: 本发明公开了一种用于调整纳米尺度模拟电路设计的方法，以便减少随机设备不匹配并优化所述设计，其中纳米级器件潜在地具有大规模工艺变化。 该方法包括提供可调谐电路拓扑，其中每个纳米尺度装置包括单个部件或包括多个并联部件。 每个组件被分解成多个离散的子组件，其中每个所述子组件或者与其他类似组件并行操作，以像一个较大的组件一样有效地操作。 基于至少一个操作参数的测量，子组件经受动态编程过程以自适应地选择要保持操作的子组件，同时将非选择子组件配置为非操作。

公开(公告)号：US20100114859A1

公开(公告)日：2010-05-06

申请号：US12263368

申请日：2008-10-31

Applicant: Xin Li ,  Eric Zhao

Inventor： Xin Li ,  Eric Zhao

IPC: G06F7/10 ,  G06F17/30

CPC classification number: G06F17/30696 ,  G06F17/30719

Abstract: An improved system and method for generating an online summary of a collection of documents is provided. A list of documents may be received, and the titles of the list of documents may be obtained. A set of terms that frequently occur in the titles of the documents may be iteratively expanded and overlapping phrases may be merged until there may be no more terms that occur in the titles with a frequency that exceeds a predefined threshold. In an embodiment, an article summarizer operably coupled to a search engine may be provided to generate a summary of a list of references to web pages in search results using titles of the web pages. The summary of the web pages may then be sent with the list of references to the web pages as search results to a client device for display to a user.

Abstract translation: 提供了一种用于生成文档集合的在线摘要的改进的系统和方法。 可以收到文件清单，并且可以获得文件清单的标题。 频繁出现在文档标题中的一组术语可以被迭代地扩展，并且重叠的短语可以被合并，直到在具有超过预定阈值的频率的标题中不再有术语出现。 在一个实施例中，可以提供可操作地耦合到搜索引擎的文章总结器，以使用网页的标题来生成对搜索结果中对网页的引用的列表的摘要。 然后可以将网页的摘要作为搜索结果发送到作为搜索结果的网页的引用列表，以便向用户显示。

公开(公告)号：US07693865B2

公开(公告)日：2010-04-06

申请号：US11514076

申请日：2006-08-30

Applicant: Yumao Lu ,  Fuchun Peng ,  Xin Li ,  Nawaaz Ahmed

Inventor： Yumao Lu ,  Fuchun Peng ,  Xin Li ,  Nawaaz Ahmed

IPC: G06F17/00

CPC classification number: G06K9/623 ,  G06F17/30707 ,  G06F17/30864 ,  G06K9/6278

Abstract: To accurately classify a query as navigational, thousands of available features are explored, extracted from major commercial search engine results, user Web search click data, query log, and the whole Web's relational content. To obtain the most useful features for navigational query identification, a three level system is used which integrates feature generation, feature integration, and feature selection in a pipeline. Because feature selection plays a key role in classification methodologies, the best feature selection method is coupled with the best classification approach to achieve the best performance for identifying navigational queries. According to one embodiment, linear Support Vector Machine (SVM) is used to rank features and the top ranked features are fed into a Stochastic Gradient Boosting Tree (SGBT) classification method for identifying whether or not a particular query is a navigational query.

Abstract translation: 为了将查询精确地分类为导航，从主要商业搜索引擎结果，用户Web搜索点击数据，查询日志和整个Web的关系内容中提取出数千种可用功能。 为了获得导航查询识别最有用的功能，使用了一个三级系统，将特征生成，特征集成和特征选择集成在一条流水线中。 因为特征选择在分类方法中起着关键作用，因此最好的特征选择方法与最佳分类方法相结合，以实现识别导航查询的最佳性能。 根据一个实施例，使用线性支持向量机（SVM）对特征进行排序，并且将顶级特征馈送到用于识别特定查询是否是导航查询的随机渐变增强树（SGBT）分类方法中。