公开(公告)号：US20200340001A1

公开(公告)日：2020-10-29

申请号：US16857089

申请日：2020-04-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sung Su LIM ,  Seul Gi SHIN ,  Yun Kyung KIM

IPC: C12N15/64 ,  C07K14/47

Abstract: The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.

公开(公告)号：US10815565B2

公开(公告)日：2020-10-27

申请号：US16198663

申请日：2018-11-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jaehyun Park ,  Yumin Sim ,  Jaikyeong Kim

IPC: C23C16/26 ,  C23C16/02 ,  G02F1/01 ,  G02F1/00

Abstract: A method for synthesizing a graphene pattern includes physically adhering a catalyst block including a catalyst material, which is a gamma-alumina thin film, to a portion of a growth substrate to form a flat interface between the catalyst block and the growth substrate; forming a graphene thin film selectively at the flat interface between the catalyst block and the growth substrate in an atmosphere including a carbon source and a growth inhibitor containing oxygen, and applying a force to physically separate the catalyst block from the graphene thin film and the growth substrate, wherein carbon atoms from the carbon source are diffused along the flat interface and the growth inhibitor is substantially blocked by a diffusion barrier formed by the flat interface so that the graphene thin film is selectively formed at the flat interface.

公开(公告)号：US10803882B2

公开(公告)日：2020-10-13

申请号：US16546440

申请日：2019-08-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Wan Shim ,  Heon Phil Ha

IPC: G10L21/028 ,  G10L25/30 ,  H04R1/34 ,  H04R1/40 ,  H04R3/00

Abstract: A sound source separating apparatus may include: a housing; a plurality of microphones positioned on the housing; a plurality of sound guides positioned on the housing to be adjacent to the plurality of microphones, and configured to guide sound to the plurality of microphones and to generate a difference between a plurality of sound information respectively arriving at the plurality of microphones according to a direction of a sound source; and a processor configured to separate the sound source according to the direction of the sound source based on the plurality of sound information received by the plurality of microphones.

公开(公告)号：US10793476B2

公开(公告)日：2020-10-06

申请号：US16198878

申请日：2018-11-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Hyeok Shim ,  Tae Jun Ha ,  Jin Yoo Suh

IPC: C04B35/00 ,  C04B35/58 ,  C04B35/626 ,  C01F17/00

Abstract: A method of preparing cerium boride powder, according to the present invention, includes a first step for generating mixed powder by mixing at least one selected from among cerium chloride (CeCl3) powder and cerium oxide (CeO2) powder, at least one selected from among magnesium hydride (MgH2) powder and magnesium (Mg) powder, and boron oxide (B2O3) powder, a second step for generating composite powder including cerium boride (CexBy) and at least one selected from among magnesium oxide (MgO) and magnesium chloride (MgCl2), by causing reaction in the mixed powder at room temperature based on a ball milling process, and a third step for selectively depositing cerium boride powder by dispersing the composite powder in a solution.

公开(公告)号：US10780414B2

公开(公告)日：2020-09-22

申请号：US15933191

申请日：2018-03-22

Applicant: Korea Institute of Science and Technology

Inventor： Jong-soo Jurng ,  Hyoun-duk Jung ,  Young-haeng Lee

IPC: B01J20/10 ,  C01B33/12 ,  B01J20/28 ,  B01J20/32 ,  C10L3/10 ,  B01D53/04 ,  B01D53/02

Abstract: A method of preparing an adsorbent for removing siloxane, in which the method includes mixing a silica particle and an OH compound to bond OH functional groups to the silica particle; measuring percentage by weight of OH bonded to the silica particle; calculating a bonding number and spacing of the OH functional groups by the percentage by weight of OH bonded to the silica particle; performing an evaluation of an adsorption rate and desorption rate of the silica particle to which the OH functional groups, of which the bonding number and spacing are calculated, are bonded; and adjusting the bonding number of the OH functional groups in the silica particle according to the evaluation.

公开(公告)号：US10751360B1

公开(公告)日：2020-08-25

申请号：US16842310

申请日：2020-04-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heh-In Im ,  Byung Sun Kim

IPC: A61K48/00 ,  C07H21/04 ,  A61K31/7105 ,  C12N15/86 ,  A61P25/34 ,  C12N15/113 ,  A61K9/00

Abstract: Disclosed is a pharmaceutical composition for preventing or treating nicotine addiction or withdrawal symptoms. The pharmaceutical composition includes miR-137 as an active ingredient. Overexpression of miR-137 in an animal model having nicotine addiction or withdrawal symptoms results in relief, prevention or amelioration of the symptoms. Therefore, the use of miR-137 contributes to the prevention or treatment of nicotine addiction or withdrawal symptoms and is expected to be useful for developing relevant therapeutic agents.

公开(公告)号：US10746847B2

公开(公告)日：2020-08-18

申请号：US16476901

申请日：2017-12-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taikjin Lee ,  Youngmin Jhon ,  Jaehun Kim ,  Boseon Yu ,  Beomju Shin ,  Jaewon Bang

IPC: G01S5/14 ,  H04W4/029 ,  G01S5/00 ,  G01S5/02 ,  G01S11/06 ,  G01S19/01 ,  H04W88/18 ,  G01C21/20

Abstract: The present invention relates to wireless localization method and apparatus of high accuracy, and measures strength of at least one signal that is transmitted from at least one fixed node, estimates a relative position of a moving node, generates a change pattern of at least one signal strength according to relative changes in positions of the moving node over a plurality of time points from at least one signal strength and the relative position of the moving node, and estimates an absolute position of the moving node, based on a comparison between the change pattern of the at least one signal strength and a map of a distribution pattern shape of signal strength in a region where the moving node is located. Accordingly, it is possible to accurately estimate a position of a moving node using a radio signal which not only accurately estimates the position of the moving node even in a change of wireless environment but also has almost no change in signal strength over a wide region.

公开(公告)号：US20200248141A1

公开(公告)日：2020-08-06

申请号：US16601853

申请日：2019-10-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  HyeRan GWAK ,  Eun Gyeong YANG

IPC: C12N5/0786 ,  A61K35/15

Abstract: Provided are a composition and a kit for reprogramming cancer associated fibroblasts (CAFs) into macrophages, and a method of using the same. According to a method of reprogramming CAFs according to an aspect, macrophages may be prepared with a high yield in a short period of time, and the tumor microenvironment may be suppressed and macrophages produced by reprogramming CAF may elimininate cancer cells. Therefore, the macrophages may be usefully applied as an anticancer agent or an anticancer adjuvant.

公开(公告)号：US10736250B1

公开(公告)日：2020-08-04

申请号：US16679289

申请日：2019-11-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Woo Kim ,  Jong Han Choi

IPC: H05K9/00 ,  B32B15/02 ,  B32B37/04

Abstract: A method of manufacturing a transparent flexible silver nanowire-based conducting film and a transparent flexible silver nanowire-based conducting film are provided. The method includes coating conductive nanowires, which shield and absorb electromagnetic interference, on a flexible substrate, sintering the conductive nanowires using a wet sintering process, and coating a polymer layer in which graphene flakes are dispersed on the flexible substrate with the conductive nanowires formed thereon.

公开(公告)号：US20200239944A1

公开(公告)日：2020-07-30

申请号：US16628346

申请日：2018-07-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Kyung KIM ,  Junsun KIM

IPC: C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6853

Abstract: In the present invention, when amplifying a nucleic acid by incorporating at least one primer among a forward primer and reverse primer and/or a probe in an upper critical solution temperature (UCST) particle, or when amplifying a nucleic acid by incorporating at least one primer among the forward primer and reverse primer and/or a probe in a UCST particle and fixing to a hydrogel fine particle, same the primer or probe comprised in the UCST particle can be discharged within a certain temperature range. Accordingly, the formation of primer dimers can be prevented while also achieving excellent PCR amplification efficiency.