公开(公告)号：US20180214600A1

公开(公告)日：2018-08-02

申请号：US15748302

申请日：2016-07-29

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. ,  SHARKLET TECHNOLOGIES, INC.

Inventor： Chelsea Marie MAGIN ,  Anthony B. BRENNAN

IPC: A61L27/18 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61L27/18 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/58 ,  A61L2400/18 ,  A61L2430/38

Abstract: Disclosed herein is an article including a substrate having at least one surface that has a texture and a first type of growing cells, wherein an average length of features that form the texture is operative to facilitate cell growth, cell orientation, cell morphology and cell differentiation. Disclosed herein too is a method including forming a first layer of a polymeric material on at least one surface of a substrate; texturing the first layer to form a textured first layer; and forming a first type of growing cells on the textured first layer, wherein an average length of features that form the textured first layer is operative to facilitate cell growth, cell orientation, cell morphology and cell differentiation.

公开(公告)号：US20180207318A1

公开(公告)日：2018-07-26

申请号：US15744942

申请日：2016-07-14

Applicant: University of Florida Research Foundation, Inc.

Inventor： CHRISTINE E. SCHMIDT ,  REBECCA ANN WACHS ,  ROBERT CHASE CORNELISON

IPC: A61L27/36 ,  C12N5/0793

CPC classification number: A61L27/3633 ,  A61K35/30 ,  A61K35/32 ,  A61K35/42 ,  A61L27/3687 ,  A61L27/54 ,  A61L2430/40 ,  C12N5/0619 ,  C12N2533/90

Abstract: Provided herein are methods of producing an acellular tissue product wherein the method can include the step of inducing apoptosis and washing the tissue after induction of apoptosis with a tonic solution. Also provided herein are acellular tissue products produced by the methods provided herein and methods of administering the acellular tissue products to a subject in need thereof.

公开(公告)号：US20180204656A1

公开(公告)日：2018-07-19

申请号：US15910052

申请日：2018-03-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： James F. Klausner ,  Renwei Mei ,  Ayyoub Mehdizadeh Momen ,  Kyle Allen

IPC: H01F1/01 ,  H01F41/00 ,  C04B35/515 ,  C01B32/50 ,  B01J37/00 ,  B01J23/745 ,  B01J37/02

CPC classification number: H01F1/01 ,  B01J23/745 ,  B01J37/0009 ,  B01J37/0221 ,  C01B32/50 ,  C04B35/515 ,  C04B38/0038 ,  H01F41/00 ,  C04B35/01 ,  C04B38/0096

Abstract: Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and a uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.

公开(公告)号：US10023920B2

公开(公告)日：2018-07-17

申请号：US15667082

申请日：2017-08-02

Applicant: The United States of America, as represented by the Secretary of Agriculture ,  University of Florida Research Foundation, Inc.

Inventor： Yong Ping Duan ,  Lijuan Zhou ,  John Kent Morgan

IPC: C12Q1/68 ,  C12Q1/689

Abstract: DNA amplification methods using novel primers obtained from the novel genes hyvI and hyvII from the Candidatus Liberibacter asiaticus genome are useful for detecting Ca. L. species in plants and insect hosts.

公开(公告)号：US09994535B2

公开(公告)日：2018-06-12

申请号：US15428232

申请日：2017-02-09

Applicant: University of Florida Research Foundation, Inc.

Inventor： Raymond J. Bergeron, Jr.

IPC: C07D277/12 ,  A61K31/426

CPC classification number: C07D277/12 ,  A61K31/426 ,  C07B2200/07 ,  C07D277/10

Abstract: Compounds represented by structural formulas described herein, such as Structural Formula (I): or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.

公开(公告)号：US09992989B2

公开(公告)日：2018-06-12

申请号：US15382072

申请日：2016-12-16

Applicant: University of Florida Research Foundation, Inc.

Inventor： Philip G. Koehler ,  Ephraim V. Ragasa ,  Roberto M. Pereira

IPC: A01M1/20 ,  A01M1/04 ,  A01M1/10 ,  A01N43/40 ,  A01N53/00 ,  A01N47/22

CPC classification number: A01M1/2016 ,  A01M1/04 ,  A01M1/106 ,  A01M1/20 ,  A01M1/2005 ,  A01M1/2011 ,  A01N37/38 ,  A01N43/22 ,  A01N43/40 ,  A01N47/22 ,  A01N49/00 ,  A01N53/00 ,  A01N57/16 ,  A01N63/00 ,  Y02A50/356 ,  Y02A50/371 ,  A01N25/10 ,  A01N25/34 ,  A01N31/14 ,  A01N37/32 ,  A01N43/30

Abstract: Dual action lethal containers, systems, methods, compositions and formulas used to kill mosquitoes and their larvae. The containers can have separate interior larvicidal and adulticidal coatings separated from each other by horizontal water line holes in the container. Another container can use a novel combined coating of a larvicidal and adulticidal coating. Unique compositions of adulticidal coatings, larvicidal coatings and combined adulticidal and larvicidal coatings can be used as liners.

公开(公告)号：US20180153469A1

公开(公告)日：2018-06-07

申请号：US15573548

申请日：2016-05-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： YONG KYU YOON ,  XIAOYU CHENG ,  GLORIA JUNG A. KIM

IPC: A61B5/00 ,  A61B5/22 ,  H01Q9/16 ,  H01Q1/27

CPC classification number: A61B5/682 ,  A61B5/0004 ,  A61B5/0015 ,  A61B5/228 ,  A61B5/4557 ,  A61B2560/0214 ,  A61B2562/0247 ,  A61C19/04 ,  H01Q1/273 ,  H01Q9/16 ,  H02N2/181

Abstract: Various examples of methods, systems, and apparatus are provided for monitoring using an improved mouth guard apparatus. In one example, a battery-free diagnostic mouth guard includes a biting force-voltage transducer comprising a piezoelectric film; a compact resonance tank comprising a wireless sensor; and a transmitting antenna for transmitting sensing data. A piezo-voltage from the biting force-voltage transducer can bias a varactor diode loaded on the wireless sensor whose response frequency is tuned due to a capacitance change of the varactor diode. In some implementations, an external processing equipment can wirelessly detect a frequency shift of the varactor diode integrated resonator. In another example, a method includes detecting a biting force via a biting force-voltage transducer; biasing a varactor diode with a voltage from the transducer; tuning a response frequency of a split ring resonator using a capacitance change of the varactor diode; and emitting sensing data at the response frequency.

公开(公告)号：US09951111B2

公开(公告)日：2018-04-24

申请号：US14103564

申请日：2013-12-11

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Howard M. Johnson ,  Chulbul M. Ahmed

IPC: A61K39/00 ,  A61K38/21 ,  C07H21/04 ,  A61K9/127 ,  C07K14/47 ,  A61K38/16 ,  A61K38/17 ,  A61K31/7088 ,  A61K45/06 ,  C07K16/28 ,  C12N15/113

CPC classification number: C07K14/47 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/21 ,  A61K38/212 ,  A61K38/215 ,  A61K38/217 ,  A61K45/06 ,  C07K16/2866 ,  C12N15/1136 ,  Y02A50/463

Abstract: The subject invention pertains to agonist peptides of type I interferons and methods of using the peptides. These peptides are based on the amino acid sequence of the C-terminus region of the type I IFN molecules and are capable of binding to the cytoplasmic domain of type I IFN receptors. Surprisingly, these peptides were found to possess the same or similar biological activity as that associated with the full-length, mature type I IFN proteins, even though these peptides do not bind to the extracellular domain of the type I IFN receptors. In one embodiment, the peptide is a peptide of IFNα. In another embodiment, the peptide is a peptide of IFNβ. Exemplified peptides of the invention include those having SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:38, SEQ ID NO:39, and SEQ ID NO:40. The subject peptides have been shown to effect increased resistance to viral infection. Peptides of the invention can be used to treat or prevent viral infections, to treat oncological disorders, and to treat autoimmune disorders, such as multiple sclerosis.

公开(公告)号：US20180106677A1

公开(公告)日：2018-04-19

申请号：US15569864

申请日：2016-04-20

Applicant: University of Florida Research Foundation, Inc.

Inventor： Charles Michael Telesco ,  William B. Sparks ,  Bo Zhao

IPC: G01J3/447 ,  G01J3/02 ,  G01J3/28

Abstract: Embodiments provide an integrated miniature polarimeter and spectrograph (IMPS) and associated methods for using an IMPS to determine Stokes parameters to describe a source beam. In one embodiment an IMPs is provided comprising a spectropolarimeter module. The spectropolarimeter module comprises a miniature optical bench; a slit component; a birefringent wedge; a dichroic prism; a spectral disperser; and a focal plane array. The slit component, birefringent wedge, dichroic prism, spectral disperser, and focal plane array are mounted to the miniature optical bench such that a beam incident on the slit component will be incident on (1) the birefringent wedge, (2) the dichroic prism, (3) the spectral disperser, and (4) the focal plane array, in that order.

公开(公告)号：US09943402B2

公开(公告)日：2018-04-17

申请号：US14821645

申请日：2015-08-07

Applicant: InSight Innovations, LLC ,  Sharklet Technologies, Inc. ,  University of Florida Research Foundation, Inc.

Inventor： Kevin H. Cuevas ,  Shravanthi T. Reddy ,  Chelsea Marie Magin ,  Michael R. Mettetal ,  Anthony B. Brennan ,  Rhea Marie May ,  Ethan Eugene Mann

IPC: A61F2/16 ,  A61F2/14 ,  A61F2/00

CPC classification number: A61F2/16 ,  A61F2/14 ,  A61F2/1601 ,  A61F2/161 ,  A61F2002/009 ,  A61L2430/16

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.