公开(公告)号：US12280177B2

公开(公告)日：2025-04-22

申请号：US17388652

申请日：2021-07-29

Applicant: Wisconsin Alumni Research Foundation ,  ARKANSAS STATE UNIVERSITY—JONESBORO ,  Worcester Polytechnic Institute

Inventor： William L. Murphy ,  Gianluca Fontana ,  Joshua Gershlak ,  Glenn Gaudette ,  Pam Weathers ,  Tanja Dominko ,  Marsha Rolle ,  Sarah Hernandez ,  Carol Cramer ,  Luis Fabircio Medina-Bolivar ,  Bernard Binder

IPC: A61L27/36 ,  A61L27/12 ,  A61L27/22 ,  A61L27/38 ,  A61L27/54 ,  C12N5/00 ,  C12N5/04

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

公开(公告)号：US20250033211A1

公开(公告)日：2025-01-30

申请号：US18787513

申请日：2024-07-29

Applicant: Worcester Polytechnic Institute

Inventor： Sean McGovern ,  Jing Xiao

IPC: B25J9/16 ,  B25J9/02

Abstract: A generalized approach and methodology for addressing surface traversal and coverage of a 3 Dimensional (3-D) object receives a 3-D wireframe or similar Cartesian based representation, converts the 3-D representation to a u,v system or mapping. Often employed for texture mapping, u.v grid systems define a two dimensional form of an object, often referred to as “unfolding” of an object. Configurations herein define a u.v grid system directly on the 3-D object for computing a coverage path, typically an aggregation of raster passes to traverse an entire 3-D surface. From a robotic manipulator, a 3D freeform surface, and task constraints, the approach determines whether there exists a feasible continuous motion plan to cover the surface, and if so, produces a uniform coverage path that best satisfies task constraints resulting from the physical object and robot kinematics.

公开(公告)号：US20250013145A1

公开(公告)日：2025-01-09

申请号：US17971393

申请日：2022-10-21

Applicant: Worcester Polytechnic Institute

Inventor： Pratap Rao ,  John S. Berg ,  Maryam M. Shalmani

IPC: G03F7/00 ,  B41F19/00 ,  H05K3/12

Abstract: Nanoimprint lithography forms a microfeature array on a substrate responsive to inkjet printing techniques for high resolution printing of circuit elements and other features with highly accurate fidelity to predetermined boundaries. The microfeature array is defined by micropillars formed between intersecting microchannels in the substrate. The micropillars are responsive to a sequence of ink droplets in a highly controlled and predictable manner based on the droplet volume, droplet spacing and temperature. The flow of liquid ink is restrained by the micropillars for pinning the ink for avoiding uncontrolled ink flow as occurs on a flat surface. Subsequent layers of deposited ink tend to follow pining of previous layers, allowing an iterative buildup of layers for forming a trace of sufficient thickness and a high aspect ratio allowing traces extending above the depth of the microchannels for aiding communication with surface mount components.

公开(公告)号：US20240423550A1

公开(公告)日：2024-12-26

申请号：US18598664

申请日：2024-03-07

Applicant: Worcester Polytechnic Institute

Inventor： Songbai JI ,  Shaoju WU

IPC: A61B5/00 ,  A61B5/11

Abstract: A concussion detection system comprises a kinematic detection device configured to be carried by a head of a user and a concussion detection device disposed in electrical communication with the kinematic detection device. The concussion detection device comprises a controller configured to: receive kinematic data from the kinematic detection device, the kinematic data associated with a head impact of the user, apply the kinematic data to a strain prediction engine to generate a strain identifier associated with the head impact and a concussion risk assessment associated with the strain identifier, and output the concussion risk assessment based upon the strain identifier and configured to identify a concussion risk associated with the head impact. The concussion detection device can assess concussion risk in the user for an individual impact, or based on a history of multiple head impacts, and can further take into account head or brain size differences.

公开(公告)号：US20240307005A1

公开(公告)日：2024-09-19

申请号：US18605287

申请日：2024-03-14

Applicant: Worcester Polytechnic Institute

Inventor： Rajesh S. Kasbekar ,  Edward A. Clancy

IPC: A61B5/00 ,  A61B5/021 ,  A61B5/352 ,  G16H10/60 ,  G16H50/70

CPC classification number: A61B5/7267 ,  A61B5/02125 ,  A61B5/352 ,  A61B5/681 ,  G16H10/60 ,  G16H50/70

Abstract: This disclosure relates to systems and processes for estimating blood pressure. Systems described herein comprise at least one sensor for measuring at least one waveform related to blood pressure from a patient; at least one processor; and at least one computer-readable storage medium having encoded thereon executable instructions to carry out a method comprising: receiving, from the at least one sensor, the at least one waveform and determining one or more features comprising at least one or more temporal features and one or more morphology features; and analyzing the one or more features using one or more trained models to determine one or more blood pressure (BP) value associated with the patient; and outputting the one or more BP value determined for the patient based on the received one or more features. The system allows for continuous and noninvasive calculations of a blood pressure to the patient or other users.

公开(公告)号：US20240299009A1

公开(公告)日：2024-09-12

申请号：US18667740

申请日：2024-05-17

Applicant: Worcester Polytechnic Institute

Inventor： Haichong Zhang ,  Shang Gao

IPC: A61B8/00 ,  A61B5/00 ,  A61B8/12 ,  A61B17/00 ,  A61B18/14 ,  A61B90/00

CPC classification number: A61B8/4461 ,  A61B5/0095 ,  A61B8/12 ,  A61B8/445 ,  A61B18/1492 ,  A61B2017/00106 ,  A61B2090/3782

Abstract: A photoacoustic (PA) sensor employs a linear deployment of an illumination source and a corresponding ultrasonic receiver for defining an imaging plane for rendering a PA image of a surgical or diagnostic region. A pair of illumination sources emanates from cladding removal of respective optical fibers, and irradiates in alignment with a side firing ultrasonic (US) array for receiving the induced PA signals. The US array extends longitudinally and parallel to the illumination sources, and an overlap of the respective irradiation regions extends from the illumination sources lies within a sensing region of the US array for defining an imaging plane captured by the US sensor for rendering on a visual device, often in conjunction with an ablation antenna or diagnostic probe for providing concurrent imaging during a surgical procedure.

公开(公告)号：US20240226212A1

公开(公告)日：2024-07-11

申请号：US18404140

申请日：2024-01-04

Applicant: Worcester Polytechnic Institute

Inventor： Reeta Rao ,  Eric M. Young ,  Lohith Kunyeit ,  K. A. Anu-Appaiah ,  Joseph H. Collins

IPC: A61K36/064 ,  A01N63/32 ,  A01P3/00 ,  A61P31/10

CPC classification number: A61K36/064 ,  A01N63/32 ,  A01P3/00 ,  A61P31/10

Abstract: A formulated composition for treating or preventing epithelial fungal infection and correcting dysbiosis in or on a subject provides an effective dose of yeast cells containing a plurality of genes encoding functions of tolerance to a high temperature, tolerance to high and low pH, adherence to cells of the subject, and biosynthesis of amino acid alcohols.

公开(公告)号：US20240218271A1

公开(公告)日：2024-07-04

申请号：US18540345

申请日：2023-12-14

Applicant: Worcester Polytechnic Institute

Inventor： Michael Timko ,  Alex R. Maag ,  Elizabeth Belden ,  Geoffrey A. Tompsett ,  Andrew R. Teixeira ,  Aidin Panahi ,  Andrew Charlebois ,  Skyler Kauffman

IPC: C10G69/06 ,  C02F11/06 ,  C10B53/02 ,  C10B53/07

CPC classification number: C10G69/06 ,  C02F11/06 ,  C10B53/02 ,  C10B53/07 ,  C10G2300/1003 ,  C10G2300/80

Abstract: A waste stream of organic matter such as sewage, plant and plastic matter is received for recycling and treated with high temperature and pressure to generate useful organic products such as bio-oil and gas. Byproducts such as char and an aqueous phase including water can be selectively recycled or beingly discarded. An oxidant added to a reactor containing waste from the waste stream facilitates an autothermal reaction under the temperature and pressure applied to the reactor, boosting the temperature slightly from the reactions therein. The reactor generates useful hydrocarbons such as bio-oil resulting from disruption of organic bonds. A combination of oxidation and radical initiation results from the oxidant, and provides an increased yield of bio-oil while decreasing char when compared to temperature and pressure alone. A stoichiometric quantity of the oxidant limits complete conversion of carbon into carbon dioxide by limiting available oxygen and therefore favoring hydrocarbon formation.

公开(公告)号：US20240207219A1

公开(公告)日：2024-06-27

申请号：US18392419

申请日：2023-12-21

Applicant: Worcester Polytechnic Institute ,  The Penn State Research Foundation

Inventor： Scarlet S. Shell ,  Pamela Weathers ,  Joshua J. Kellogg

IPC: A61K31/352 ,  A61K36/282 ,  A61K45/06 ,  A61K49/00 ,  A61P31/06

CPC classification number: A61K31/352 ,  A61K36/282 ,  A61K45/06 ,  A61K49/0008 ,  A61P31/06 ,  A61K2236/15 ,  A61K2236/39

Abstract: Artemisia annua and A. afra dichloromethane extracts contain bactericidal activity against Mycobacterium tuberculosis (Mtb) strain mc26230 under natural infection stress conditions: carbon source metabolism (glycerol, dextrose, and cholesterol) and hypoxia. Significant bactericidal activity against Mtb was observed regardless of carbon source. Extracts from A. afra showed the highest bactericidal activity against Mtb for tested carbon sources, and A. annua bactericidal activity was greatest against Mtb in minimal media with glycerol. A. annua and A. afra. extracts were bactericidal against Mtb under hypoxic conditions. Growth was halted and viability diminished several logs-fold under hypoxic conditions in the presence of each extract. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb than artemisinin, indicative of phytochemicals in A. afra with unique modes of action. Biochemometric analysis of A. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230.

公开(公告)号：US20240130808A1

公开(公告)日：2024-04-25

申请号：US18400038

申请日：2023-12-29

Applicant: Worcester Polytechnic Institute ,  University of Massachusetts

Inventor： Gregory S. Fischer ,  Gregory A. Cole ,  Julie G. Pilitsis

IPC: A61B34/30

CPC classification number: A61B34/30 ,  A61B2034/301 ,  A61B2090/374

Abstract: A system and method for image guided assisted medical procedures using modular units, such that a controller, under the direction of a computer and imaging device, can be utilized to drive and track low cost, purpose specific manipulators. The system utilizes modular actuators, self tracking, and linkages. The systems can be optimized at a low cost for most effectively performing surgical procedures, while reusing the more costly components of the system, e.g. the control, driving, and tracking systems. The system and method may utilize MRI real time guidance during the above procedures.