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公开(公告)号：US20240368583A1
公开(公告)日：2024-11-07
申请号：US18765281
申请日：2024-07-07
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David MARGULIES , Leila MOTIEI , Suraj Uttamrao Toraskar , Abhirup Majumdar
IPC: C12N15/10 , C12N1/20 , C12N15/11 , G01N33/574 , G01N33/58
Abstract: The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.
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公开(公告)号：US12129475B2
公开(公告)日：2024-10-29
申请号：US16484200
申请日：2018-02-08
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. , Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventor： Asaph Aharoni , Prashant Sonawane , Pablo D. Cardenas , Burdman Saul
CPC classification number: C12N15/8279 , C12N9/0006 , C12N9/0071 , C12N15/8218 , C12N15/8243
Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Methods of producing these genetically modified plants are also disclosed.
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公开(公告)号：US20240346354A1
公开(公告)日：2024-10-17
申请号：US18299827
申请日：2023-04-13
Inventor： Gil SEMO , Ziv AQUA , Oded MELAMED , Dan CHARASH , Serge ROSENBLUM , Barak DAYAN
CPC classification number: G06N10/40 , G06N10/20 , H01L29/66977 , H01L33/06
Abstract: Systems and methods for a quantum computing include a plurality of photonic processing stages, a plurality of heralding-free connections, and circuitry configured to regulate photon flow between adjacent stages such that decisions about stage settings or flow between adjacent stages are free of input from a previous stage. Each heralding-free connection is located between adjacent photonic processing stages. Each photonic processing stage includes at least two of an optical switch, a beam splitter, a waveguide or a photon generator. Methods include transmitting or receiving a plurality of photons via a plurality of heralding-free connections, and regulating photon flow between adjacent stages such that decisions about stage settings or flow between adjacent stages are free of input from a previous stage.
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公开(公告)号：US20240338587A1
公开(公告)日：2024-10-10
申请号：US18300658
申请日：2023-04-14
Inventor： Gil SEMO , Ziv AQUA , Oded MELAMED , Dan CHARASH , Serge ROSENBLUM , Barak DAYAN
IPC: G06N10/40
CPC classification number: G06N10/40
Abstract: A quantum computing system, method and computer readable medium involve a vacuum chamber, an atom source input associated with the vacuum chamber, a Photonic Integrated Circuit (PIC) having an interaction region configured to interact with an atom from the atom source, a coupling location for atom positioning, a trapping laser for trapping the atom in the coupling location, an excitation laser for manipulating an electronic state or a nuclear state of the atom, a waveguide for guiding input light to the coupling location, and an output channel for directing quantum light generated at the coupling location, out of the vacuum chamber as a resource for quantum computing. The coupling location is associated with the PIC, and the interaction region of the PIC is arranged for at least partial exposure to the vacuum.
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公开(公告)号：US20240325456A1
公开(公告)日：2024-10-03
申请号：US18736635
申请日：2024-06-07
Applicant: Yeda Research and Development Co. Ltd. , Board of Regents, The University of Texas System
Inventor： Yair REISNER , Chava ROSEN , Elias SHEZEN , Ran ORGAD , Irit MILMAN KRENTSIS , Xiaohua SU , Raj Kumar YADAV , Yangxi ZHENG
CPC classification number: A61K35/42 , C12N5/0688 , C12N2501/11 , C12N2501/165 , C12N2501/727 , C12N2509/00
Abstract: Multipotent lung progenitor cells for lung regeneration are provided. Accordingly, there are provided methods of expanding in culture an isolated population of pulmonary cells, methods of qualifying suitability of an isolated population of pulmonary cells for administration to a subject in need thereof, and methods of generating an isolated population of pulmonary cells comprising selecting a cell population being double positive for expression of epithelial and endothelial cell markers. Also provided are isolated populations of pulmonary cells, pharmaceutical compositions comprising same and uses of same.
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Patent Agency Ranking
公开(公告)号：US20240315192A1
公开(公告)日：2024-09-26
申请号：US18735258
申请日：2024-06-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： Asaph AHARONI , Prashant SONAWANE , Maxim ITKIN , Adam JOZWIAK
CPC classification number: A01H6/82 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.
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公开(公告)号：US20240256934A1
公开(公告)日：2024-08-01
申请号：US18299819
申请日：2023-04-13
Inventor： Gil SEMO , Ziv AQUA , Oded MELAMED , Dan CHARASH , Serge ROSENBLUM , Barak DAYAN
IPC: G06N10/40
CPC classification number: G06N10/40
Abstract: A quantum computing method includes initializing a state of a resonator-coupled quantum emitter, receiving at least two photonic graph states, selecting at least one photon from each graph state, feeding the selected photons through an entangling gate via the resonator-coupled quantum emitter, and disentangling the resonator-coupled quantum emitter from the selected photons. Each of the at least two photonic graph states contains at least two photons. The disentangling includes at least one of detecting the state of the resonator-coupled quantum emitter or mapping the state of the resonator-coupled quantum emitter to a state of an additional photon.
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公开(公告)号：US12041907B2
公开(公告)日：2024-07-23
申请号：US17272685
申请日：2019-09-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph Aharoni , Prashant Sonawane , Maxim Itkin , Adam Jozwiak
CPC classification number: A01H6/82 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.
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公开(公告)号：US20240228976A1
公开(公告)日：2024-07-11
申请号：US18421666
申请日：2024-01-24
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ravid Straussman , Nancy Gavert
IPC: C12N5/09 , A61K31/138 , A61K31/337 , A61K31/439 , A61K31/4545 , A61K31/4748 , A61K31/502 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61P35/00 , C12M1/12 , G01N33/50
CPC classification number: C12N5/0693 , A61K31/138 , A61K31/337 , A61K31/439 , A61K31/4545 , A61K31/4748 , A61K31/502 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61P35/00 , C12M25/00 , G01N33/5011 , C12N2503/02 , C12N2503/04 , C12N2513/00
Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.
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210.发明公开公开(公告)号：US20240197746A1
公开(公告)日：2024-06-20
申请号：US18589576
申请日：2024-02-28
Applicant: Yeda Research and Development Co. Ltd. , The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Ravid STRAUSSMAN , Nancy GAVERT , Yaara ZWANG
IPC: A61K31/52 , A61K31/4184 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/517 , A61P35/00 , C12N5/071 , C12N5/09 , G01N33/50
CPC classification number: A61K31/52 , A61K31/4184 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/517 , A61P35/00 , C12N5/0679 , C12N5/0693 , G01N33/5011 , C12N2500/02 , C12N2527/00 , G01N2333/9121
Abstract: A method of treating colorectal cancer (CRC) is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a Mitogen/extracellular signal-regulated kinase (MEK) inhibitor and a SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase (SRC) inhibitor, wherein cancer cells of the subject express an amount of SRC p419 above a predetermined level and do not express a KRAS G12 mutation, thereby treating the CRC.
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